HitPredict

Interactor 1: NFAC2 (Q60591)
Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)
Gene: Nfatc2

Interactor 2: FOXP3 (Q99JB6)
Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]
Gene: FOXP3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 22922362, 17377532
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Forkhead~RHD_DNA_bind
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
and 12 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 927
Mm

1 429
+ Hs
+ Hs
+ Mm
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+ Hs
+ Hs
+ Hs
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+ Dm
+ Dm
+ Dm
+ Dm
+ Hs

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Last updated: 15 Jul 2024