Protein: TF2B
Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)

Gene: TF2B, GTF2B
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q00403

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0000993 - RNA polymerase II complex binding
GO:0001174 - transcriptional start site selection at RNA polymerase II promoter
GO:0004402 - histone acetyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

589827

TBP
TATA-box-binding protein

8

13

Small-scale

0.964

High

624865

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

5

Small-scale

0.866

High

913891

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

4

High-throughput

0.811

High

664011

T2EA
General transcription factor IIE subunit 1

2

1

Small-scale

0.806

High

959934

TNIP1
TNFAIP3-interacting protein 1

4

3

High-throughput

0.698

High

722597

T2FA
General transcription factor IIF subunit 1

4

2

Small-scale

0.696

High

676863

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.691

High

864942

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

3

High-throughput

0.691

High

583692

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

2

Small-scale

0.681

High

959932

NC2A
Dr1-associated corepressor

3

2

High-throughput

0.675

High

854411

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

5

Small-scale

0.656

High

959963

CBP
CREB-binding protein

3

8

Small-scale

0.651

High

913420

TBPL1
TATA box-binding protein-like 1

1

13

Small-scale

0.647

High

583461

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

7

Small-scale

0.628

High

897504

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

3

High-throughput

0.628

High

959941

TAF9
Transcription initiation factor TFIID subunit 9

2

2

Small-scale

0.618

High

156017

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

Small-scale

0.618

High

490096

COT1
COUP transcription factor 1

2

2

Small-scale

0.613

High

854293

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

3

High-throughput

0.611

High

344852

CYTS
Cystatin-S

3

2

High-throughput

0.609

High

344967

CYTN
Cystatin-SN

3

2

High-throughput

0.609

High

448440

CYTT
Cystatin-SA

3

2

High-throughput

0.609

High

959956

MUC7
Mucin-7

3

2

High-throughput

0.609

High

534098

T2FB
General transcription factor IIF subunit 2

2

1

Small-scale

0.602

High

959914

TF65
Transcription factor p65

2

1

Small-scale

0.602

High

959979

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.602

High

381054

PRP1
Basic salivary proline-rich protein 1

3

2

High-throughput

0.599

High

664067

T2EB
Transcription initiation factor IIE subunit beta

2

1

Small-scale

0.595

High

959926

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

Small-scale

0.585

High

612975

TCEA1
Transcription elongation factor A protein 1

2

3

Small-scale

0.585

High

592204

RAB5A
Ras-related protein Rab-5A

2

3

High-throughput

0.571

High

959981

OXSM
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

2

2

High-throughput

0.558

High

62291

GG6L9
Golgin subfamily A member 6-like protein 9

2

1

High-throughput

0.553

High

959937

TAF11
Transcription initiation factor TFIID subunit 11

1

1

Small-scale

0.550

High

959962

TF2H4
General transcription factor IIH subunit 4

1

1

Small-scale

0.550

High

181411

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

High-throughput

0.536

High

225369

MED14
Mediator of RNA polymerase II transcription subunit 14

1

5

High-throughput

0.536

High

649463

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

738842

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

6

High-throughput

0.536

High

959917

EP300
Histone acetyltransferase p300

1

8

Small-scale

0.527

High

429017

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

177488

NVL
Nuclear valosin-containing protein-like

1

4

High-throughput

0.515

High

271071

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

3

High-throughput

0.515

High

346534

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.515

High

822241

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.515

High

914925

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.515

High

959921

CBLB
E3 ubiquitin-protein ligase CBL-B

1

3

High-throughput

0.515

High

959930

LPIN1
Phosphatidate phosphatase LPIN1

1

1

High-throughput

0.515

High

959931

CBX2
Chromobox protein homolog 2

1

1

High-throughput

0.515

High

959948

DCAF8
DDB1- and CUL4-associated factor 8

1

2

High-throughput

0.515

High

959950

TRM1L
TRMT1-like protein

1

1

High-throughput

0.515

High

959954

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

1

High-throughput

0.515

High

959961

JADE3
Protein Jade-3

1

1

High-throughput

0.515

High

959985

KLF15
Krueppel-like factor 15

1

4

High-throughput

0.515

High

48652

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.513

High

571112

EGLN
Endoglin

1

0

High-throughput

0.513

High

959972

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.513

High

959980

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.513

High

959982

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

354054

IGHA1
Immunoglobulin heavy constant alpha 1

2

3

High-throughput

0.504

High

261470

NCOR1
Nuclear receptor corepressor 1

1

4

Small-scale

0.501

High

369412

ESR1
Estrogen receptor

1

2

Small-scale

0.501

High

500409

THA
Thyroid hormone receptor alpha

1

3

Small-scale

0.501

High

595668

BCL3
B-cell lymphoma 3 protein

1

1

Small-scale

0.501

High

782519

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

959913

HSF1
Heat shock factor protein 1

1

3

Small-scale

0.501

High

959915

REL
Proto-oncogene c-Rel

1

1

Small-scale

0.501

High

959920

REST
RE1-silencing transcription factor

1

1

Small-scale

0.501

High

959923

STF1
Steroidogenic factor 1

1

3

Small-scale

0.501

High

959924

CTBP1
C-terminal-binding protein 1

1

2

Small-scale

0.501

High

959928

KLF5
Krueppel-like factor 5

1

3

Small-scale

0.501

High

959933

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

3

Small-scale

0.501

High

173275

S22A2
Solute carrier family 22 member 2

1

3

High-throughput

0.494

High

729213

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

6

High-throughput

0.494

High

235802

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.493

High

265186

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

885441

VSX2
Visual system homeobox 2

1

0

High-throughput

0.493

High

893536

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.493

High

959919

RED
Protein Red

1

0

High-throughput

0.493

High

959947

PHF19
PHD finger protein 19

1

0

High-throughput

0.493

High

959949

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.493

High

959953

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

959955

SPT22
Spermatogenesis-associated protein 22

1

0

High-throughput

0.493

High

959957

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.493

High

959959

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.493

High

959966

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

959969

RPP25
Ribonuclease P protein subunit p25

1

0

High-throughput

0.493

High

959970

RUSC1
AP-4 complex accessory subunit RUSC1

1

0

High-throughput

0.493

High

959971

PBX4
Pre-B-cell leukemia transcription factor 4

1

0

High-throughput

0.493

High

959975

HES4
Transcription factor HES-4

1

0

High-throughput

0.493

High

401853

JUN
Transcription factor Jun

1

0

Small-scale

0.480

High

579254

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.480

High

590570

PO3F2
POU domain, class 3, transcription factor 2

1

0

Small-scale

0.480

High

702481

C2TA
MHC class II transactivator

1

0

Small-scale

0.480

High

848013

MECP2
Methyl-CpG-binding protein 2

1

0

Small-scale

0.480

High

959918

FOXF2
Forkhead box protein F2

1

0

Small-scale

0.480

High

959925

IKZF1
DNA-binding protein Ikaros

1

0

Small-scale

0.480

High

959927

NCOA4
Nuclear receptor coactivator 4

1

0

Small-scale

0.480

High

959939

NCOA1
Nuclear receptor coactivator 1

1

0

Small-scale

0.480

High

959958

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

959977

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

125381

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

244290

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

296897

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.479

High

381928

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

Small-scale

0.479

High

446590

SNRPA
U1 small nuclear ribonucleoprotein A

1

6

Small-scale

0.479

High

501031

IRF1
Interferon regulatory factor 1

1

2

Small-scale

0.479

High

536505

IRF2
Interferon regulatory factor 2

1

2

Small-scale

0.479

High

552506

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

637852

PSA3
Proteasome subunit alpha type-3

1

3

Small-scale

0.479

High

650971

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

668600

PML
Protein PML

1

1

High-throughput

0.479

High

730239

PRS7
26S proteasome regulatory subunit 7

1

2

Small-scale

0.479

High

908381

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

909446

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

918293

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

959916

DHX9
ATP-dependent RNA helicase A

1

4

Small-scale

0.479

High

959922

TIF1B
Transcription intermediary factor 1-beta

1

1

Small-scale

0.479

High

959929

IRF3
Interferon regulatory factor 3

1

2

Small-scale

0.479

High

959935

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

959938

MED1
Mediator of RNA polymerase II transcription subunit 1

1

3

Small-scale

0.479

High

959968

PKP2
Plakophilin-2

1

1

Small-scale

0.479

High

959976

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

High-throughput

0.479

High

959978

MLXPL
Carbohydrate-responsive element-binding protein

1

2

Small-scale

0.479

High

959983

NXF1
Nuclear RNA export factor 1

1

1

Small-scale

0.479

High

959986

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.479

High

208560

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.470

High

394543

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.470

High

720241

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

959942

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.458

High

959951

MKX
Homeobox protein Mohawk

1

0

Small-scale

0.458

High

959960

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

959984

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

233752

NDK8
Putative nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

496858

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

438936

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

4

Small-scale

0.437

High

959973

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

959945

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

159565

ML12B
Myosin regulatory light chain 12B

1

1

Small-scale

0.407

High

365355

PRB2
Basic salivary proline-rich protein 2

1

1

High-throughput

0.407

High

728469

MYH11
Myosin-11

1

1

Small-scale

0.407

High

435043

SP1
Transcription factor Sp1

1

1

Small-scale

0.381

High

632692

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.381

High

353401

PIGR
Polymeric immunoglobulin receptor

3

0

High-throughput

0.347

High

675637

ILEU
Leukocyte elastase inhibitor

3

0

High-throughput

0.347

High

959965

PAUF
Pancreatic adenocarcinoma up-regulated factor

3

0

High-throughput

0.347

High

353114

IGJ
Immunoglobulin J chain

2

0

High-throughput

0.328

High

484814

AMY1B
Alpha-amylase 1B

2

0

High-throughput

0.288

High

854171

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.282

High

959967

DEPD7
DEP domain-containing protein 7

1

0

High-throughput

0.282

High

485165

ZSC22
Zinc finger and SCAN domain-containing protein 22

1

0

High-throughput

0.268

Low

533972

ANXA8
Annexin A8

1

0

High-throughput

0.268

Low

959936

MLC1
Membrane protein MLC1

1

0

High-throughput

0.268

Low

959943

FA98C
Protein FAM98C

1

0

High-throughput

0.268

Low

959944

ZN829
Zinc finger protein 829

1

0

High-throughput

0.268

Low

959952

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

959964

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

959974

CN093
Uncharacterized protein C14orf93

1

0

High-throughput

0.268

Low

352876

IFNB
Interferon beta

1

0

Small-scale

0.249

Low

959940

B2LA1
Bcl-2-related protein A1

1

0

Small-scale

0.249

Low

353514

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.232

Low

581678

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

959946

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024