Protein: SPTB1
Spectrin beta chain, erythrocytic (Beta-I spectrin)

Gene: SPTB1, SPTB
Organism: Homo sapiens
Interactions: 79
UniProt ID: P11277

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0008091 - spectrin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

386429

SPTA1
Spectrin alpha chain, erythrocytic 1

5

20

Small-scale

0.920

High

540251

SPTN1
Spectrin alpha chain, non-erythrocytic 1

3

19

Small-scale

0.840

High

540247

CABP4
Calcium-binding protein 4

1

6

High-throughput

0.691

High

126448

RHOD
Rho-related GTP-binding protein RhoD

3

20

High-throughput

0.667

High

501771

RB40L
Ras-related protein Rab-40A-like

3

10

High-throughput

0.667

High

540233

NCAM1
Neural cell adhesion molecule 1

1

15

Small-scale

0.647

High

540235

ANK1
Ankyrin-1

1

19

Small-scale

0.647

High

540239

ADDA
Alpha-adducin

1

9

Small-scale

0.647

High

540248

ACTB
Actin, cytoplasmic 1

1

20

Small-scale

0.647

High

540231

SPTB1
Spectrin beta chain, erythrocytic

1

18

High-throughput

0.618

High

540258

CPLX4
Complexin-4

2

0

High-throughput

0.602

High

540266

RM38
Large ribosomal subunit protein mL38

2

0

High-throughput

0.602

High

540242

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

6

High-throughput

0.594

High

540278

SH22A
SH2 domain-containing protein 2A

2

20

High-throughput

0.594

High

540280

PDLI7
PDZ and LIM domain protein 7

1

20

High-throughput

0.575

High

540286

ZBT12
Zinc finger and BTB domain-containing protein 12

2

9

High-throughput

0.558

High

540263

TXND5
Thioredoxin domain-containing protein 5

2

1

High-throughput

0.558

High

279269

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

333288

SNAPN
SNARE-associated protein Snapin

1

5

High-throughput

0.541

High

540234

ENOB
Beta-enolase

1

1

High-throughput

0.541

High

540244

NRIP1
Nuclear receptor-interacting protein 1

1

3

High-throughput

0.541

High

540245

SPB4
Serpin B4

1

1

High-throughput

0.536

High

540276

CSTN2
Calsyntenin-2

1

13

High-throughput

0.536

High

540240

BASI
Basigin

1

12

High-throughput

0.515

High

540257

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.515

High

421391

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

335420

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

352746

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.513

High

540241

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.513

High

540253

ACOT6
Acyl-coenzyme A thioesterase 6

1

0

High-throughput

0.513

High

540271

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.513

High

540285

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

538857

EPB41
Protein 4.1

1

20

Small-scale

0.501

High

540237

1433T
14-3-3 protein theta

1

20

High-throughput

0.501

High

540249

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.493

High

540264

O13C5
Olfactory receptor 13C5

1

0

High-throughput

0.493

High

540246

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.489

High

540254

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

8

High-throughput

0.489

High

540260

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

14

High-throughput

0.489

High

540268

RN145
RING finger protein 145

1

3

High-throughput

0.489

High

540270

DIDO1
Death-inducer obliterator 1

1

10

High-throughput

0.489

High

540288

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.489

High

156889

CTRO
Citron Rho-interacting kinase

1

18

High-throughput

0.479

High

188797

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.479

High

189393

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

222668

PRC1
Protein regulator of cytokinesis 1

1

19

High-throughput

0.479

High

488709

FURIN
Furin

1

3

High-throughput

0.479

High

540232

IFM1
Interferon-induced transmembrane protein 1

1

7

High-throughput

0.479

High

540236

BTF3
Transcription factor BTF3

1

5

High-throughput

0.479

High

540243

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.479

High

540250

KPCD
Protein kinase C delta type

1

5

High-throughput

0.479

High

540252

KIF14
Kinesin-like protein KIF14

1

12

High-throughput

0.479

High

540265

CHM4C
Charged multivesicular body protein 4c

1

18

High-throughput

0.479

High

540272

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

540274

GAN
Gigaxonin

1

6

High-throughput

0.479

High

540275

CHM4B
Charged multivesicular body protein 4b

1

18

High-throughput

0.479

High

540277

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

540279

ANLN
Anillin

1

11

High-throughput

0.479

High

540282

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.479

High

540284

CLC4E
C-type lectin domain family 4 member E

1

9

High-throughput

0.479

High

105204

APRIO
Alternative prion protein

1

9

High-throughput

0.437

High

290434

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.437

High

330611

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

352305

TOP3B
DNA topoisomerase 3-beta-1

1

4

High-throughput

0.437

High

472265

CFAH
Complement factor H

1

4

Small-scale

0.437

High

540281

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

5

High-throughput

0.437

High

388488

CRP

2

0

High-throughput

0.328

High

540259

GLBL2
Beta-galactosidase-1-like protein 2

2

0

High-throughput

0.328

High

540269

NMNA3
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

2

0

High-throughput

0.328

High

540238

IL13
Interleukin-13

1

0

High-throughput

0.279

Low

540261

MTURN
Maturin

1

0

High-throughput

0.279

Low

540267

C2AIL
CDKN2AIP N-terminal-like protein

1

0

High-throughput

0.279

Low

540283

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

540287

BOLA1
BolA-like protein 1

1

0

High-throughput

0.279

Low

540255

MTFR2
Mitochondrial fission regulator 2

1

0

High-throughput

0.269

Low

540262

CJ053
UPF0728 protein C10orf53

1

0

High-throughput

0.269

Low

540256

CP20A
Cytochrome P450 20A1

1

0

High-throughput

0.249

Low

540273

CFA74
Cilia- and flagella-associated protein 74

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025