HitPredict

Interactor 1: RNF43 (Q68DV7)
E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43)
Gene: RNF43

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	34702444
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 783 Hs			1 347
+	Hs
		1148190 RNF43_HUMAN (1-783): 0: 711: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		1078840 RNF43_HUMAN (1-783): 0: 711: 100.00		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		1148119 RNF43_HUMAN (1-783): 0: 711: 100.00		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83
+	Hs
		924635 RNF43_HUMAN (1-783): 0: 711: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		610496 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		610495 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		610400 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		1198711 SYVN1_HUMAN (186-595): 1.11e-42: 166: 15.57		PACN2_HUMAN (1-343): 3.2e-38: 143: 16.45
+	Mm
		610657 CBL_MOUSE (272-682): 5.02e-63: 229: 14.42		ITSN2_MOUSE (14-341): 1.76e-12: 70.8: 11.92
+	Mm
		610595 CBL_MOUSE (272-682): 5.02e-63: 229: 14.42		SRBS2_MOUSE (243-342): 8.22e-12: 68.5: 20.59
+	Mm
		610656 CBL_MOUSE (272-682): 5.02e-63: 229: 14.42		ITSN1_MOUSE (253-341): 8.49e-12: 68.5: 23.60
+	Mm
		610598 CBL_MOUSE (272-682): 5.02e-63: 229: 14.42		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Rn
		88774 D3ZV15_RAT (272-682): 3.86e-60: 221: 14.66		GRB2_RAT (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		1322161 SYVN1_MOUSE (186-595): 5.45e-36: 146: 14.18		PACN2_MOUSE (1-343): 7.01e-37: 140: 16.45
+	Hs
		610501 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		SRBS1_HUMAN (169-342): 1.13e-13: 74.1: 17.65
+	Hs
		610415 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		610338 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		610437 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		Q6ICN0_HUMAN (290-346): 9.74e-12: 65.5: 41.38
+	Hs
		298949 CBL_HUMAN (272-682): 4.13e-48: 185: 14.42		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15