HitPredict

Interactor 1: E4F1 (Q66K89)
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
Gene: E4F1

Interactor 2: GZF1 (Q9H116)
GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336)
Gene: GZF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains zf-C2H2~zf-C2H2
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 1 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 784
Hs

1 711
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024