HitPredict

Interactor 1: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Interactor 2: NLRP3 (Q8R4B8)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37072933, 36238284
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0035591 - signaling adaptor activity
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 442 Mm			1 1033
+	Hs
		1036822 SQSTM_HUMAN (1-442): 0: 715: 89.82		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Hs
		1036917 SQSTM_HUMAN (1-442): 0: 715: 89.82		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		886377 SQSTM_HUMAN (1-442): 0: 715: 89.82		NLRP6_HUMAN (772-1030): 3.44e-18: 92.5: 25.28
+	Hs
		1036704 SQSTM_HUMAN (1-442): 0: 715: 89.82		NLRC5_HUMAN (485-1032): 1.08e-14: 81.3: 14.36
+	Hs
		1037012 SQSTM_HUMAN (1-442): 0: 715: 89.82		NOD1_HUMAN (906-1032): 1.98e-10: 67: 22.05