Protein: SYNE2
Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)

Gene: SYNE2
Organism: Homo sapiens
Interactions: 175
UniProt ID: Q8WXH0

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005640 - nuclear outer membrane
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1263736

SUN2
SUN domain-containing protein 2

5

13

Small-scale

0.939

High

1168607

SYNE3
Nesprin-3

2

20

Small-scale

0.737

High

299698

SUN1
SUN domain-containing protein 1

1

13

Small-scale

0.730

High

932288

ACTC
Actin, alpha cardiac muscle 1

1

17

Small-scale

0.647

High

310739

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

4

High-throughput

0.628

High

1263734

VAPA
Vesicle-associated membrane protein-associated protein A

2

4

High-throughput

0.628

High

647639

MK03
Mitogen-activated protein kinase 3

2

7

Small-scale

0.624

High

659012

MK01
Mitogen-activated protein kinase 1

2

7

Small-scale

0.624

High

1171013

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

847579

BAP31
B-cell receptor-associated protein 31

2

1

High-throughput

0.611

High

1064531

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

5

High-throughput

0.611

High

1263745

CAN6
Calpain-6

2

0

High-throughput

0.602

High

839017

EMD
Emerin

2

3

Small-scale

0.601

High

1190816

BRAP
BRCA1-associated protein

2

8

Small-scale

0.595

High

476118

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

11

Small-scale

0.595

High

1263703

LRC59
Leucine-rich repeat-containing protein 59

2

7

High-throughput

0.584

High

1244119

SYNE1
Nesprin-1

1

16

Small-scale

0.575

High

131266

BIN1
Myc box-dependent-interacting protein 1

1

10

Small-scale

0.573

High

668858

PML
Protein PML

1

6

Small-scale

0.561

High

717239

CTNB1
Catenin beta-1

1

7

Small-scale

0.561

High

1131788

CE170
Centrosomal protein of 170 kDa

2

16

High-throughput

0.558

High

1224622

ABI1
Abl interactor 1

1

11

High-throughput

0.541

High

1263739

DP13A
DCC-interacting protein 13-alpha

1

2

High-throughput

0.541

High

124027

SPT5H
Transcription elongation factor SPT5

1

3

High-throughput

0.536

High

197062

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

7

High-throughput

0.536

High

538737

HXB2
Homeobox protein Hox-B2

1

1

High-throughput

0.536

High

642973

S10A4
Protein S100-A4

1

3

High-throughput

0.536

High

686019

ARRB2
Beta-arrestin-2

1

2

High-throughput

0.536

High

740222

NUP62
Nuclear pore glycoprotein p62

1

5

High-throughput

0.536

High

868648

ATX1
Ataxin-1

1

1

High-throughput

0.536

High

1038576

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.536

High

1049432

MORC3
MORC family CW-type zinc finger protein 3

1

2

High-throughput

0.536

High

1082897

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.536

High

1263705

HDA11
Histone deacetylase 11

1

13

High-throughput

0.536

High

1263729

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

1263737

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

1263711

SEC62
Translocation protein SEC62

2

3

High-throughput

0.533

High

1263744

FHOD1
FH1/FH2 domain-containing protein 1

1

3

Small-scale

0.529

High

119660

STXB3
Syntaxin-binding protein 3

1

5

High-throughput

0.515

High

418500

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

502377

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.515

High

944346

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.515

High

1151152

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

217732

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.513

High

265918

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.513

High

336562

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

1136022

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

1221186

NRM
Nurim

1

0

High-throughput

0.513

High

1032932

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

3

High-throughput

0.508

High

776763

STAT3
Signal transducer and activator of transcription 3

1

5

High-throughput

0.500

High

913656

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.493

High

253903

LRP3
Low-density lipoprotein receptor-related protein 3

1

6

High-throughput

0.489

High

656964

5HT1B
5-hydroxytryptamine receptor 1B

1

5

High-throughput

0.489

High

1237916

GBP7
Guanylate-binding protein 7

1

2

High-throughput

0.489

High

299120

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.481

High

838167

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

120562

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

131021

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

155059

NDC80
Kinetochore protein NDC80 homolog

1

15

High-throughput

0.479

High

163907

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.479

High

177956

TMPS2
Transmembrane protease serine 2

1

8

High-throughput

0.479

High

178700

STX7
Syntaxin-7

1

8

High-throughput

0.479

High

228200

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

255954

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

273916

NU155
Nuclear pore complex protein Nup155

1

4

High-throughput

0.479

High

308932

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

315208

CNEP1
CTD nuclear envelope phosphatase 1

1

2

High-throughput

0.479

High

360220

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

Small-scale

0.479

High

364378

TFR1
Transferrin receptor protein 1

1

5

High-throughput

0.479

High

377536

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

387195

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

430283

PROF1
Profilin-1

1

4

High-throughput

0.479

High

436435

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

441759

CFAH
Complement factor H

1

4

Small-scale

0.479

High

504478

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

527670

LAMP2
Lysosome-associated membrane glycoprotein 2

1

14

High-throughput

0.479

High

545007

AMPN
Aminopeptidase N

1

3

High-throughput

0.479

High

545530

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

567199

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

573826

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

4

High-throughput

0.479

High

591646

RAB3B
Ras-related protein Rab-3B

1

7

High-throughput

0.479

High

591956

RAB4A
Ras-related protein Rab-4A

1

12

High-throughput

0.479

High

592406

RAB5A
Ras-related protein Rab-5A

1

14

High-throughput

0.479

High

742435

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

786046

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

825488

LMAN1
Protein ERGIC-53

1

6

High-throughput

0.479

High

845115

RAB7A
Ras-related protein Rab-7a

1

15

High-throughput

0.479

High

845639

RAB9A
Ras-related protein Rab-9A

1

18

High-throughput

0.479

High

869695

TERF1
Telomeric repeat-binding factor 1

1

11

High-throughput

0.479

High

894261

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

897187

TM258
Transmembrane protein 258

1

3

Small-scale

0.479

High

900744

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

904924

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

914251

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.479

High

927350

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

940511

CXAR
Coxsackievirus and adenovirus receptor

1

6

High-throughput

0.479

High

951192

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

961212

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

961754

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.479

High

982336

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

990580

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

1017734

STX4
Syntaxin-4

1

8

High-throughput

0.479

High

1040187

STIM1
Stromal interaction molecule 1

1

4

High-throughput

0.479

High

1053103

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.479

High

1061521

CUL7
Cullin-7

1

10

High-throughput

0.479

High

1070326

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.479

High

1074952

TERF2
Telomeric repeat-binding factor 2

1

11

High-throughput

0.479

High

1198113

TM11B
Transmembrane protease serine 11B

1

8

High-throughput

0.479

High

1240229

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.479

High

1243338

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1244399

NUP43
Nucleoporin Nup43

1

10

High-throughput

0.479

High

1263700

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1263701

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

4

High-throughput

0.479

High

1263702

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.479

High

1263704

OPTN
Optineurin

1

20

High-throughput

0.479

High

1263706

DNJC1
DnaJ homolog subfamily C member 1

1

13

High-throughput

0.479

High

1263710

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

4

High-throughput

0.479

High

1263714

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.479

High

1263717

VP33B
Vacuolar protein sorting-associated protein 33B

1

6

High-throughput

0.479

High

1263718

GAN
Gigaxonin

1

8

High-throughput

0.479

High

1263722

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

1263724

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.479

High

1263727

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.479

High

1263730

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

High-throughput

0.479

High

1263731

MKS1
Tectonic-like complex member MKS1

1

1

Small-scale

0.479

High

1263741

LAMP3
Lysosome-associated membrane glycoprotein 3

1

14

High-throughput

0.479

High

1263743

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

2

Small-scale

0.479

High

1058371

MESD
LRP chaperone MESD

1

1

High-throughput

0.470

High

1205165

CONA1

1

2

High-throughput

0.470

High

825723

MTR1B
Melatonin receptor type 1B

1

11

High-throughput

0.464

High

262054

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

514709

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

900215

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

904056

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.458

High

958980

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1135097

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1263732

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.458

High

225244

3BP5
SH3 domain-binding protein 5

1

3

High-throughput

0.457

High

497354

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.457

High

1263712

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.457

High

1263715

NDEL1
Nuclear distribution protein nudE-like 1

1

20

High-throughput

0.457

High

1263725

DISC1
Disrupted in schizophrenia 1 protein

1

9

High-throughput

0.457

High

1263728

EXOC1
Exocyst complex component 1

1

3

High-throughput

0.457

High

1263738

TNIK
TRAF2 and NCK-interacting protein kinase

1

20

High-throughput

0.457

High

402288

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

882464

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

High-throughput

0.445

High

48440

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.437

High

149115

CTRO
Citron Rho-interacting kinase

1

13

High-throughput

0.437

High

390411

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.437

High

391057

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.437

High

795217

SSRA
Translocon-associated protein subunit alpha

1

3

High-throughput

0.437

High

852572

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.437

High

890299

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.437

High

1230304

CXD3
Gap junction delta-3 protein

1

14

High-throughput

0.437

High

1256003

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.437

High

1263699

CLC4D
C-type lectin domain family 4 member D

1

8

High-throughput

0.437

High

1263713

DERL1
Derlin-1

1

1

High-throughput

0.437

High

1263716

DJC25
DnaJ homolog subfamily C member 25

1

7

High-throughput

0.437

High

1263719

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

1263720

TMT1A
Thiol S-methyltransferase TMT1A

1

4

High-throughput

0.437

High

1263721

ANM8
Protein arginine N-methyltransferase 8

1

6

Small-scale

0.437

High

1263723

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1263726

TMPS4
Transmembrane protease serine 4

1

8

High-throughput

0.437

High

1263733

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.437

High

1263735

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.437

High

1263740

CLC4E
C-type lectin domain family 4 member E

1

8

High-throughput

0.437

High

1263742

DJC16
DnaJ homolog subfamily C member 16

1

11

High-throughput

0.437

High

1079765

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

1255289

MIPT3
TRAF3-interacting protein 1

1

7

High-throughput

0.417

High

1263708

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.417

High

1263707

C170L
Cep170-like protein

1

3

High-throughput

0.407

High

1126114

MKS3
Meckelin

1

0

Small-scale

0.292

High

1139543

SLX4I
Protein SLX4IP

1

0

High-throughput

0.279

Low

1252974

TBC16
TBC1 domain family member 16

1

0

High-throughput

0.279

Low

1263709

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024