HitPredict
Protein: SHH
Sonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]

Gene: SHH
Organism: Homo sapiens
Interactions: 12
UniProt ID: Q15465

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001570 - vasculogenesis
GO:0001656 - metanephros development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score		 Confidence

1149261

 HHIP
Hedgehog-interacting protein

1

4

Small-scale

 0.761

High

1116206

 PTC1
Protein patched homolog 1

5

3

Small-scale

 0.716

High

1149258

 SHH
Sonic hedgehog protein

1

1

Small-scale

 0.691

High

1149260

 EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

Small-scale

 0.479

High

1149262

 DERL1
Derlin-1

1

1

Small-scale

 0.479

High

1149263

 EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

2

Small-scale

 0.479

High

1149264

 EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

2

Small-scale

 0.479

High

1149265

 DERL2
Derlin-2

1

1

Small-scale

 0.479

High

1149266

 SE1L1
Protein sel-1 homolog 1

1

1

Small-scale

 0.479

High

618383

 TSN8
Tetraspanin-8

1

0

Small-scale

 0.458

High

1149259

 SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

Small-scale

 0.458

High

Service provided by Combinatics, Japan

Last updated: 11Aug2025