HitPredict

Interactor 1: TRI65 (Q6PJ69)
E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65)
Gene: TRIM65

Interactor 2: NLRP3 (Q96P20)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34512673
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050728 - negative regulation of inflammatory response
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 517 Hs			1 1036
+	Mm
		1112452 Q3UCL2_MOUSE (1-503): 2.9e-123: 370: 20.62		NLRP3_MOUSE (3-1036): 0: 848: 82.72
+	Mm
		1206333 TRI65_MOUSE (1-514): 2.64e-112: 344: 64.41		NLRP3_MOUSE (3-1036): 0: 848: 82.72
+	Hs
		1204904 TRI50_HUMAN (1-496): 3.3e-98: 307: 20.08		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Hs
		183332 MEFV_HUMAN (42-506): 1.55e-84: 279: 15.96		NLRP3_HUMAN (1-1036): 0: 881: 100.00
+	Mm
		1194997 TRI50_MOUSE (4-510): 1.24e-97: 305: 18.69		NLRP3_MOUSE (3-1036): 0: 848: 82.72
+	Mm
		1207374 TRI14_MOUSE (74-503): 1.54e-93: 293: 23.98		NLRP3_MOUSE (3-1036): 0: 848: 82.72
+	Mm
		1246775 TRI31_MOUSE (5-491): 4.77e-89: 284: 19.24		NLRP3_MOUSE (3-1036): 0: 848: 82.72
+	Hs
		1162057 TRI65_HUMAN (1-517): 3.11e-124: 375: 100.00		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		886400 TRI25_HUMAN (6-503): 8.9e-99: 312: 22.58		NAL12_HUMAN (788-1036): 1.62e-36: 151: 39.76
+	Hs
		1149907 TRI68_HUMAN (4-506): 1.89e-113: 346: 19.08		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		537077 TRI27_HUMAN (3-510): 6.09e-122: 369: 20.77		NOD2_HUMAN (838-1032): 4.59e-12: 72.4: 25.13
+	Hs
		1162063 TRI65_HUMAN (1-517): 3.11e-124: 375: 100.00		NLRC4_HUMAN (826-1031): 5.33e-09: 62.4: 20.48
+	Hs
		135016 TRI38_HUMAN (2-502): 1.06e-103: 320: 19.84		NLRP6_HUMAN (821-1034): 5.64e-19: 94.8: 21.95
+	Hs
		1052765 TRI25_HUMAN (6-503): 8.9e-99: 312: 22.58		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		1223391 TRI22_HUMAN (5-502): 3.47e-107: 330: 18.80		NOD2_HUMAN (838-1032): 4.59e-12: 72.4: 25.13
+	Hs
		702498 TRI22_HUMAN (5-502): 3.47e-107: 330: 18.80		C2TA_HUMAN (886-1031): 2.1e-11: 70.5: 23.84
+	Hs
		183335 MEFV_HUMAN (42-506): 1.55e-84: 279: 15.96		NLRP1_HUMAN (897-1031): 5.84e-21: 101: 35.56
+	Hs
		1204907 TRI50_HUMAN (1-496): 3.3e-98: 307: 20.08		NOD2_HUMAN (838-1032): 4.59e-12: 72.4: 25.13
+	Hs
		183339 MEFV_HUMAN (42-506): 1.55e-84: 279: 15.96		NALP2_HUMAN (844-1029): 8.96e-14: 78.2: 31.18