HitPredict

Interactor 1: ACVL1 (Q61288)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: Acvrl1

Interactor 2: RHOH (Q9D3G9)
Rho-related GTP-binding protein RhoH
Gene: RHOH

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24319055
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 502 Mm			1 191
+	Hs
		436181 BMR1A_HUMAN (22-496): 5.83e-135: 402: 43.66		RHOC_HUMAN (6-180): 1.96e-84: 249: 40.66
+	Hs
		738323 BMR1A_HUMAN (22-496): 5.83e-135: 402: 43.66		RHOB_HUMAN (6-191): 1.53e-84: 249: 40.42
+	Mm
		983316 ACVL1_MOUSE (1-502): 1.74e-147: 433: 100.00		RAC2_MOUSE (2-191): 4.2e-72: 218: 38.58
+	Hs
		436183 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		RHOC_HUMAN (6-180): 1.96e-84: 249: 40.66
+	Hs
		738519 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		RHOB_HUMAN (6-191): 1.53e-84: 249: 40.42
+	Hs
		738320 BMR1A_HUMAN (22-496): 5.83e-135: 402: 43.66		RAC3_HUMAN (2-171): 5.46e-72: 217: 42.37
+	Hs
		738322 BMR1A_HUMAN (22-496): 5.83e-135: 402: 43.66		RHOA_HUMAN (6-191): 4.22e-71: 215: 37.31
+	Hs
		738321 BMR1A_HUMAN (22-496): 5.83e-135: 402: 43.66		CDC42_HUMAN (2-191): 6.53e-71: 214: 40.10
+	Hs
		436182 ACV1B_HUMAN (12-496): 5.18e-121: 365: 45.84		RHOC_HUMAN (6-180): 1.96e-84: 249: 40.66
+	Hs
		738438 ACV1B_HUMAN (12-496): 5.18e-121: 365: 45.84		RHOB_HUMAN (6-191): 1.53e-84: 249: 40.42
+	Hs
		738521 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		RAC1_HUMAN (2-191): 6.42e-75: 224: 38.58
+	Hs
		564434 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		RHOQ_HUMAN (5-190): 2.01e-72: 219: 38.46
+	Hs
		738527 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		RHOG_HUMAN (2-191): 1.66e-72: 218: 37.56
+	Hs
		738515 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		RAC3_HUMAN (2-171): 5.46e-72: 217: 42.37
+	Hs
		738517 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		RHOA_HUMAN (6-191): 4.22e-71: 215: 37.31
+	Hs
		738516 TGFR1_HUMAN (32-494): 7.26e-131: 390: 48.31		CDC42_HUMAN (2-191): 6.53e-71: 214: 40.10
+	Hs
		436293 BMPR2_HUMAN (40-501): 1.45e-100: 326: 29.30		RHOC_HUMAN (6-180): 1.96e-84: 249: 40.66
+	Hs
		739935 TGFR2_HUMAN (79-493): 2.29e-114: 350: 32.15		CDC42_HUMAN (2-191): 6.53e-71: 214: 40.10
+	Mm
		983317 TGFR2_MOUSE (79-498): 4.97e-112: 344: 32.55		RAC2_MOUSE (2-191): 4.2e-72: 218: 38.58
+	Hs
		564416 AVR2A_HUMAN (35-493): 6.96e-112: 342: 29.09		RHOQ_HUMAN (5-190): 2.01e-72: 219: 38.46