HitPredict

Interactor 1: P55G (Q64143)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: Pik3r3

Interactor 2: PK3CB (Q8BTI9)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)
Gene: Pik3cb

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.34 1.00 0.590

The method score is based on:

Property Details
Experiments 15102471
Identification Methods two hybrid
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~PI3_PI4_kinase, PI3K_C2~PI3K_P85_iSH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3_PI4_kinase~SH2, PI3K_C2~SH2, PI3Ka~SH2
Common GO terms GO:0005942 - phosphatidylinositol 3-kinase complex
GO:0010628 - positive regulation of gene expression
GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 - phosphatidylinositol phosphate biosynthetic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 461
Mm

1 1064
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Bt
+ Mm
+ Hs
+ Hs
+ Dm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024