HitPredict

Interactor 1: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Interactor 2: NEDD8 (Q71UE8)
NEDD8 (Neddylin) (Ubiquitin-like protein NEDD8)
Gene: NEDD8

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22871113
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0019941 - modification-dependent protein catabolic process GO:0031386 - protein tag activity GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 810 Rn			1 81
+	Rn
		924232 UBC_RAT (1-810): 0: 1000: 100.00		RS27A_RAT (1-77): 2.48e-38: 126: 57.14
+	Hs
		475590 UBC_HUMAN (1-533): 0: 662: 99.81		RS27A_HUMAN (1-77): 1.85e-38: 126: 57.14
+	Hs
		475591 UBC_HUMAN (1-533): 0: 662: 99.81		RL40_HUMAN (1-76): 3.05e-35: 117: 57.90
+	Hs
		475818 UBC_HUMAN (1-533): 0: 662: 99.81		NEDD8_HUMAN (1-81): 1.15e-31: 107: 98.77
+	Dm
		574862 Q9W418_DROME (305-801): 0: 604: 96.18		RL40_DROME (1-76): 1.43e-35: 118: 57.90
+	At
		96040 UBQ10_ARATH (381-801): 9.04e-177: 517: 91.69		F4I9X6_ARATH (1-77): 1.64e-23: 92.1: 43.96
+	Pf
		1181539 Q7KQK2_PLAF7 (457-801): 3.24e-137: 413: 93.04		Q7KQK2_PLAF7 (1-76): 1.9e-30: 111: 59.21
+	Sc
		408224 UBI4P_YEAST (457-801): 3.68e-132: 400: 90.73		RS31_YEAST (1-70): 1.26e-31: 109: 52.86
+	Hs
		923944 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		RS27A_HUMAN (1-77): 1.85e-38: 126: 57.14
+	Bt
		924446 RS27A_BOVIN (685-760): 5.08e-42: 152: 100.00		RS27A_BOVIN (1-77): 1.85e-38: 126: 57.14
+	Hs
		923945 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		RL40_HUMAN (1-76): 3.05e-35: 117: 57.90
+	Hs
		924010 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		NEDD8_HUMAN (1-81): 1.15e-31: 107: 98.77
+	Hs
		397893 ISG15_HUMAN (228-380): 7.21e-29: 115: 32.69		RS27A_HUMAN (1-77): 1.85e-38: 126: 57.14
+	Hs
		474985 UBB_HUMAN (1-77): 1.17e-26: 110: 98.70		RL40_HUMAN (1-76): 3.05e-35: 117: 57.90
+	Hs
		474899 UBB_HUMAN (1-77): 1.17e-26: 110: 98.70		UBB_HUMAN (1-76): 8.19e-32: 111: 57.90
+	Hs
		475036 UBB_HUMAN (1-77): 1.17e-26: 110: 98.70		NEDD8_HUMAN (1-81): 1.15e-31: 107: 98.77