Protein: LRCH3
DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)

Gene: LRCH3
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q96II8

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0032185 - septin cytoskeleton organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1394210

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

4

18

High-throughput

0.900

High

1115908

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

3

5

High-throughput

0.861

High

1218306

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

3

20

High-throughput

0.779

High

1338510

DOCK8
Dedicator of cytokinesis protein 8

7

12

High-throughput

0.749

High

1393340

DOCK6
Dedicator of cytokinesis protein 6

6

12

High-throughput

0.730

High

281537

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

2

19

High-throughput

0.726

High

1394197

PIHD1
PIH1 domain-containing protein 1

5

1

High-throughput

0.717

High

1394212

SGT1
Protein SGT1 homolog

4

20

High-throughput

0.697

High

996518

ACTS
Actin, alpha skeletal muscle

1

5

High-throughput

0.691

High

1148252

RSU1
Ras suppressor protein 1

1

19

High-throughput

0.691

High

1161601

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.691

High

1332983

MLKL
Mixed lineage kinase domain-like protein

1

20

High-throughput

0.691

High

1394203

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.691

High

1394185

DOCK7
Dedicator of cytokinesis protein 7

8

12

High-throughput

0.687

High

1394209

MYO6
Unconventional myosin-VI

3

10

High-throughput

0.680

High

1394184

VCIP1
Deubiquitinating protein VCPIP1

3

0

High-throughput

0.634

High

170284

AURKA
Aurora kinase A

1

4

High-throughput

0.618

High

862692

UTRN
Utrophin

1

7

High-throughput

0.618

High

901485

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.618

High

955475

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.618

High

988609

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.618

High

1394183

LRCH3
DISP complex protein LRCH3

1

19

High-throughput

0.618

High

1394192

MOB1A
MOB kinase activator 1A

2

5

High-throughput

0.611

High

1293327

DAA11
Dynein axonemal assembly factor 11

2

19

High-throughput

0.606

High

1273122

MOB1B
MOB kinase activator 1B

2

5

High-throughput

0.584

High

410999

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

516365

CALM1
Calmodulin-1

1

19

High-throughput

0.575

High

516443

CALM2
Calmodulin-2

1

19

High-throughput

0.575

High

516571

CALM3
Calmodulin-3

1

19

High-throughput

0.575

High

1394199

TMOD3
Tropomodulin-3

2

4

High-throughput

0.574

High

177400

ARHGB
Rho guanine nucleotide exchange factor 11

2

1

High-throughput

0.571

High

396713

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

992519

RS21
Small ribosomal subunit protein eS21

2

0

High-throughput

0.559

High

412439

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

710426

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.553

High

277393

TP4A3
Protein tyrosine phosphatase type IVA 3

1

1

High-throughput

0.536

High

277948

SH3L1
Adapter SH3BGRL

1

1

High-throughput

0.536

High

530224

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.536

High

570957

MIF
Macrophage migration inhibitory factor

1

2

High-throughput

0.536

High

682575

S100P
Protein S100-P

1

5

High-throughput

0.536

High

773598

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

866784

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

964709

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.536

High

966741

1433G
14-3-3 protein gamma

1

13

High-throughput

0.536

High

1052086

CALD1
Caldesmon

1

10

High-throughput

0.536

High

1109987

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.536

High

1154286

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

1

High-throughput

0.536

High

1160724

DREB
Drebrin

1

1

High-throughput

0.536

High

1307699

CRLF3
Cytokine receptor-like factor 3

1

1

High-throughput

0.536

High

1394190

PAR6B
Partitioning defective 6 homolog beta

1

1

High-throughput

0.536

High

1394191

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.536

High

1394193

PAR6A
Partitioning defective 6 homolog alpha

1

7

High-throughput

0.536

High

1394200

SEP10
Septin-10

2

6

High-throughput

0.533

High

158666

TYB4Y
Thymosin beta-4, Y-chromosomal

1

0

High-throughput

0.513

High

482952

TPM1
Tropomyosin alpha-1 chain

1

0

High-throughput

0.513

High

983935

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.513

High

1010351

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.513

High

1234610

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

1394198

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.513

High

1394208

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1394206

ANR50
Ankyrin repeat domain-containing protein 50

1

3

High-throughput

0.489

High

1394207

COR1C
Coronin-1C

1

2

High-throughput

0.489

High

177289

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

3

High-throughput

0.479

High

331239

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

831246

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

1045643

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1091444

ANK3
Ankyrin-3

1

4

High-throughput

0.479

High

1104864

SNTB2
Beta-2-syntrophin

1

8

High-throughput

0.479

High

1106659

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.479

High

1118125

DX39B
Spliceosome RNA helicase DDX39B

1

3

Small-scale

0.479

High

1118444

SNTB1
Beta-1-syntrophin

1

9

High-throughput

0.479

High

1137941

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.479

High

1140696

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1156405

SEPT7
Septin-7

1

7

High-throughput

0.479

High

1197540

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.479

High

1227258

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

1325511

FBXW8
F-box/WD repeat-containing protein 8

1

8

High-throughput

0.479

High

1380085

FBXW7
F-box/WD repeat-containing protein 7

1

7

High-throughput

0.479

High

1385602

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1394194

ANLN
Anillin

1

3

High-throughput

0.479

High

1394196

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.479

High

1394201

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.479

High

1394202

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1394204

SEPT9
Septin-9

1

7

High-throughput

0.479

High

1394205

XPO7
Exportin-7

1

5

High-throughput

0.479

High

1394213

TRI17
E3 ubiquitin-protein ligase TRIM17

1

2

Small-scale

0.479

High

1156817

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1294165

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.458

High

765799

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

1394186

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

76565

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

19

High-throughput

0.437

High

279460

TULP3
Tubby-related protein 3

1

3

High-throughput

0.437

High

372850

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

1329811

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.437

High

1333069

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

3

High-throughput

0.437

High

1365283

SEPT8
Septin-8

1

7

High-throughput

0.437

High

1367020

ESR2
Estrogen receptor beta

1

12

High-throughput

0.437

High

1394189

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

High-throughput

0.437

High

1394195

SEP11
Septin-11

1

7

High-throughput

0.437

High

1394211

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.437

High

1103316

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

1394188

DGC6L
Protein DGCR6L

2

0

High-throughput

0.316

High

169204

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

317081

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

0

High-throughput

0.279

Low

328720

VAMP5
Vesicle-associated membrane protein 5

1

0

High-throughput

0.279

Low

354030

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

515897

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

853373

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.279

Low

1009622

CXCL6
C-X-C motif chemokine 6

1

0

High-throughput

0.279

Low

1092807

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1093767

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1120489

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1388080

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1394187

H2A1J
Histone H2A type 1-J

1

0

High-throughput

0.249

Low

389870

TTHY
Transthyretin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025