HitPredict

Interactor 1: TRAF3 (Q60803)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Interactor 2: TCAM1 (Q80UF7)
TIR domain-containing adapter molecule 1 (TICAM-1) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (TIR domain-containing adapter protein inducing IFN-beta)
Gene: Ticam1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 0.60 0.686

The method score is based on:

Property Details
Experiments 19898473, 16306937, 16306936, 17327220
Identification Methods pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005739 - mitochondrion
GO:0010008 - endosome membrane
GO:0019901 - protein kinase binding
GO:0032481 - positive regulation of type I interferon production
GO:0034142 - toll-like receptor 4 signaling pathway
and 1 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 567
Mm

1 732
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024