Protein: SYDE2
Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2)

Gene: SYDE2
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q5VT97

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0016477 - cell migration
GO:0046578 - regulation of Ras protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

958291

ARP2
Actin-related protein 2

1

16

High-throughput

0.691

High

729925

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

966446

1433G
14-3-3 protein gamma

4

20

High-throughput

0.683

High

691105

1433T
14-3-3 protein theta

3

20

High-throughput

0.650

High

990332

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

1049397

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

988433

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

971624

1433E
14-3-3 protein epsilon

2

12

High-throughput

0.611

High

1217691

APBB2
Amyloid beta precursor protein binding family B member 2

3

3

High-throughput

0.609

High

407639

S100B
Protein S100-B

2

10

High-throughput

0.601

High

51085

PKHG3
Pleckstrin homology domain-containing family G member 3

2

6

High-throughput

0.571

High

127104

APBB1
Amyloid beta precursor protein binding family B member 1

2

3

High-throughput

0.571

High

171255

MYPT1
Protein phosphatase 1 regulatory subunit 12A

2

11

High-throughput

0.571

High

442355

GELS
Gelsolin

2

2

High-throughput

0.571

High

447779

TPM3
Tropomyosin alpha-3 chain

2

1

High-throughput

0.571

High

717850

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

8

High-throughput

0.571

High

720490

AMRP
Alpha-2-macroglobulin receptor-associated protein

2

1

High-throughput

0.571

High

910936

IMA1
Importin subunit alpha-1

2

4

High-throughput

0.571

High

1143152

PLEC
Plectin

2

5

High-throughput

0.571

High

1217687

FIP1
Pre-mRNA 3'-end-processing factor FIP1

2

3

High-throughput

0.571

High

1217688

MPRIP
Myosin phosphatase Rho-interacting protein

2

13

High-throughput

0.571

High

1217692

NEB2
Neurabin-2

2

20

High-throughput

0.571

High

228280

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

2

3

High-throughput

0.521

High

685605

U2AF2
Splicing factor U2AF 65 kDa subunit

2

4

High-throughput

0.521

High

722985

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

1

High-throughput

0.521

High

939196

SUMO3
Small ubiquitin-related modifier 3

2

2

High-throughput

0.521

High

1217695

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

20

High-throughput

0.521

High

450999

LDHB
L-lactate dehydrogenase B chain

1

4

High-throughput

0.479

High

461586

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.479

High

468482

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

660095

COF1
Cofilin-1

1

1

High-throughput

0.479

High

877142

KC1D
Casein kinase I isoform delta

1

14

High-throughput

0.479

High

1036746

DSG1
Desmoglein-1

1

11

High-throughput

0.479

High

1052037

CALD1
Caldesmon

1

16

High-throughput

0.479

High

1217686

RN123
E3 ubiquitin-protein ligase RNF123

1

10

High-throughput

0.479

High

979805

H4
Histone H4

1

2

High-throughput

0.470

High

1145586

RCN1
Reticulocalbin-1

1

6

High-throughput

0.470

High

522439

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.437

High

1015042

ARF5
ADP-ribosylation factor 5

1

9

High-throughput

0.437

High

1217693

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.437

High

1217696

XPO7
Exportin-7

1

17

High-throughput

0.437

High

1217697

ATIF1
ATPase inhibitor, mitochondrial

1

2

High-throughput

0.437

High

1217689

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

9

High-throughput

0.407

High

1217690

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

3

High-throughput

0.407

High

1217694

K1671
Uncharacterized protein KIAA1671

2

0

High-throughput

0.298

High

1217698

PLAK2
PALM2-AKAP2 fusion protein

2

0

High-throughput

0.298

High

1015234

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025