Protein: UBE2Z
Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)

Gene: UBE2Z
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q9H832

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

48386

UBA6
Ubiquitin-like modifier-activating enzyme 6

11

20

Small-scale

0.976

High

242944

PRKN
E3 ubiquitin-protein ligase parkin

4

20

Small-scale

0.882

High

182002

UBD
Ubiquitin D

3

20

Small-scale

0.849

High

647660

UBA1
Ubiquitin-like modifier-activating enzyme 1

3

20

Small-scale

0.845

High

1391045

OTUB1
Ubiquitin thioesterase OTUB1

1

11

Small-scale

0.756

High

279071

TRIM3
Tripartite motif-containing protein 3

2

20

High-throughput

0.700

High

128516

RN103
E3 ubiquitin-protein ligase RNF103

1

20

High-throughput

0.698

High

1028396

MDM2
E3 ubiquitin-protein ligase Mdm2

1

15

High-throughput

0.698

High

1116806

RAPSN
43 kDa receptor-associated protein of the synapse

1

1

High-throughput

0.698

High

1127764

HLTF
Helicase-like transcription factor

1

11

High-throughput

0.698

High

1278000

R144B
E3 ubiquitin-protein ligase RNF144B

1

20

High-throughput

0.698

High

1287447

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

High-throughput

0.698

High

1294261

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.698

High

1356233

RN139
E3 ubiquitin-protein ligase RNF139

1

20

High-throughput

0.698

High

1382343

RN166
E3 ubiquitin-protein ligase RNF166

1

20

High-throughput

0.698

High

1408199

RNF5
E3 ubiquitin-protein ligase RNF5

1

20

High-throughput

0.698

High

1416098

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

10

High-throughput

0.698

High

1434403

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

High-throughput

0.698

High

1436071

RN150
RING finger protein 150

1

20

High-throughput

0.698

High

1245065

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

High-throughput

0.656

High

1280504

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

Small-scale

0.647

High

1278502

TRI46
Tripartite motif-containing protein 46

1

20

High-throughput

0.625

High

1294570

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.625

High

1325758

LNX2
Ligand of Numb protein X 2

1

7

High-throughput

0.625

High

508639

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.618

High

1254277

UBR3
E3 ubiquitin-protein ligase UBR3

1

8

Small-scale

0.618

High

1311110

UBR1
E3 ubiquitin-protein ligase UBR1

1

8

Small-scale

0.618

High

1311177

UBR2
E3 ubiquitin-protein ligase UBR2

1

8

Small-scale

0.618

High

1436070

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

1436064

PKHF2
Pleckstrin homology domain-containing family F member 2

3

2

High-throughput

0.609

High

882165

TCPG
T-complex protein 1 subunit gamma

2

1

High-throughput

0.606

High

1081485

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1090921

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.590

High

1348508

LNX1
E3 ubiquitin-protein ligase LNX

1

7

High-throughput

0.590

High

1418394

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.575

High

1049002

REL
Proto-oncogene c-Rel

1

9

High-throughput

0.573

High

1436072

PKHA6
Pleckstrin homology domain-containing family A member 6

2

6

High-throughput

0.553

High

1238123

HMBX1
Homeobox-containing protein 1

1

0

High-throughput

0.549

High

1397941

KAD8
Adenylate kinase 8

1

0

High-throughput

0.549

High

572218

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.541

High

274760

DNJB6
DnaJ homolog subfamily B member 6

1

6

High-throughput

0.536

High

921571

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

2

High-throughput

0.536

High

1436066

PKHA2
Pleckstrin homology domain-containing family A member 2

1

2

High-throughput

0.536

High

1288860

GTD2A
General transcription factor II-I repeat domain-containing protein 2A

1

0

High-throughput

0.513

High

1397112

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.513

High

967977

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

9

Small-scale

0.508

High

347936

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

607111

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

1137159

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

3

High-throughput

0.479

High

1192963

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

3

High-throughput

0.479

High

1432970

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1436069

ZRAN1
Ubiquitin thioesterase ZRANB1

1

20

High-throughput

0.479

High

1256823

STOX1
Storkhead-box protein 1

1

0

High-throughput

0.458

High

960566

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.457

High

1162765

KGUA
Guanylate kinase

1

1

High-throughput

0.457

High

1402307

RANB9
Ran-binding protein 9

1

9

High-throughput

0.457

High

259114

DNJA2
DnaJ homolog subfamily A member 2

1

4

High-throughput

0.445

High

330322

VENTX
Homeobox protein VENTX

1

5

High-throughput

0.445

High

1209666

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.445

High

1315716

DND1
Dead end protein homolog 1

1

2

High-throughput

0.445

High

1436068

DDX28
Probable ATP-dependent RNA helicase DDX28

1

5

High-throughput

0.445

High

1260320

INT8
Integrator complex subunit 8

1

0

High-throughput

0.438

High

1436067

SRA1
Steroid receptor RNA activator 1

1

0

High-throughput

0.438

High

106662

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1255567

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

143760

WN10B
Protein Wnt-10b

1

0

High-throughput

0.426

High

404916

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1328126

TTC9C
Tetratricopeptide repeat protein 9C

1

4

High-throughput

0.407

High

1397167

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

6

High-throughput

0.407

High

1436065

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.316

High

449540

LIPL
Lipoprotein lipase

1

0

High-throughput

0.282

High

1388940

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.269

Low

295769

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.238

Low

337819

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.232

Low

638522

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.232

Low

1104108

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1382664

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025