Protein: AFG3
Mitochondrial inner membrane m-AAA protease component YTA10 (EC 3.4.24.-) (EC 3.6.-.-) (ATPase family gene 3 protein) (Tat-binding homolog 10)

Gene: AFG3
Organism: Saccharomyces cerevisiae S288C
Interactions: 61
UniProt ID: P39925

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

814941

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

9

14

Small-scale

0.965

High

814944

PHB1
Prohibitin-1

5

10

Small-scale

0.915

High

814947

PHB2
Prohibitin-2

3

10

Small-scale

0.847

High

745127

YME1
Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1

1

15

Small-scale

0.618

High

752286

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.618

High

579433

HSC82
ATP-dependent molecular chaperone HSC82

2

6

High-throughput

0.594

High

814946

TOM22
Mitochondrial import receptor subunit TOM22

2

2

High-throughput

0.584

High

672541

RM32
Large ribosomal subunit protein bL32m

2

0

Small-scale

0.576

High

510515

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.571

High

806280

KOG1
Target of rapamycin complex 1 subunit KOG1

1

0

High-throughput

0.529

High

484763

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

416546

HXKB
Hexokinase-2

1

2

High-throughput

0.500

High

544956

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.500

High

592272

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.500

High

597147

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.500

High

607763

HXKG
Glucokinase-1

1

2

High-throughput

0.500

High

626750

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

740664

CBS
Cystathionine beta-synthase

1

2

High-throughput

0.500

High

814955

GET3
ATPase GET3

1

0

High-throughput

0.486

High

432330

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

555082

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

357772

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

1

High-throughput

0.479

High

357831

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

1

High-throughput

0.479

High

360659

COX2
Cytochrome c oxidase subunit 2

1

2

High-throughput

0.479

High

360790

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.479

High

360883

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

1

High-throughput

0.479

High

382909

RMAR
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.479

High

399838

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

417102

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.479

High

432006

ATPF
ATP synthase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

453155

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

5

High-throughput

0.479

High

453279

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

5

High-throughput

0.479

High

465334

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.479

High

470685

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

1

1

High-throughput

0.479

High

661794

TOM40
Mitochondrial import receptor subunit TOM40

1

2

High-throughput

0.479

High

677074

MGR1
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1

1

1

Small-scale

0.479

High

746576

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.479

High

746842

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

2

High-throughput

0.479

High

781381

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

814940

OXA1
Mitochondrial inner membrane protein OXA1

1

3

High-throughput

0.479

High

814942

PUP1
PUP1 protein homolog

1

1

High-throughput

0.479

High

814948

MCY1
Putative mitochondrial cysteine synthase

1

2

High-throughput

0.479

High

814949

RCF2
Respiratory supercomplex factor 2, mitochondrial

1

1

High-throughput

0.479

High

814951

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

814952

MGR3
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3

1

1

Small-scale

0.479

High

814953

ATG33
Autophagy-related protein 33

1

1

High-throughput

0.479

High

482197

ATPO
ATP synthase subunit 5, mitochondrial

1

0

High-throughput

0.458

High

745235

COX13
Cytochrome c oxidase subunit 13, mitochondrial

1

0

High-throughput

0.458

High

392769

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.445

High

814943

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.445

High

814945

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

814950

JJJ1
J protein JJJ1

1

6

High-throughput

0.445

High

794996

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

554427

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.407

High

814954

UTP4
U3 small nucleolar RNA-associated protein 4

1

1

High-throughput

0.407

High

798221

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.279

Low

408577

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

439345

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.261

Low

746278

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.261

Low

747866

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

653862

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025