HitPredict

Interactor 1: TRAF7 (Q6Q0C0)
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
Gene: TRAF7

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.50	0.654

Property	Details
Experiments	14743216, 32707033, 36736316, 37043537, 15001576
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 670 Hs			1 626
+	Hs
		1163055 TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		1377156 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Dm
		1213409 NLE_DROME (379-669): 1.1e-71: 242: 21.20		AKT1_DROME (102-622): 4.6e-128: 392: 20.60
+	Dm
		218248 O44382_DROME (181-591): 3.08e-62: 217: 14.77		AKT1_DROME (102-622): 4.6e-128: 392: 20.60
+	Dm
		1213390 Q9VDE3_DROME (181-591): 1.74e-61: 215: 14.77		AKT1_DROME (102-622): 4.6e-128: 392: 20.60
+	Mm
		661011 FBXW7_MOUSE (70-499): 1.9e-45: 174: 12.81		KPCD_MOUSE (22-625): 1.02e-139: 424: 17.59
+	Hs
		682082 FBW1A_HUMAN (175-586): 2.32e-60: 214: 15.99		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		681967 FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67