HitPredict

Interactor 1: KLC3 (Q6P597)
Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)
Gene: KLC3

Interactor 2: KLC2 (Q9H0B6)
Kinesin light chain 2 (KLC 2)
Gene: KLC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	26496610, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TPR_10~TPR_12, TPR_12~TPR_12
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005871 - kinesin complex GO:0005874 - microtubule GO:0007018 - microtubule-based movement and 1 others more... GO:0019894 - kinesin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 622
+	Hs
		1160007 KLC3_HUMAN (1-504): 1.73e-94: 297: 100.00		KLC4_HUMAN (7-618): 1.11e-105: 334: 69.13
+	Hs
		102444 KLC2_HUMAN (15-499): 1.5e-87: 283: 56.17		G3V5R9_HUMAN (1-614): 5.14e-107: 337: 66.35
+	Hs
		1327445 KLC2_HUMAN (15-499): 1.5e-87: 283: 56.17		KLC4_HUMAN (7-618): 1.11e-105: 334: 69.13
+	Hs
		103891 KLC3_HUMAN (1-504): 1.73e-94: 297: 100.00		G5E9S8_HUMAN (1-503): 8.47e-92: 295: 71.79
+	Hs
		102445 KLC4_HUMAN (2-466): 5.1e-30: 125: 21.63		G3V5R9_HUMAN (1-614): 5.14e-107: 337: 66.35
+	Mm
		1131617 CLU_MOUSE (21-497): 9.09e-62: 221: 16.67		CLU_MOUSE (192-544): 2.64e-56: 208: 19.06
+	Hs
		256605 CLU_HUMAN (21-503): 2.71e-46: 175: 16.07		CLU_HUMAN (192-531): 2.39e-56: 208: 17.48
+	Hs
		1159970 KLC3_HUMAN (1-504): 1.73e-94: 297: 100.00		KLC3_HUMAN (363-616): 1.47e-16: 84.7: 21.78
+	Hs
		175003 NPHP3_HUMAN (64-504): 6.32e-45: 171: 21.97		OGT1_HUMAN (58-526): 3.14e-51: 192: 16.63
+	Hs
		992351 KLC3_HUMAN (1-504): 1.73e-94: 297: 100.00		KLC1_HUMAN (406-586): 8.56e-10: 63.5: 12.50
+	Mm
		291534 KLC2_MOUSE (15-499): 8.43e-80: 262: 56.58		KLC1_MOUSE (312-512): 9.12e-21: 98.2: 21.43
+	Ce
		807892 KLC_CAEEL (17-501): 9.29e-75: 247: 46.09		KLC_CAEEL (312-620): 1.61e-24: 109: 17.35
+	Hs
		992391 KLC2_HUMAN (15-499): 1.5e-87: 283: 56.17		KLC1_HUMAN (406-586): 8.56e-10: 63.5: 12.50
+	Dm
		54979 CLU_DROME (21-461): 5.35e-58: 210: 15.68		CLU_DROME (209-458): 4.79e-26: 116: 21.79
+	Dm
		115869 M9PGT5_DROME (86-443): 2.98e-55: 198: 20.74		KLC_DROME (268-594): 1.89e-28: 121: 26.06
+	Dm
		807907 KLC_DROME (2-434): 1.28e-26: 114: 22.60		KLC_DROME (268-594): 1.89e-28: 121: 26.06
+	Hs
		992396 KLC4_HUMAN (2-466): 5.1e-30: 125: 21.63		KLC1_HUMAN (406-586): 8.56e-10: 63.5: 12.50