Interactor 1: M3K7 (Q62073)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: Map3k7
Interactor 2: BIRC2 (Q62210)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (Inhibitor of apoptosis protein 2) (mIAP2) (RING-type E3 ubiquitin transferase BIRC2)
Gene: BIRC2
Species: Mus musculus
Source: innatedb
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.44 | 1.00 | 0.665 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 19898473 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | BIR~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0060546 - negative regulation of necroptotic process GO:0071356 - cellular response to tumor necrosis factor GO:1902443 - negative regulation of ripoptosome assembly involved in necroptotic process GO:2000377 - regulation of reactive oxygen species metabolic process |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
