Protein: CNNM3
Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)

Gene: CNNM3
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q8NE01

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0010960 - magnesium ion homeostasis
GO:0016020 - membrane
GO:0022857 - transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1091825

TP4A2
Protein tyrosine phosphatase type IVA 2

6

10

Small-scale

0.953

High

1337044

TP4A1
Protein tyrosine phosphatase type IVA 1

6

10

Small-scale

0.847

High

277380

TP4A3
Protein tyrosine phosphatase type IVA 3

2

10

Small-scale

0.776

High

1337077

ARL15
ADP-ribosylation factor-like protein 15

3

5

High-throughput

0.751

High

1337082

BTNL2
Butyrophilin-like protein 2

1

3

High-throughput

0.691

High

375739

RASK
GTPase KRas

4

7

High-throughput

0.676

High

698908

CALX
Calnexin

3

2

High-throughput

0.650

High

1116540

FHL3
Four and a half LIM domains protein 3

4

1

High-throughput

0.642

High

374779

RASH
GTPase HRas

3

4

High-throughput

0.640

High

965785

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

0

High-throughput

0.639

High

845729

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.618

High

1326492

ARL14
ADP-ribosylation factor-like protein 14

1

1

High-throughput

0.618

High

685909

KRA59
Keratin-associated protein 5-9

3

12

High-throughput

0.616

High

950585

KR108
Keratin-associated protein 10-8

3

11

High-throughput

0.616

High

950836

KR109
Keratin-associated protein 10-9

3

11

High-throughput

0.616

High

1337061

KRA32
Keratin-associated protein 3-2

3

1

High-throughput

0.616

High

540570

LAMP1
Lysosome-associated membrane glycoprotein 1

3

0

High-throughput

0.616

High

794548

RBMX
RNA-binding motif protein, X chromosome

2

2

High-throughput

0.606

High

1104444

ILK
Scaffold protein ILK

2

0

High-throughput

0.602

High

975134

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.586

High

374073

RASN
GTPase NRas

2

7

High-throughput

0.584

High

978169

RHOB
Rho-related GTP-binding protein RhoB

2

10

High-throughput

0.584

High

652362

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.580

High

1095717

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

2

0

High-throughput

0.580

High

1224865

TENS2
Tensin-2

2

0

High-throughput

0.580

High

1337080

UBQL2
Ubiquilin-2

2

0

High-throughput

0.580

High

269301

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.553

High

284699

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

1

High-throughput

0.553

High

353453

AGR2
Anterior gradient protein 2 homolog

2

1

High-throughput

0.553

High

572080

TRI27
Zinc finger protein RFP

2

1

High-throughput

0.553

High

948360

KR122
Keratin-associated protein 12-2

2

12

High-throughput

0.553

High

949596

KR123
Keratin-associated protein 12-3

2

1

High-throughput

0.553

High

950339

KR107
Keratin-associated protein 10-7

2

10

High-throughput

0.553

High

1016522

SRSF3
Serine/arginine-rich splicing factor 3

2

1

High-throughput

0.553

High

1059695

KRA11
Keratin-associated protein 1-1

2

11

High-throughput

0.553

High

1127665

KT33B
Keratin, type I cuticular Ha3-II

2

2

High-throughput

0.553

High

1146053

K1H1
Keratin, type I cuticular Ha1

2

2

High-throughput

0.553

High

1148280

RBY1F
RNA-binding motif protein, Y chromosome, family 1 member F/J

2

2

High-throughput

0.553

High

1216136

FHL5
Four and a half LIM domains protein 5

2

1

High-throughput

0.553

High

1219118

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

1

High-throughput

0.553

High

1230148

K1C40
Keratin, type I cytoskeletal 40

2

2

High-throughput

0.553

High

1307417

KRA13
Keratin-associated protein 1-3

2

11

High-throughput

0.553

High

1337040

AGR3
Anterior gradient protein 3

2

1

High-throughput

0.553

High

1337058

KRA98
Keratin-associated protein 9-8

2

12

High-throughput

0.553

High

1337059

KRA93
Keratin-associated protein 9-3

2

12

High-throughput

0.553

High

1337060

KRA92
Keratin-associated protein 9-2

2

12

High-throughput

0.553

High

1337062

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.553

High

1337083

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

2

High-throughput

0.553

High

1337084

PNMA3
Paraneoplastic antigen Ma3

2

3

High-throughput

0.553

High

1337085

PNMA2
Paraneoplastic antigen Ma2

2

3

High-throughput

0.553

High

1337055

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.549

High

380321

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

9

High-throughput

0.536

High

380644

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

9

High-throughput

0.536

High

409595

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

9

High-throughput

0.536

High

412277

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.536

High

520930

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.536

High

618402

TSN8
Tetraspanin-8

1

3

High-throughput

0.536

High

749362

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

1

High-throughput

0.536

High

1006024

ASIC1
Acid-sensing ion channel 1

1

3

High-throughput

0.536

High

1116256

PTC1
Protein patched homolog 1

1

3

High-throughput

0.536

High

1245885

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.536

High

1292842

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.536

High

1337048

ASIC4
Acid-sensing ion channel 4

1

3

High-throughput

0.536

High

1337049

TSN17
Tetraspanin-17

1

4

High-throughput

0.536

High

1337051

TSN18
Tetraspanin-18

1

4

High-throughput

0.536

High

1337081

CLC2D
C-type lectin domain family 2 member D

1

5

High-throughput

0.536

High

1337091

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.536

High

505356

KRA23
Keratin-associated protein 2-3

1

12

High-throughput

0.523

High

1336415

PNMA1
Paraneoplastic antigen Ma1

1

3

High-throughput

0.523

High

693034

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

1286835

TM11B
Transmembrane protease serine 11B

1

5

High-throughput

0.515

High

1337087

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.515

High

231330

EFNA2
Ephrin-A2

1

0

High-throughput

0.513

High

351836

BY55
CD160 antigen

1

0

High-throughput

0.513

High

1337052

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.513

High

648593

FGFR4
Fibroblast growth factor receptor 4

1

6

High-throughput

0.500

High

952450

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

1

High-throughput

0.494

High

1337054

KR412
Keratin-associated protein 4-12

1

12

High-throughput

0.494

High

342628

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.489

High

548070

PSPC
Surfactant protein C

1

2

High-throughput

0.489

High

1308902

S22A9
Organic anion transporter 7

1

11

High-throughput

0.489

High

1310241

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

1337065

CST11
Cystatin-11

1

1

High-throughput

0.489

High

1337068

CST9L
Cystatin-9-like

1

1

High-throughput

0.489

High

1337070

SG196
Protein O-mannose kinase

1

1

High-throughput

0.489

High

126703

RHOD
Rho-related GTP-binding protein RhoD

1

12

High-throughput

0.479

High

188942

TMPS2
Transmembrane protease serine 2

1

5

High-throughput

0.479

High

189715

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

218493

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

341106

DIRA3
GTP-binding protein Di-Ras3

1

1

High-throughput

0.479

High

363583

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

466362

RHOC
Rho-related GTP-binding protein RhoC

1

8

High-throughput

0.479

High

581175

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

601376

RHOQ
Rho-related GTP-binding protein RhoQ

1

10

High-throughput

0.479

High

710369

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.479

High

761265

RYK
Tyrosine-protein kinase RYK

1

7

Small-scale

0.479

High

910135

RND2
Rho-related GTP-binding protein RhoN

1

12

High-throughput

0.479

High

932101

EPHA4
Ephrin type-A receptor 4

1

3

High-throughput

0.479

High

953569

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

955385

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

962280

RHOA
Transforming protein RhoA

1

9

High-throughput

0.479

High

962789

RND3
Rho-related GTP-binding protein RhoE

1

12

High-throughput

0.479

High

988534

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

996249

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.479

High

1015609

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

1041182

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1087195

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1145021

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1147383

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.479

High

1151783

RHOH
Rho-related GTP-binding protein RhoH

1

10

High-throughput

0.479

High

1157000

NTRK3
NT-3 growth factor receptor

1

3

High-throughput

0.479

High

1159516

NTRK2
BDNF/NT-3 growth factors receptor

1

4

High-throughput

0.479

High

1249033

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1270905

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.479

High

1334467

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1337064

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1337067

RHOJ
Rho-related GTP-binding protein RhoJ

1

10

High-throughput

0.479

High

1337069

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1337072

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

1337075

TMPS4
Transmembrane protease serine 4

1

5

High-throughput

0.479

High

517064

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

950100

KR105
Keratin-associated protein 10-5

1

11

High-throughput

0.470

High

1337041

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.460

High

299297

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

458448

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

463658

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.458

High

604105

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

715679

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

847607

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

1159760

OCLN
Occludin

1

0

High-throughput

0.458

High

1233360

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1337066

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1337071

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1033933

SC6A3
Sodium-dependent dopamine transporter

1

2

High-throughput

0.445

High

1197841

S39AC
Zinc transporter ZIP12

1

1

High-throughput

0.445

High

1211933

S35F1
Solute carrier family 35 member F1

1

5

High-throughput

0.445

High

1337042

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.445

High

1337063

S22A4
Solute carrier family 22 member 4

1

11

High-throughput

0.445

High

1337073

ANKH
Mineralization regulator ANKH

1

1

High-throughput

0.445

High

1337088

S22AE
Solute carrier family 22 member 14

1

11

High-throughput

0.445

High

1277319

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.439

High

294046

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

831087

CCNF
Cyclin-F

1

2

High-throughput

0.437

High

956403

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.437

High

1293076

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1337045

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1060375

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.426

High

1207879

S27A3
Long-chain fatty acid transport protein 3

1

0

High-throughput

0.426

High

1337047

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.426

High

1337053

MDFI
MyoD family inhibitor

4

0

High-throughput

0.367

High

1330025

USBP1
Harmonin-binding protein USHBP1

3

0

High-throughput

0.352

High

1332403

CBY2
Protein chibby homolog 2

3

0

High-throughput

0.352

High

1337043

RBPMS
RNA-binding protein with multiple splicing

3

0

High-throughput

0.348

High

65105

GG6L9
Golgin subfamily A member 6-like protein 9

2

0

High-throughput

0.316

High

70366

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

351569

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

0

High-throughput

0.316

High

452333

PDIA1
Protein disulfide-isomerase

2

0

High-throughput

0.316

High

773764

ACTN2
Alpha-actinin-2

2

0

High-throughput

0.316

High

885338

HXA1
Homeobox protein Hox-A1

2

0

High-throughput

0.316

High

1180112

VWC2
Brorin

2

0

High-throughput

0.316

High

1205885

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

0

High-throughput

0.316

High

1213781

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.316

High

1315425

P20D2
Xaa-Arg dipeptidase

2

0

High-throughput

0.316

High

1337046

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.316

High

1337056

CAR10
Caspase recruitment domain-containing protein 10

2

0

High-throughput

0.316

High

1337057

KR171
Keratin-associated protein 17-1

2

0

High-throughput

0.316

High

1337078

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.316

High

1337079

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.316

High

1337086

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.316

High

1337089

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

1337090

ZN330
Zinc finger protein 330

2

0

High-throughput

0.316

High

1337074

FBX6
F-box only protein 6

2

0

High-throughput

0.305

High

332544

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.299

High

337181

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

976837

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.279

Low

1289355

ST32C
Serine/threonine-protein kinase 32C

1

0

High-throughput

0.279

Low

1186775

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

579

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

1045539

TF65
Transcription factor p65

1

0

High-throughput

0.251

Low

181722

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.249

Low

976427

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

1337050

FMNL2
Formin-like protein 2

1

0

High-throughput

0.249

Low

1337076

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1337039

ZNT7
Zinc transporter 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025