HitPredict

Interactor 1: PKHA7 (Q6IQ23)
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)
Gene: PLEKHA7

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28877994
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	GO:0044331 - cell-cell adhesion mediated by cadherin GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1121 Hs			1 639
+	Hs
		253366 PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		924640 PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		1153260 PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		235528 PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Hs
		1285194 PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		253410 PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		209019 AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Dm
		1278820 Q95R37_DROME (151-464): 6.25e-52: 186: 19.44		Q9VA36_DROME (4-395): 1.02e-46: 179: 26.40
+	Hs
		253330 AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		125051 WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		876349 AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		125348 WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924812 CYH2_HUMAN (105-300): 1.31e-44: 168: 21.50		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		298964 AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Hs
		876420 AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Ce
		1341509 WWP1_CAEEL (3-204): 1.94e-50: 194: 23.59		Q9U2T9_CAEEL (27-492): 3.56e-11: 68.5: 13.89
+	Hs
		235492 AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Mm
		1194490 CNKR2_MOUSE (119-516): 8.05e-46: 181: 17.87		ARHG7_MOUSE (230-378): 9.82e-13: 73.4: 26.17
+	Hs
		125507 WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Hs
		1074101 CYH1_HUMAN (105-281): 4.55e-43: 164: 21.69		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64