HitPredict

Interactor 1: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: MAGI3 (Q9EQJ9)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)
Gene: MAGI3

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36604605
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, PDZ~PDZ, Guanylate_kin~SH3_1
Common GO terms	GO:0005109 - frizzled binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0019903 - protein phosphatase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 724 Mm			1 1476
+	Rn
		677805 DLG4_RAT (1-724): 0: 671: 99.45		NHRF3_RAT (36-544): 8.45e-26: 115: 11.15
+	Mm
		1143387 DLG4_MOUSE (1-724): 0: 671: 100.00		DLG1_MOUSE (13-608): 1.06e-24: 114: 8.85
+	Hs
		942349 DLG4_HUMAN (1-724): 0: 671: 99.59		DLG2_HUMAN (2-136): 8.61e-21: 101: 15.56
+	Mm
		1143467 DLG4_MOUSE (1-724): 0: 671: 100.00		DLG2_MOUSE (2-136): 2.14e-20: 100: 15.56
+	Mm
		936180 DLG4_MOUSE (1-724): 0: 671: 100.00		DLG3_MOUSE (14-420): 2.44e-20: 99.8: 10.19
+	Hs
		942321 DLG4_HUMAN (1-724): 0: 671: 99.59		DLG4_HUMAN (105-503): 2.28e-20: 99.8: 12.16
+	Mm
		1143321 DLG4_MOUSE (1-724): 0: 671: 100.00		DLG4_MOUSE (105-503): 2.64e-20: 99.5: 11.91
+	Rn
		677790 DLG4_RAT (1-724): 0: 671: 99.45		DLG3_RAT (14-420): 3.32e-20: 99.5: 10.19
+	Mm
		1113136 DLG4_MOUSE (1-724): 0: 671: 100.00		Q3UP61_MOUSE (16-125): 2.73e-13: 77.1: 13.64
+	Rn
		677787 DLG4_RAT (1-724): 0: 671: 99.45		DLG1_RAT (918-1118): 8.28e-12: 72.1: 17.37
+	Hs
		942364 DLG4_HUMAN (1-724): 0: 671: 99.59		DLG3_HUMAN (946-1382): 2.55e-11: 70.6: 12.83
+	Mm
		1119795 DLG4_MOUSE (1-724): 0: 671: 100.00		Q52KF7_MOUSE (946-1382): 5.58e-11: 69.4: 12.83
+	Hs
		1021542 DLG3_HUMAN (28-724): 0: 600: 64.92		DLG1_HUMAN (13-608): 3.4e-25: 116: 9.02
+	Hs
		1077285 DLG3_HUMAN (28-724): 0: 600: 64.92		DLG2_HUMAN (2-136): 8.61e-21: 101: 15.56
+	Mm
		936188 DLG3_MOUSE (20-724): 0: 585: 63.94		DLG2_MOUSE (2-136): 2.14e-20: 100: 15.56
+	Rn
		1144010 DLG3_RAT (20-724): 0: 585: 63.94		DLG1_RAT (918-1118): 8.28e-12: 72.1: 17.37