HitPredict

Interactor 1: NEDD8 (Q15843)
Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)
Gene: NEDD8

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	30659753
Identification Methods	unspecified method, pull down, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, ubiquitin~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 589
+	Hs
		987268 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		UBQL1_HUMAN (1-589): 1.24e-174: 509: 100.00
+	Hs
		987499 RL40_HUMAN (1-76): 3.81e-33: 112: 57.90		UBQL1_HUMAN (1-589): 1.24e-174: 509: 100.00
+	Hs
		1385479 Q96C32_HUMAN (1-76): 2.04e-29: 107: 57.90		UBQL1_HUMAN (1-589): 1.24e-174: 509: 100.00
+	Hs
		987259 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		UBQL2_HUMAN (1-589): 9.56e-145: 433: 71.29
+	Hs
		987494 RL40_HUMAN (1-76): 3.81e-33: 112: 57.90		UBQL2_HUMAN (1-589): 9.56e-145: 433: 71.29
+	Dm
		583716 RS27A_DROME (1-77): 3.4e-36: 121: 57.14		Q9VWD9_DROME (30-582): 3.33e-135: 407: 47.39
+	Ce
		113201 RL40_CAEEL (1-76): 3.87e-32: 109: 56.58		UBQL_CAEEL (31-586): 1.67e-115: 354: 36.30
+	Zm
		23042 A0A1D6I4G6_MAIZE (2-76): 8.51e-33: 113: 84.00		C0PFA7_MAIZE (44-586): 6.19e-109: 339: 29.29
+	Dm
		583719 RS27A_DROME (1-77): 3.4e-36: 121: 57.14		Q9VXF9_DROME (37-317): 4.1e-51: 184: 17.93
+	Dm
		1478106 NEDD8_DROME (1-76): 2.22e-34: 113: 93.42		Q9VXF9_DROME (37-317): 4.1e-51: 184: 17.93
+	Dm
		583697 RS27A_DROME (1-77): 3.4e-36: 121: 57.14		Q9V3W9_DROME (37-394): 1.43e-40: 154: 13.95
+	Hs
		986976 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		RL40_HUMAN (37-126): 1.89e-34: 128: 30.77
+	Dm
		583653 RS27A_DROME (1-77): 3.4e-36: 121: 57.14		RL40_DROME (37-126): 7.86e-34: 126: 29.67
+	Mm
		987305 RL40_MOUSE (1-76): 3.81e-33: 112: 57.90		RL40_MOUSE (37-126): 1.89e-34: 128: 30.77
+	Hs
		987318 RL40_HUMAN (1-76): 3.81e-33: 112: 57.90		RL40_HUMAN (37-126): 1.89e-34: 128: 30.77
+	Sc
		509884 RL40A_YEAST (1-76): 1.88e-32: 110: 55.26		RAD23_YEAST (45-419): 1.18e-31: 128: 17.73
+	Hs
		986975 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		RS27A_HUMAN (37-123): 1.11e-12: 68: 30.68
+	Bt
		987512 RS27A_BOVIN (1-77): 6.68e-37: 122: 57.14		RS27A_BOVIN (37-123): 1.11e-12: 68: 30.68