HitPredict

Interactor 1: DVL2 (Q60838)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: CRK (Q64010)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19920076
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0019904 - protein domain specific binding GO:0030674 - protein-macromolecule adaptor activity GO:0046330 - positive regulation of JNK cascade
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 736 Mm			1 304
+	Mm
		1141502 DVL2_MOUSE (13-736): 0: 541: 100.00		PLCG2_MOUSE (11-301): 4.81e-29: 119: 15.43
+	Mm
		1141128 DVL2_MOUSE (13-736): 0: 541: 100.00		GRB2_MOUSE (135-297): 2.89e-26: 104: 15.67
+	Hs
		150940 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		GRB2_HUMAN (135-297): 3.88e-26: 104: 15.67
+	Hs
		151122 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		SH3K1_HUMAN (114-193): 4.42e-11: 65.2: 21.95
+	Hs
		151007 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		ITSN1_HUMAN (207-302): 2.54e-10: 63.3: 14.56
+	Hs
		150792 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		GRAP2_HUMAN (18-192): 1.77e-10: 62.9: 17.17
+	Hs
		150653 DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40		NCK2_HUMAN (2-117): 8.52e-14: 73.2: 22.22
+	Hs
		876420 AFAD_HUMAN (261-701): 1.31e-43: 172: 19.40		DNMBP_HUMAN (119-293): 1.45e-46: 169: 28.80
+	Hs
		924673 RIMS1_HUMAN (85-722): 4.93e-50: 192: 13.83		GRB2_HUMAN (135-297): 3.88e-26: 104: 15.67
+	Hs
		876349 AFAD_HUMAN (261-701): 1.31e-43: 172: 19.40		GRB2_HUMAN (135-297): 3.88e-26: 104: 15.67
+	Hs
		924957 RIMS2_HUMAN (75-720): 1.7e-40: 162: 12.58		GRB2_HUMAN (135-297): 3.88e-26: 104: 15.67
+	Hs
		557729 RIMS1_HUMAN (85-722): 4.93e-50: 192: 13.83		NCK1_HUMAN (2-99): 2.87e-13: 71.4: 18.18
+	Hs
		209100 Q86TH3_HUMAN (473-736): 2.9e-51: 186: 48.34		NCK2_HUMAN (2-117): 8.52e-14: 73.2: 22.22
+	Hs
		209019 AFAD_HUMAN (261-701): 1.31e-43: 172: 19.40		NCK2_HUMAN (2-117): 8.52e-14: 73.2: 22.22
+	Hs
		557832 RIMS2_HUMAN (75-720): 1.7e-40: 162: 12.58		NCK1_HUMAN (2-99): 2.87e-13: 71.4: 18.18
+	Mm
		1141133 DLG4_MOUSE (199-494): 3.53e-22: 103: 15.82		GRB2_MOUSE (135-297): 2.89e-26: 104: 15.67
+	Hs
		924466 DLG4_HUMAN (199-494): 4.13e-22: 103: 15.82		GRB2_HUMAN (135-297): 3.88e-26: 104: 15.67
+	Mm
		223014 DLG4_MOUSE (199-494): 3.53e-22: 103: 15.82		NCK2_MOUSE (2-117): 1.29e-15: 78.4: 24.79
+	Mm
		1143451 DLG4_MOUSE (199-494): 3.53e-22: 103: 15.82		SH3K1_MOUSE (114-193): 1.23e-11: 67.1: 20.73