HitPredict

Interactor 1: SIGIR (Q6IA17)
Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
Gene: SIGIRR

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	12925853, 15866876
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 410 Hs			1 522
+	Hs
		1342787 IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		965965 ILRL1_HUMAN (9-320): 1.43e-83: 267: 22.94		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		540406 IL1R1_HUMAN (9-337): 3.46e-82: 264: 20.46		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1344384 TLR9_HUMAN (107-324): 1.02e-52: 191: 23.21		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		179972 TLR3_HUMAN (83-313): 2.3e-49: 181: 16.19		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		120189 TLR4_HUMAN (140-316): 1.42e-46: 173: 24.86		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		936278 TLR9_MOUSE (107-318): 7.19e-52: 188: 20.83		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Mm
		936285 TLR4_MOUSE (136-315): 3.48e-47: 174: 23.91		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Mm
		936274 TLR3_MOUSE (104-313): 4.56e-45: 168: 18.98		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1024765 IL1AP_HUMAN (8-326): 9.29e-90: 283: 23.31		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1306794 MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		607543 MYD88_MOUSE (164-307): 6.09e-13: 70.9: 23.45		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1024770 TLR9_HUMAN (107-324): 1.02e-52: 191: 23.21		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		179933 TLR3_HUMAN (83-313): 2.3e-49: 181: 16.19		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		120151 TLR4_HUMAN (140-316): 1.42e-46: 173: 24.86		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Mm
		1141445 TLR4_MOUSE (136-315): 3.48e-47: 174: 23.91		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Hs
		237506 TLR2_HUMAN (94-307): 3.42e-63: 218: 19.47		TRI58_HUMAN (62-403): 4.42e-43: 161: 11.67
+	Hs
		1024747 MYD88_HUMAN (165-307): 3e-13: 71.7: 22.92		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Mm
		607554 MYD88_MOUSE (164-307): 6.09e-13: 70.9: 23.45		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Hs
		1290202 ILRL2_HUMAN (2-335): 6.67e-73: 240: 21.21		RN125_HUMAN (62-193): 1.59e-11: 66: 25.83