HitPredict

Interactor 1: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Interactor 2: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Hs			1 180
+	Hs
		1138904 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		RN170_HUMAN (12-133): 1.15e-26: 103: 22.48
+	Hs
		262178 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		1307272 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RNF5_HUMAN (1-164): 8.79e-56: 175: 100.00
+	Hs
		919838 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RNF5_HUMAN (1-164): 8.79e-56: 175: 100.00
+	Hs
		1292368 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		919826 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		919822 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRI11_HUMAN (14-148): 2.69e-31: 119: 17.78
+	Hs
		919712 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRI26_HUMAN (14-123): 1.73e-28: 112: 21.85
+	Hs
		1318532 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		919851 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		1336390 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		919870 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		919828 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RN170_HUMAN (12-133): 1.15e-26: 103: 22.48
+	Hs
		584923 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RO52_HUMAN (23-148): 9.12e-25: 101: 18.11
+	Hs
		1354526 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI10_HUMAN (14-156): 5.89e-24: 99: 17.45
+	Mm
		919925 UB2D2_MOUSE (4-153): 8.78e-76: 230: 34.67		TRI17_MOUSE (13-148): 1.18e-24: 100: 13.10
+	Hs
		262201 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		262167 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		919852 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TRIM7_HUMAN (1-101): 4.17e-21: 91.3: 23.48
+	Hs
		749339 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62