HitPredict

Interactor 1: KPCI (Q62074)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: Prkci

Interactor 2: PAR6A (Q9Z101)
Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A)
Gene: Pard6a

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	1.00	0.653

Property	Details
Experiments	12813044
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PB1~PB1, PB1~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005923 - bicellular tight junction GO:0016324 - apical plasma membrane GO:0045197 - establishment or maintenance of epithelial cell apical/basal polarity and 1 others more... GO:0120157 - PAR polarity complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Mm			1 346
+	Hs
		784096 KPCI_HUMAN (1-595): 0: 685: 98.32		PAR6A_HUMAN (1-346): 5.37e-103: 308: 93.06
+	Mm
		1143287 KPCI_MOUSE (1-595): 0: 696: 100.00		PAR6B_MOUSE (1-336): 2.72e-86: 266: 50.30
+	Hs
		784081 KPCI_HUMAN (1-595): 0: 685: 98.32		PAR6B_HUMAN (1-336): 1.23e-88: 272: 50.45
+	Hs
		784080 KPCI_HUMAN (1-595): 0: 685: 98.32		PAR6G_HUMAN (12-333): 1.77e-84: 262: 52.23
+	Mm
		973821 KPCZ_MOUSE (1-595): 0: 613: 70.03		PAR6A_MOUSE (1-346): 3.9e-109: 323: 100.00
+	Hs
		983925 KPCZ_HUMAN (1-595): 0: 613: 69.70		PAR6A_HUMAN (1-346): 5.37e-103: 308: 93.06
+	Hs
		159170 KPCI_HUMAN (1-595): 0: 685: 98.32		CSKP_HUMAN (23-345): 7.23e-64: 219: 19.10
+	Hs
		983913 KPCZ_HUMAN (1-595): 0: 613: 69.70		PAR6B_HUMAN (1-336): 1.23e-88: 272: 50.45
+	Hs
		983912 KPCZ_HUMAN (1-595): 0: 613: 69.70		PAR6G_HUMAN (12-333): 1.77e-84: 262: 52.23
+	Dm
		54638 APKC_DROME (1-595): 0: 630: 66.17		O97111_DROME (9-286): 2.91e-71: 227: 52.27
+	Ce
		1090588 KPC3_CAEEL (10-595): 0: 578: 55.98		PAR6_CAEEL (14-268): 8.22e-71: 224: 55.64
+	Dm
		54630 APKC_DROME (1-595): 0: 630: 66.17		M9PJD0_DROME (133-291): 1.8e-35: 139: 29.59
+	Hs
		1020167 PKN2_HUMAN (2-585): 2.14e-164: 496: 28.64		PTN13_HUMAN (134-337): 4.38e-13: 72.7: 14.08
+	Mm
		554913 KPCE_MOUSE (30-190): 1.69e-26: 116: 20.57		DLG4_MOUSE (122-252): 1.7e-21: 97.4: 20.61
+	Mm
		934625 KPCB_MOUSE (111-191): 2.1e-16: 84.6: 30.86		DLG4_MOUSE (122-252): 1.7e-21: 97.4: 20.61
+	Rn
		404387 KPCA_RAT (111-191): 7.93e-16: 83: 30.86		DLG4_RAT (122-252): 1.66e-21: 97.8: 20.61
+	Hs
		566353 KPCA_HUMAN (111-191): 8.22e-16: 83: 30.86		DLG4_HUMAN (122-252): 1.72e-21: 97.4: 20.61
+	Rn
		404390 KPCA_RAT (111-191): 7.93e-16: 83: 30.86		DLG3_RAT (121-239): 5.3e-17: 84.3: 22.69
+	Hs
		566388 KPCA_HUMAN (111-191): 8.22e-16: 83: 30.86		SCRIB_HUMAN (103-246): 8.32e-12: 68.5: 24.66
+	Mm
		934628 KPCB_MOUSE (111-191): 2.1e-16: 84.6: 30.86		INADL_MOUSE (148-334): 6.86e-11: 65.8: 13.37