HitPredict

Interactor 1: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Interactor 2: APC11 (Q9NYG5)
Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)
Gene: ANAPC11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-ANAPC11
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Hs			1 84
+	Hs
		849463 UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Hs
		919882 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Hs
		921482 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Hs
		849303 UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		895979 UB2D1_MOUSE (4-153): 1.02e-75: 230: 30.00		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Hs
		919703 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		919923 UB2D2_MOUSE (4-153): 8.78e-76: 230: 34.67		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Ce
		715111 UBC2_CAEEL (4-153): 9.47e-76: 230: 32.67		RBX1_CAEEL (2-84): 2.72e-28: 99.8: 37.50
+	Hs
		895932 UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00		APC11_HUMAN (1-84): 9.39e-30: 102: 100.00
+	Hs
		895771 UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		895973 UB2D3_MOUSE (4-153): 1.55e-74: 227: 34.00		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Ce
		715108 UBC2_CAEEL (4-153): 9.47e-76: 230: 32.67		APC11_CAEEL (1-84): 1.57e-26: 95.9: 45.98
+	Sp
		804461 UBC4_SCHPO (4-152): 2.89e-74: 226: 31.54		APC11_SCHPO (1-83): 8.94e-28: 97.8: 51.19
+	Sc
		549843 UBC4_YEAST (1-152): 1.07e-73: 225: 28.95		RBX1_YEAST (2-84): 3.85e-26: 94.4: 34.09
+	Hs
		1354003 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		849472 UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		919890 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		895936 UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		296887 UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00		LTN1_HUMAN (18-80): 6.02e-13: 63.9: 23.81
+	Hs
		296893 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		LTN1_HUMAN (18-80): 6.02e-13: 63.9: 23.81