Protein: ATX2L
Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)

Gene: ATX2L, ATXN2L
Organism: Homo sapiens
Interactions: 241
UniProt ID: Q8WWM7

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005829 - cytosol
GO:0010494 - cytoplasmic stress granule
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

550378

PABP1
Polyadenylate-binding protein 1

2

15

Small-scale

0.776

High

1277871

NUFP2
FMR1-interacting protein NUFIP2

7

1

High-throughput

0.745

High

684327

DDX6
Probable ATP-dependent RNA helicase DDX6

7

10

Small-scale

0.741

High

1359585

ATX2
Ataxin-2

2

12

Small-scale

0.737

High

1359618

G3BP2
Ras GTPase-activating protein-binding protein 2

6

7

High-throughput

0.736

High

1100925

G3BP1
Ras GTPase-activating protein-binding protein 1

5

8

Small-scale

0.716

High

1187054

LSM12
Protein LSM12

4

4

High-throughput

0.694

High

1102033

PABP4
Polyadenylate-binding protein 4

1

15

High-throughput

0.691

High

1056880

FMR1
Fragile X messenger ribonucleoprotein 1

3

12

High-throughput

0.650

High

1335286

FA98A
Protein FAM98A

3

1

Small-scale

0.643

High

325951

UBR5
E3 ubiquitin-protein ligase UBR5

1

6

Small-scale

0.618

High

1359563

ATX2L
Ataxin-2-like protein

1

11

High-throughput

0.618

High

425584

ISG15
Ubiquitin-like protein ISG15

2

5

High-throughput

0.601

High

564132

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

1359589

MCRI2
MAPK regulated corepressor interacting protein 2

2

2

High-throughput

0.601

High

242420

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

1359591

ACE2
Angiotensin-converting enzyme 2

2

1

High-throughput

0.584

High

1359614

ZRAN1
Ubiquitin thioesterase ZRANB1

2

9

High-throughput

0.584

High

1359622

YTHD2
YTH domain-containing family protein 2

2

10

High-throughput

0.584

High

949670

KR124
Keratin-associated protein 12-4

2

0

High-throughput

0.580

High

765739

BMI1
Polycomb complex protein BMI-1

2

11

High-throughput

0.571

High

775224

FUS
RNA-binding protein FUS

2

20

High-throughput

0.571

High

691284

1433T
14-3-3 protein theta

1

20

High-throughput

0.554

High

730096

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.554

High

966675

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

971830

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.554

High

1049613

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

1332292

BOLL
Protein boule-like

2

14

High-throughput

0.553

High

994682

YBOX1
Y-box-binding protein 1

2

2

Small-scale

0.552

High

91772

MCRI1
Mapk-regulated corepressor-interacting protein 1

1

2

High-throughput

0.536

High

164030

NDC80
Kinetochore protein NDC80 homolog

1

2

High-throughput

0.536

High

251631

CCNT1
Cyclin-T1

1

3

High-throughput

0.536

High

833153

MNDA
Myeloid cell nuclear differentiation antigen

1

4

High-throughput

0.536

High

843811

HD
Huntingtin

1

2

High-throughput

0.536

High

867303

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

1023846

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.536

High

1113839

CUL3
Cullin-3

1

7

High-throughput

0.536

High

1115852

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.536

High

1226715

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

2

High-throughput

0.536

High

1338739

ARI1B
AT-rich interactive domain-containing protein 1B

1

15

High-throughput

0.536

High

619870

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.521

High

619227

EPOR
Erythropoietin receptor

1

1

Small-scale

0.515

High

1014562

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.515

High

927454

ATX1
Ataxin-1

1

4

High-throughput

0.508

High

821684

TPOR
Thrombopoietin receptor

1

1

Small-scale

0.504

High

185884

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

885348

HXA1
Homeobox protein Hox-A1

1

8

High-throughput

0.494

High

316623

ST17B
Serine/threonine-protein kinase 17B

1

1

High-throughput

0.489

High

329158

RCBT2
RCC1 and BTB domain-containing protein 2

1

2

High-throughput

0.489

High

659269

SP100
Nuclear autoantigen Sp-100

1

20

High-throughput

0.489

High

1123057

FHL2
Four and a half LIM domains protein 2

1

7

High-throughput

0.489

High

1135361

SLMAP
Sarcolemmal membrane-associated protein

1

3

High-throughput

0.489

High

1291806

TSYL5
Testis-specific Y-encoded-like protein 5

1

1

High-throughput

0.489

High

1359597

KTBL1
KATNB1-like protein 1

1

1

High-throughput

0.489

High

1359613

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

129285

MEN1
Menin

1

3

High-throughput

0.479

High

129779

CBX4
E3 SUMO-protein ligase CBX4

1

7

High-throughput

0.479

High

132184

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

157669

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

217494

E41L2
Band 4.1-like protein 2

1

9

High-throughput

0.479

High

223214

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

227626

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.479

High

228328

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.479

High

247398

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

5

High-throughput

0.479

High

280748

PR40A
Pre-mRNA-processing factor 40 homolog A

1

14

High-throughput

0.479

High

315816

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.479

High

346116

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

375777

RASK
GTPase KRas

1

6

High-throughput

0.479

High

396599

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

401212

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.479

High

430169

JUN
Transcription factor Jun

1

16

High-throughput

0.479

High

488524

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

2

Small-scale

0.479

High

537604

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

556249

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

565430

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

629974

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

642993

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

675601

TYY1
Transcriptional repressor protein YY1

1

8

High-throughput

0.479

High

713822

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

16

High-throughput

0.479

High

730797

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764919

CTNB1
Catenin beta-1

1

14

High-throughput

0.479

High

766723

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

799332

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.479

High

809750

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.479

High

831136

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

837749

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

862325

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

872581

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

889164

RBM25
RNA-binding protein 25

1

6

High-throughput

0.479

High

897912

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

900056

FXR1
RNA-binding protein FXR1

1

12

High-throughput

0.479

High

904970

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

927078

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

935579

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

954206

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

959221

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

970844

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

973517

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.479

High

978631

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

986126

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

990544

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1007648

CCNA1
Cyclin-A1

1

1

High-throughput

0.479

High

1022753

XIAP
E3 ubiquitin-protein ligase XIAP

1

2

Small-scale

0.479

High

1026479

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1035809

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

1045573

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1094595

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

1096126

TADBP
TAR DNA-binding protein 43

1

13

High-throughput

0.479

High

1109180

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

9

High-throughput

0.479

High

1122116

UBP2L
Ubiquitin-associated protein 2-like

1

12

High-throughput

0.479

High

1124669

SRC8
Src substrate cortactin

1

15

High-throughput

0.479

High

1127035

RBM39
RNA-binding protein 39

1

14

High-throughput

0.479

High

1129463

PUM1
Pumilio homolog 1

1

2

High-throughput

0.479

High

1137893

TNIP1
TNFAIP3-interacting protein 1

1

11

High-throughput

0.479

High

1140618

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1144425

NONO
Non-POU domain-containing octamer-binding protein

1

18

High-throughput

0.479

High

1146746

PCBP1
Poly(rC)-binding protein 1

1

9

High-throughput

0.479

High

1160221

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

19

High-throughput

0.479

High

1194241

LARP7
La-related protein 7

1

17

High-throughput

0.479

High

1205076

FA76B
Protein FAM76B

1

1

High-throughput

0.479

High

1215734

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

1217002

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

3

Small-scale

0.479

High

1221010

FBW10
F-box/WD repeat-containing protein 10

1

10

High-throughput

0.479

High

1248046

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

2

High-throughput

0.479

High

1252349

MEX3B
RNA-binding protein MEX3B

1

2

High-throughput

0.479

High

1287197

PEG10
Retrotransposon-derived protein PEG10

1

1

Small-scale

0.479

High

1289488

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1294097

DDX42
ATP-dependent RNA helicase DDX42

1

5

High-throughput

0.479

High

1310612

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

6

High-throughput

0.479

High

1313291

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1316177

DCP1B
mRNA-decapping enzyme 1B

1

12

High-throughput

0.479

High

1329059

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

11

High-throughput

0.479

High

1334697

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1346863

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1347753

FA76A
Protein FAM76A

1

1

High-throughput

0.479

High

1351914

RBCC1
RB1-inducible coiled-coil protein 1

1

11

High-throughput

0.479

High

1356383

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

3

High-throughput

0.479

High

1359564

PSPC1
Paraspeckle component 1

1

18

High-throughput

0.479

High

1359565

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1359568

REQU
Zinc finger protein ubi-d4

1

14

High-throughput

0.479

High

1359569

DAZL
Deleted in azoospermia-like

1

17

High-throughput

0.479

High

1359570

FUBP1
Far upstream element-binding protein 1

1

10

High-throughput

0.479

High

1359571

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1359572

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.479

High

1359574

SPDLY
Protein Spindly

1

1

High-throughput

0.479

High

1359576

RNF31
E3 ubiquitin-protein ligase RNF31

1

9

High-throughput

0.479

High

1359577

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.479

High

1359581

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

4

High-throughput

0.479

High

1359584

NECD
Necdin

1

3

High-throughput

0.479

High

1359587

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

1359590

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

1359592

YTHD1
YTH domain-containing family protein 1

1

10

High-throughput

0.479

High

1359593

KPCD2
Serine/threonine-protein kinase D2

1

2

High-throughput

0.479

High

1359594

UNK
RING finger protein unkempt homolog

1

5

High-throughput

0.479

High

1359596

WWTR1
WW domain-containing transcription regulator protein 1

1

15

High-throughput

0.479

High

1359598

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.479

High

1359602

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

1359604

RC3H2
Roquin-2

1

13

High-throughput

0.479

High

1359605

DCP1A
mRNA-decapping enzyme 1A

1

7

High-throughput

0.479

High

1359606

ANLN
Anillin

1

3

High-throughput

0.479

High

1359607

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

1359609

DCA13
DDB1- and CUL4-associated factor 13

1

8

High-throughput

0.479

High

1359611

DDX56
Probable ATP-dependent RNA helicase DDX56

1

9

High-throughput

0.479

High

1359615

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

5

Small-scale

0.479

High

1359617

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.479

High

1359620

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.479

High

1359621

KLH20
Kelch-like protein 20

1

3

High-throughput

0.479

High

194284

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

212290

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

542131

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

877188

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.458

High

992624

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

1096604

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

Small-scale

0.458

High

1218615

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1271754

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1359582

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

1359586

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.458

High

1359588

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.458

High

1203205

ODFP2
Outer dense fiber protein 2

1

2

High-throughput

0.445

High

1209447

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1226197

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.445

High

1234879

PKHA7
Pleckstrin homology domain-containing family A member 7

1

18

High-throughput

0.445

High

1253151

NBEL2
Neurobeachin-like protein 2

1

9

High-throughput

0.445

High

1359579

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.445

High

1359583

ZBT18
Zinc finger and BTB domain-containing protein 18

1

9

High-throughput

0.445

High

1359595

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1359603

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

1359619

DICER
Endoribonuclease Dicer

1

5

Small-scale

0.445

High

829479

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.439

High

1359567

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

128511

RN103
E3 ubiquitin-protein ligase RNF103

1

1

High-throughput

0.437

High

192506

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.437

High

248015

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

252260

CCNT2
Cyclin-T2

1

3

High-throughput

0.437

High

260218

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.437

High

318520

TOX4
TOX high mobility group box family member 4

1

20

High-throughput

0.437

High

341636

EYA4
Protein phosphatase EYA4

1

17

High-throughput

0.437

High

372691

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.437

High

406435

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.437

High

412328

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

451419

NFM
Neurofilament medium polypeptide

1

4

High-throughput

0.437

High

589265

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.437

High

606942

CEBPB
CCAAT/enhancer-binding protein beta

1

15

High-throughput

0.437

High

657642

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.437

High

696051

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

768751

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

937835

FOXA1
Hepatocyte nuclear factor 3-alpha

1

13

High-throughput

0.437

High

1004893

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1096768

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.437

High

1126139

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

1156796

E2F4
Transcription factor E2F4

1

3

High-throughput

0.437

High

1241276

TAF2
Transcription initiation factor TFIID subunit 2

1

1

High-throughput

0.437

High

1250020

WDR82
WD repeat-containing protein 82

1

9

High-throughput

0.437

High

1254826

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1258890

H32
Histone H3.2

1

18

Small-scale

0.437

High

1276549

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.437

High

1324023

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.437

High

1329770

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.437

High

1352656

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

1359566

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1359573

ZBT10
Zinc finger and BTB domain-containing protein 10

1

15

Small-scale

0.437

High

1359599

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

1359601

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.437

High

1359608

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.437

High

1359610

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

1359612

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

1359616

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

213208

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

1066725

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

1198611

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

939217

SUMO3
Small ubiquitin-related modifier 3

1

5

Small-scale

0.407

High

887053

CEBPA
CCAAT/enhancer-binding protein alpha

1

18

High-throughput

0.373

High

325007

HEXI1
Protein HEXIM1

2

0

High-throughput

0.318

High

1294905

KMT5C
Histone-lysine N-methyltransferase KMT5C

1

0

High-throughput

0.279

Low

1359575

TCAL4
Transcription elongation factor A protein-like 4

1

0

High-throughput

0.279

Low

1359578

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.279

Low

1135752

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1359600

AAMDC
Mth938 domain-containing protein

1

0

High-throughput

0.249

Low

1311010

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.232

Low

1359580

PTHD1
Patched domain-containing protein 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025