Protein: RFOX2
RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity)

Gene: RFOX2, RBFOX2
Organism: Homo sapiens
Interactions: 237
UniProt ID: O43251

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0003714 - transcription corepressor activity
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211382

RBPMS
RNA-binding protein with multiple splicing

8

6

High-throughput

0.970

High

211349

RBPS2
RNA-binding protein with multiple splicing 2

5

6

High-throughput

0.926

High

211291

HNRPF
Heterogeneous nuclear ribonucleoprotein F

4

18

High-throughput

0.908

High

211365

BOLL
Protein boule-like

4

19

High-throughput

0.901

High

211274

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

3

19

High-throughput

0.861

High

211418

RBM38
RNA-binding protein 38

3

20

High-throughput

0.861

High

211385

MSI2H
RNA-binding protein Musashi homolog 2

3

19

High-throughput

0.849

High

211430

MBNL1
Muscleblind-like protein 1

3

3

High-throughput

0.849

High

211437

RFOX1
RNA binding protein fox-1 homolog 1

2

17

High-throughput

0.815

High

211235

RFOX2
RNA binding protein fox-1 homolog 2

2

16

High-throughput

0.801

High

211276

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

17

High-throughput

0.783

High

211453

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

2

High-throughput

0.783

High

211411

RBM42
RNA-binding protein 42

2

20

High-throughput

0.768

High

211320

DAZP2
DAZ-associated protein 2

7

2

High-throughput

0.752

High

211396

QKI
KH domain-containing RNA-binding protein QKI

7

19

High-throughput

0.751

High

211313

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.740

High

211293

ATX1
Ataxin-1

5

5

High-throughput

0.730

High

65292

RFOX3
RNA binding protein fox-1 homolog 3

1

17

Small-scale

0.724

High

211282

HELZ
Probable helicase with zinc finger domain

2

12

High-throughput

0.712

High

162396

ANM5
Protein arginine N-methyltransferase 5

4

15

Small-scale

0.703

High

211456

FBX7
F-box only protein 7

4

4

Small-scale

0.703

High

211310

ELAV2
ELAV-like protein 2

1

19

High-throughput

0.698

High

211403

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

20

High-throughput

0.698

High

211407

RHXF2
Rhox homeobox family member 2

4

3

High-throughput

0.692

High

211236

MSI1H
RNA-binding protein Musashi homolog 1

1

20

High-throughput

0.691

High

211326

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

19

High-throughput

0.691

High

211345

PKN3
Serine/threonine-protein kinase N3

1

6

High-throughput

0.691

High

211398

PSKH2
Serine/threonine-protein kinase H2

1

7

High-throughput

0.691

High

211244

RNF8
E3 ubiquitin-protein ligase RNF8

3

7

High-throughput

0.675

High

211458

MAGD1
Melanoma-associated antigen D1

3

13

High-throughput

0.675

High

211237

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

3

11

High-throughput

0.667

High

211292

ICLN
Methylosome subunit pICln

3

2

High-throughput

0.667

High

211318

PUM1
Pumilio homolog 1

3

10

High-throughput

0.667

High

211334

FND3B
Fibronectin type III domain-containing protein 3B

3

8

High-throughput

0.667

High

211371

PUM2
Pumilio homolog 2

3

10

High-throughput

0.667

High

211384

F136A
Protein FAM136A

3

1

High-throughput

0.667

High

211402

ATX2
Ataxin-2

3

15

High-throughput

0.667

High

211408

RIOK1
Serine/threonine-protein kinase RIO1

3

5

High-throughput

0.667

High

211423

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

3

4

High-throughput

0.667

High

211428

COPRS
Coordinator of PRMT5 and differentiation stimulator

3

2

High-throughput

0.667

High

211447

GPTC8
G patch domain-containing protein 8

3

4

High-throughput

0.667

High

211271

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.656

High

211272

PTBP1
Polypyrimidine tract-binding protein 1

1

18

High-throughput

0.656

High

211296

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

17

High-throughput

0.656

High

211329

ELAV1
ELAV-like protein 1

1

17

High-throughput

0.656

High

211356

RBM23
Probable RNA-binding protein 23

1

19

High-throughput

0.656

High

211436

RBM22
Pre-mRNA-splicing factor RBM22

1

17

High-throughput

0.656

High

211262

ATX1L
Ataxin-1-like

3

5

High-throughput

0.654

High

211322

PCBP1
Poly(rC)-binding protein 1

3

20

High-throughput

0.654

High

211393

DMRTB
Doublesex- and mab-3-related transcription factor B1

3

2

High-throughput

0.639

High

211387

TRM61
tRNA

3

0

High-throughput

0.638

High

211419

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

3

0

High-throughput

0.638

High

211443

PKHB1
Pleckstrin homology domain-containing family B member 1

3

0

High-throughput

0.638

High

211259

SNRPA
U1 small nuclear ribonucleoprotein A

1

19

High-throughput

0.621

High

211275

PDIA3
Protein disulfide-isomerase A3

1

4

High-throughput

0.621

High

211324

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.621

High

211325

SF3B4
Splicing factor 3B subunit 4

1

19

High-throughput

0.621

High

211328

SF01
Splicing factor 1

1

19

High-throughput

0.621

High

211364

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

18

High-throughput

0.621

High

211373

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

5

High-throughput

0.621

High

211389

SPF45
Splicing factor 45

1

18

High-throughput

0.621

High

211433

RBM12
RNA-binding protein 12

1

17

High-throughput

0.621

High

211461

RPKL1
Ribosomal protein S6 kinase-like 1

1

9

High-throughput

0.618

High

132413

CDC7
Cell division cycle 7-related protein kinase

1

8

High-throughput

0.618

High

211261

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

High-throughput

0.618

High

211317

RBM39
RNA-binding protein 39

1

19

High-throughput

0.618

High

211379

LAR4B
La-related protein 4B

1

20

High-throughput

0.618

High

211399

PHF12
PHD finger protein 12

1

14

High-throughput

0.618

High

211425

RC3H2
Roquin-2

1

16

High-throughput

0.618

High

211427

BRD7
Bromodomain-containing protein 7

2

12

High-throughput

0.614

High

211315

CUL3
Cullin-3

2

20

High-throughput

0.611

High

211454

BCS1
Mitochondrial chaperone BCS1

3

11

High-throughput

0.609

High

211266

HMGA1
High mobility group protein HMG-I/HMG-Y

2

1

High-throughput

0.606

High

211358

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

12

High-throughput

0.606

High

211391

SMIP9
Protein SPMIP9

2

1

High-throughput

0.606

High

211445

UBQL2
Ubiquilin-2

2

6

High-throughput

0.606

High

211260

RU1C
U1 small nuclear ribonucleoprotein C

2

5

High-throughput

0.595

High

211307

VAC14
Protein VAC14 homolog

2

10

High-throughput

0.590

High

211378

PSMF1
Proteasome inhibitor PI31 subunit

2

1

High-throughput

0.590

High

211352

NOL8
Nucleolar protein 8

1

0

High-throughput

0.589

High

211390

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.589

High

211246

KI20A
Kinesin-like protein KIF20A

2

20

High-throughput

0.586

High

136029

PLK4
Serine/threonine-protein kinase PLK4

1

8

High-throughput

0.575

High

211248

PTBP3
Polypyrimidine tract-binding protein 3

1

18

High-throughput

0.575

High

211308

NCBP1
Nuclear cap-binding protein subunit 1

1

5

High-throughput

0.575

High

211424

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.575

High

211252

ESR1
Estrogen receptor

1

20

Small-scale

0.573

High

211242

DAB1
Disabled homolog 1

1

2

High-throughput

0.573

High

211270

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.573

High

211249

MYC
Myc proto-oncogene protein

2

19

High-throughput

0.571

High

211264

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

6

High-throughput

0.571

High

211351

TBA1A
Tubulin alpha-1A chain

2

9

High-throughput

0.571

High

211405

SH3G3
Endophilin-A3

2

9

High-throughput

0.571

High

50307

F168B
Myelin-associated neurite-outgrowth inhibitor

2

5

High-throughput

0.553

High

211372

OXER1
Oxoeicosanoid receptor 1

2

1

High-throughput

0.553

High

211388

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.549

High

211238

MED7
Mediator of RNA polymerase II transcription subunit 7

1

1

High-throughput

0.541

High

211311

CAF1A
Chromatin assembly factor 1 subunit A

1

3

High-throughput

0.541

High

211414

GLIS2
Zinc finger protein GLIS2

1

4

Small-scale

0.541

High

211417

TOLIP
Toll-interacting protein

1

1

High-throughput

0.541

High

211459

NR2E3
Photoreceptor-specific nuclear receptor

1

17

High-throughput

0.541

High

211269

APC
Adenomatous polyposis coli protein

1

17

High-throughput

0.536

High

211284

MATR3
Matrin-3

1

17

High-throughput

0.536

High

211346

BCOR
BCL-6 corepressor

1

14

Small-scale

0.536

High

211357

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

20

High-throughput

0.536

High

211381

RENT1
Regulator of nonsense transcripts 1

1

12

High-throughput

0.536

High

211421

ESRP2
Epithelial splicing regulatory protein 2

1

17

High-throughput

0.536

High

211440

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

9

High-throughput

0.536

High

211380

ESR2
Estrogen receptor beta

1

20

Small-scale

0.527

High

211343

CA094
Uncharacterized protein C1orf94

1

3

High-throughput

0.523

High

211367

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

4

High-throughput

0.523

High

211332

PKHG6
Pleckstrin homology domain-containing family G member 6

2

9

High-throughput

0.521

High

211257

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.518

High

211377

DEDD2
DNA-binding death effector domain-containing protein 2

1

0

High-throughput

0.518

High

211450

TF2AY
TFIIA-alpha and beta-like factor

1

0

High-throughput

0.518

High

211283

HD
Huntingtin

1

3

High-throughput

0.515

High

211267

DDX5
Probable ATP-dependent RNA helicase DDX5

1

9

High-throughput

0.508

High

211294

ATN1
Atrophin-1

1

15

High-throughput

0.508

High

211297

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

20

High-throughput

0.508

High

211305

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

19

High-throughput

0.508

High

211327

SF3A1
Splicing factor 3A subunit 1

1

6

High-throughput

0.508

High

211330

SMN
Survival motor neuron protein

1

4

High-throughput

0.508

High

211441

RERE
Arginine-glutamic acid dipeptide repeats protein

1

6

High-throughput

0.508

High

185266

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

211394

SFXN2
Sideroflexin-2

1

1

High-throughput

0.489

High

123512

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.481

High

211239

SPOP
Speckle-type POZ protein

1

6

Small-scale

0.481

High

211247

BAG4
BAG family molecular chaperone regulator 4

1

4

High-throughput

0.481

High

211251

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.481

High

211256

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.481

High

211263

H14
Histone H1.4

1

8

High-throughput

0.481

High

211280

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.481

High

211281

RL3
Large ribosomal subunit protein uL3

1

3

High-throughput

0.481

High

211287

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.481

High

211290

F10A1
Hsc70-interacting protein

1

6

High-throughput

0.481

High

211298

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.481

High

211300

RS28
Small ribosomal subunit protein eS28

1

1

High-throughput

0.481

High

211301

RED1
Double-stranded RNA-specific editase 1

1

20

High-throughput

0.481

High

211314

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.481

High

211323

PCBP2
Poly(rC)-binding protein 2

1

20

High-throughput

0.481

High

211336

PRC2B
Protein PRRC2B

1

19

High-throughput

0.481

High

211338

PR38B
Pre-mRNA-splicing factor 38B

1

4

High-throughput

0.481

High

211340

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

19

High-throughput

0.481

High

211354

YTHD3
YTH domain-containing family protein 3

1

12

High-throughput

0.481

High

211359

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

6

High-throughput

0.481

High

211369

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

14

High-throughput

0.481

High

211376

PCNP
PEST proteolytic signal-containing nuclear protein

1

1

High-throughput

0.481

High

211397

PURB
Transcriptional regulator protein Pur-beta

1

4

High-throughput

0.481

High

211410

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.481

High

211413

YTHD1
YTH domain-containing family protein 1

1

12

High-throughput

0.481

High

211429

DDX21
Nucleolar RNA helicase 2

1

19

High-throughput

0.481

High

211432

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.481

High

211442

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.481

High

211444

SRP68
Signal recognition particle subunit SRP68

1

3

High-throughput

0.481

High

211449

PRP19
Pre-mRNA-processing factor 19

1

9

High-throughput

0.481

High

211452

PA2G4
Proliferation-associated protein 2G4

1

3

High-throughput

0.481

High

211457

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

2

High-throughput

0.481

High

142728

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

211240

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

211245

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

3

High-throughput

0.479

High

211250

RASK
GTPase KRas

1

9

High-throughput

0.479

High

211253

GCR
Glucocorticoid receptor

1

20

Small-scale

0.479

High

211254

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.479

High

211258

NFIC
Nuclear factor 1 C-type

1

11

High-throughput

0.479

High

211265

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.479

High

211268

HXA5
Homeobox protein Hox-A5

1

3

High-throughput

0.479

High

211273

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

211277

BMI1
Polycomb complex protein BMI-1

1

19

High-throughput

0.479

High

211278

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

211279

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

211285

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

211288

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.479

High

211289

PRC2A
Protein PRRC2A

1

20

High-throughput

0.479

High

211295

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

211299

H4
Histone H4

1

5

High-throughput

0.479

High

211302

OTUD4
OTU domain-containing protein 4

1

9

High-throughput

0.479

High

211303

MECOM
Histone-lysine N-methyltransferase MECOM

1

6

High-throughput

0.479

High

211309

NFIA
Nuclear factor 1 A-type

1

9

High-throughput

0.479

High

211312

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

7

High-throughput

0.479

High

211335

PKHG4
Puratrophin-1

1

7

High-throughput

0.479

High

211337

UBAP2
Ubiquitin-associated protein 2

1

6

High-throughput

0.479

High

211350

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

211353

ARHG8
Neuroepithelial cell-transforming gene 1 protein

1

12

High-throughput

0.479

High

211362

DOCK3
Dedicator of cytokinesis protein 3

1

4

High-throughput

0.479

High

211370

PJA1
E3 ubiquitin-protein ligase Praja-1

1

7

High-throughput

0.479

High

211374

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

211375

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

211386

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

14

High-throughput

0.479

High

211392

CI072
Guanine nucleotide exchange factor C9orf72

1

6

High-throughput

0.479

High

211404

ANM1
Protein arginine N-methyltransferase 1

1

15

High-throughput

0.479

High

211415

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

High-throughput

0.479

High

211416

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

211420

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

211446

XPO7
Exportin-7

1

8

High-throughput

0.479

High

211448

VAV3
Guanine nucleotide exchange factor VAV3

1

9

High-throughput

0.479

High

211451

CE164
Centrosomal protein of 164 kDa

1

10

High-throughput

0.479

High

211455

FBW1A
F-box/WD repeat-containing protein 1A

1

13

High-throughput

0.479

High

211460

ORNT1
Mitochondrial ornithine transporter 1

1

4

High-throughput

0.470

High

211241

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.460

High

211243

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.460

High

211355

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.460

High

211361

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

1

0

High-throughput

0.460

High

211368

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.460

High

211412

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.460

High

211434

SPS2L
SPATS2-like protein

1

0

High-throughput

0.460

High

211360

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

211395

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

211422

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

211438

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

211306

KLC1
Kinesin light chain 1

1

8

High-throughput

0.445

High

211316

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

211400

TSNAX
Translin-associated protein X

1

1

High-throughput

0.445

High

211304

CALD1
Caldesmon

1

10

High-throughput

0.439

High

211321

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.439

High

211344

DEN1B
DENN domain-containing protein 1B

1

1

High-throughput

0.439

High

211426

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

11

High-throughput

0.439

High

211255

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

211331

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

211339

ARHGG
Rho guanine nucleotide exchange factor 16

1

4

High-throughput

0.437

High

211341

FBW10
F-box/WD repeat-containing protein 10

1

14

High-throughput

0.437

High

211348

RHG36
Rho GTPase-activating protein 36

1

5

High-throughput

0.437

High

211363

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

138

A0A024R6X4
PLEKHG4

1

7

High-throughput

0.407

High

211286

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.407

High

211366

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

211431

S17A5
Sialin

1

1

High-throughput

0.407

High

211342

ANR40
Ankyrin repeat domain-containing protein 40

3

0

High-throughput

0.347

High

211406

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

3

0

High-throughput

0.347

High

211409

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

3

0

High-throughput

0.347

High

211333

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

211439

NLGN3
Neuroligin-3

1

0

High-throughput

0.282

High

211383

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.251

Low

211401

C560
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

1

0

High-throughput

0.251

Low

211435

GIMA4
GTPase IMAP family member 4

1

0

High-throughput

0.251

Low

211319

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

211347

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025