HitPredict

Interactor 1: K1C40 (Q6A162)
Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)
Gene: KRT40

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 431 Hs			1 594
+	Hs
		1149423 K1C39_HUMAN (2-430): 3.23e-153: 444: 50.11		SHC3_HUMAN (1-594): 0: 587: 100.00
+	Hs
		280673 KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53		SHC3_HUMAN (1-594): 0: 587: 100.00
+	Hs
		359306 K1C14_HUMAN (87-400): 4.31e-146: 425: 53.82		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		1055072 KT33B_HUMAN (23-429): 5.43e-111: 333: 58.48		SHC3_HUMAN (1-594): 0: 587: 100.00
+	Hs
		666076 K1C17_HUMAN (82-401): 2.06e-100: 307: 52.81		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		445008 K1C16_HUMAN (85-412): 2.56e-96: 298: 51.52		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		1115793 K1C39_HUMAN (2-430): 3.23e-153: 444: 50.11		Q49AR9_HUMAN (11-496): 2.27e-59: 209: 13.08
+	Hs
		280597 KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53		Q49AR9_HUMAN (11-496): 2.27e-59: 209: 13.08
+	Hs
		1149424 K1C39_HUMAN (2-430): 3.23e-153: 444: 50.11		ANS1A_HUMAN (11-377): 5.8e-54: 200: 15.78
+	Hs
		280675 KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53		ANS1A_HUMAN (11-377): 5.8e-54: 200: 15.78
+	Hs
		280510 KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Mm
		403456 K2C5_MOUSE (60-411): 1.57e-146: 430: 26.33		SRC_MOUSE (361-594): 1.83e-49: 181: 17.46
+	Hs
		280559 KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		359329 K1C14_HUMAN (87-400): 4.31e-146: 425: 53.82		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Mm
		403444 K1C14_MOUSE (88-400): 3.03e-95: 296: 52.72		SRC_MOUSE (361-594): 1.83e-49: 181: 17.46
+	Hs
		280492 KT33A_HUMAN (26-429): 3.98e-112: 337: 60.15		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		924574 KT33B_HUMAN (23-429): 5.43e-111: 333: 58.48		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		444346 K1C19_HUMAN (82-397): 4.55e-103: 313: 51.90		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		924493 K1C17_HUMAN (82-401): 2.06e-100: 307: 52.81		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		445027 K1C16_HUMAN (85-412): 2.56e-96: 298: 51.52		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08