Protein: H2B1L
Histone H2B type 1-L (Histone H2B.c) (H2B/c)

Gene: H2B1L, H2BC13
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q99880

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1381852

H2B1A
Histone H2B type 1-A

5

20

High-throughput

0.922

High

998738

H31
Histone H3.1

5

20

High-throughput

0.906

High

1323968

H2B3B
Histone H2B type 3-B

4

19

High-throughput

0.886

High

980216

H4
Histone H4

4

20

High-throughput

0.881

High

256971

H2B1K
Histone H2B type 1-K

4

20

High-throughput

0.873

High

1258928

H32
Histone H3.2

4

20

High-throughput

0.873

High

1163170

H2B2E
Histone H2B type 2-E

3

20

High-throughput

0.847

High

419168

H2A1B
Histone H2A type 1-B/E

3

20

High-throughput

0.839

High

1162021

H31T
Histone H3.1t

3

20

High-throughput

0.839

High

946868

H2B1D
Histone H2B type 1-D

3

20

High-throughput

0.827

High

1272818

H2A3
Histone H2A type 3

3

20

High-throughput

0.827

High

449780

H2B1J
Histone H2B type 1-J

2

20

High-throughput

0.754

High

502500

H2A1
Histone H2A type 1

2

20

High-throughput

0.754

High

591813

H2AX
Histone H2AX

2

20

High-throughput

0.754

High

634061

H2A1D
Histone H2A type 1-D

2

20

High-throughput

0.754

High

659939

H2B1O
Histone H2B type 1-O

2

20

High-throughput

0.754

High

943412

H2BFS
Histone H2B type F-S

2

19

High-throughput

0.754

High

981048

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

987176

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

20

High-throughput

0.754

High

987462

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

20

High-throughput

0.754

High

1017160

H33
Histone H3.3

2

20

High-throughput

0.754

High

1208882

H2B2F
Histone H2B type 2-F

2

20

High-throughput

0.754

High

1232723

H2A2A
Histone H2A type 2-A

2

20

High-throughput

0.754

High

1372240

H2A1C
Histone H2A type 1-C

2

20

High-throughput

0.754

High

1372285

H2B1H
Histone H2B type 1-H

2

19

High-throughput

0.754

High

1407989

H2B1N
Histone H2B type 1-N

2

20

High-throughput

0.754

High

1408045

H2AJ
Histone H2A.J

2

20

High-throughput

0.754

High

372965

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.691

High

1291161

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.691

High

1408059

KTU
Protein kintoun

3

2

High-throughput

0.667

High

1278692

KI21A
Kinesin-like protein KIF21A

1

11

High-throughput

0.665

High

1164232

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.638

High

1408060

ARMC1
Armadillo repeat-containing protein 1

3

0

High-throughput

0.638

High

1408065

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

129369

MEN1
Menin

1

3

High-throughput

0.618

High

190163

TNC18
Trinucleotide repeat-containing gene 18 protein

1

20

High-throughput

0.618

High

502107

H2AZ
Histone H2A.Z

1

20

High-throughput

0.618

High

507340

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

508513

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

595574

H15
Histone H1.5

1

20

High-throughput

0.618

High

595857

H13
Histone H1.3

1

20

High-throughput

0.618

High

754965

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

855509

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.618

High

888284

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.618

High

1041588

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.618

High

1132929

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

1153218

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

11

High-throughput

0.618

High

1162882

H2A2C
Histone H2A type 2-C

1

20

High-throughput

0.618

High

1239471

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

1259632

H2AV
Histone H2A.V

1

20

High-throughput

0.618

High

1352713

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.618

High

1368086

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.618

High

1380582

IGSF8
Immunoglobulin superfamily member 8

1

20

High-throughput

0.618

High

1399491

IPO9
Importin-9

1

14

High-throughput

0.618

High

1408028

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.618

High

1408056

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.618

High

1408062

HDAC6
Protein deacetylase HDAC6

1

18

Small-scale

0.618

High

1408063

DAXX
Death domain-associated protein 6

1

3

Small-scale

0.618

High

1408066

BAZ1B
Tyrosine-protein kinase BAZ1B

1

20

High-throughput

0.618

High

187168

PPM1G
Protein phosphatase 1G

2

11

High-throughput

0.611

High

542629

TOP2A
DNA topoisomerase 2-alpha

2

14

High-throughput

0.611

High

601832

HMGA1
High mobility group protein HMG-I/HMG-Y

2

15

High-throughput

0.611

High

1112683

CUL1
Cullin-1

2

10

Small-scale

0.611

High

504960

H2AB2
Histone H2A-Bbd type 2/3

2

20

High-throughput

0.606

High

1386679

AP2M1
AP-2 complex subunit mu

2

2

High-throughput

0.606

High

1408043

JPH2
Junctophilin-2

2

9

High-throughput

0.601

High

157778

CTRO
Citron Rho-interacting kinase

2

17

High-throughput

0.584

High

426565

HMGN2
Non-histone chromosomal protein HMG-17

2

20

High-throughput

0.584

High

1151433

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

2

14

High-throughput

0.584

High

1194325

LARP7
La-related protein 7

2

20

High-throughput

0.584

High

1405082

H4G
Histone H4-like protein type G

2

20

High-throughput

0.584

High

249776

DOK2
Docking protein 2

2

8

High-throughput

0.571

High

396804

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

436722

KPCB
Protein kinase C beta type

2

20

High-throughput

0.571

High

440190

LCK
Tyrosine-protein kinase Lck

2

6

High-throughput

0.571

High

702371

ELK4
ETS domain-containing protein Elk-4

2

12

High-throughput

0.571

High

987896

GRB2
Growth factor receptor-bound protein 2

2

18

High-throughput

0.571

High

1097160

MK07
Mitogen-activated protein kinase 7

2

11

High-throughput

0.571

High

1027696

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

8

High-throughput

0.536

High

1392820

TONSL
Tonsoku-like protein

1

11

Small-scale

0.536

High

1403102

OSBL9
Oxysterol-binding protein-related protein 9

1

6

High-throughput

0.536

High

1408073

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

16

High-throughput

0.536

High

1206959

CEP78
Centrosomal protein of 78 kDa

1

3

High-throughput

0.515

High

1394960

ZN469
Zinc finger protein 469

1

2

High-throughput

0.515

High

1400786

ATAD5
ATPase family AAA domain-containing protein 5

1

20

High-throughput

0.515

High

1408061

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.515

High

1408064

DPOLL
DNA polymerase lambda

1

4

High-throughput

0.515

High

1408067

NUP50
Nuclear pore complex protein Nup50

1

5

High-throughput

0.515

High

1408068

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

High-throughput

0.515

High

906922

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

822835

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.501

High

955522

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

854917

RECQ1
ATP-dependent DNA helicase Q1

1

9

Small-scale

0.500

High

71466

P20L1
PHD finger protein 20-like protein 1

1

4

High-throughput

0.479

High

137477

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

20

High-throughput

0.479

High

138290

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

13

High-throughput

0.479

High

175764

SR140
U2 snRNP-associated SURP motif-containing protein

1

3

High-throughput

0.479

High

192849

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

3

High-throughput

0.479

High

223284

PRC1
Protein regulator of cytokinesis 1

1

9

High-throughput

0.479

High

226868

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

8

High-throughput

0.479

High

227651

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.479

High

302203

NEBL
Nebulette

1

20

High-throughput

0.479

High

318052

TOM70
Mitochondrial import receptor subunit TOM70

1

10

High-throughput

0.479

High

325077

HEXI1
Protein HEXIM1

1

14

High-throughput

0.479

High

331263

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

386152

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.479

High

414501

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

424454

HMGN1
Non-histone chromosomal protein HMG-14

1

8

High-throughput

0.479

High

427933

ICAM1
Intercellular adhesion molecule 1

1

20

High-throughput

0.479

High

431232

LA
Lupus La protein

1

20

High-throughput

0.479

High

447358

NPM
Nucleophosmin

1

5

High-throughput

0.479

High

460623

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

8

High-throughput

0.479

High

468736

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

539571

PYGB
Glycogen phosphorylase, brain form

1

1

High-throughput

0.479

High

548589

MPRI
Cation-independent mannose-6-phosphate receptor

1

4

High-throughput

0.479

High

565460

ITA4
Integrin alpha-4

1

7

High-throughput

0.479

High

571688

HCLS1
Hematopoietic lineage cell-specific protein

1

20

High-throughput

0.479

High

607049

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

620546

NUCL
Nucleolin

1

6

High-throughput

0.479

High

630013

BTF3
Transcription factor BTF3

1

11

High-throughput

0.479

High

650928

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

17

High-throughput

0.479

High

660714

IF4B
Eukaryotic translation initiation factor 4B

1

12

High-throughput

0.479

High

667427

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

9

High-throughput

0.479

High

675650

TYY1
Transcriptional repressor protein YY1

1

12

High-throughput

0.479

High

681496

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

698360

MAP4
Microtubule-associated protein 4

1

20

High-throughput

0.479

High

756034

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

773260

MYH10
Myosin-10

1

11

High-throughput

0.479

High

775748

CYLC1
Cylicin-1

1

20

High-throughput

0.479

High

824310

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

854256

KI67
Proliferation marker protein Ki-67

1

20

High-throughput

0.479

High

859041

RL27A
Large ribosomal subunit protein uL15

1

2

High-throughput

0.479

High

859417

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

861266

MAP1B
Microtubule-associated protein 1B

1

20

High-throughput

0.479

High

867821

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

7

High-throughput

0.479

High

897373

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.479

High

897953

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.479

High

915480

HMGA2
High mobility group protein HMGI-C

1

2

Small-scale

0.479

High

948918

CD81
CD81 antigen

1

11

High-throughput

0.479

High

966799

1433G
14-3-3 protein gamma

1

12

High-throughput

0.479

High

973554

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.479

High

975892

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.479

High

981665

RAN
GTP-binding nuclear protein Ran

1

6

High-throughput

0.479

High

993474

SPT4H
Transcription elongation factor SPT4

1

2

High-throughput

0.479

High

1004391

NOP14
Nucleolar protein 14

1

4

High-throughput

0.479

High

1008855

RED1
Double-stranded RNA-specific editase 1

1

14

High-throughput

0.479

High

1040364

DYST
Dystonin

1

11

High-throughput

0.479

High

1043736

CEBPZ
CCAAT/enhancer-binding protein zeta

1

3

High-throughput

0.479

High

1049711

1433F
14-3-3 protein eta

1

12

High-throughput

0.479

High

1103342

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.479

High

1105079

TCOF
Treacle protein

1

20

High-throughput

0.479

High

1119879

CKAP5
Cytoskeleton-associated protein 5

1

8

High-throughput

0.479

High

1120309

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

19

Small-scale

0.479

High

1134521

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

20

High-throughput

0.479

High

1138555

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1140749

KIF14
Kinesin-like protein KIF14

1

16

High-throughput

0.479

High

1161620

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1211613

TEX35
Testis-expressed protein 35

1

12

High-throughput

0.479

High

1213318

RM02
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.479

High

1217499

CE350
Centrosome-associated protein 350

1

10

High-throughput

0.479

High

1226798

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

3

High-throughput

0.479

High

1271817

MEPCE
7SK snRNA methylphosphate capping enzyme

1

14

High-throughput

0.479

High

1281379

DPPA2
Developmental pluripotency-associated protein 2

1

10

High-throughput

0.479

High

1281597

SLN11
Schlafen family member 11

1

3

High-throughput

0.479

High

1289577

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1313375

SMC5
Structural maintenance of chromosomes protein 5

1

14

High-throughput

0.479

High

1334830

SERB1
SERPINE1 mRNA-binding protein 1

1

12

High-throughput

0.479

High

1361902

TITIN
Titin

1

19

High-throughput

0.479

High

1369251

JARD2
Protein Jumonji

1

11

High-throughput

0.479

High

1370693

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

1397358

CI072
Guanine nucleotide exchange factor C9orf72

1

6

High-throughput

0.479

High

1408044

RIOK1
Serine/threonine-protein kinase RIO1

1

12

High-throughput

0.479

High

1408046

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

10

High-throughput

0.479

High

1408047

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.479

High

1408048

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

1408049

ACE2
Angiotensin-converting enzyme 2

1

4

High-throughput

0.479

High

1408050

SPRTN
DNA-dependent metalloprotease SPRTN

1

8

Small-scale

0.479

High

1408053

SFR19
Splicing factor, arginine/serine-rich 19

1

20

High-throughput

0.479

High

1408054

SHCAF
SIN3-HDAC complex-associated factor

1

1

Small-scale

0.479

High

1408055

ENY2
Transcription and mRNA export factor ENY2

1

4

High-throughput

0.479

High

1408057

DUOX2
Dual oxidase 2

1

12

High-throughput

0.479

High

1408058

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

20

High-throughput

0.479

High

1408069

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.479

High

1408071

WBP11
WW domain-binding protein 11

1

20

High-throughput

0.479

High

1408072

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.479

High

1408075

PCLO
Protein piccolo

1

20

High-throughput

0.479

High

353528

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

1205179

TM196
Transmembrane protein 196

1

3

High-throughput

0.470

High

1408052

MAGIX
PDZ domain-containing protein MAGIX

1

5

High-throughput

0.470

High

1293807

FBX11
F-box only protein 11

1

0

Small-scale

0.458

High

328127

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

7

High-throughput

0.445

High

619907

VCAM1
Vascular cell adhesion protein 1

1

11

High-throughput

0.445

High

952312

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.445

High

1408051

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

7

High-throughput

0.445

High

125969

SMAP
Small acidic protein

1

4

High-throughput

0.437

High

221649

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

5

High-throughput

0.437

High

412511

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

566816

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.437

High

1051843

EF1A2
Elongation factor 1-alpha 2

1

7

High-throughput

0.437

High

1102317

CD5R2
Cyclin-dependent kinase 5 activator 2

1

12

High-throughput

0.437

High

1168559

KNOP1
Lysine-rich nucleolar protein 1

1

8

High-throughput

0.437

High

1219829

ERI6B
Glutamate-rich protein 6B

1

1

High-throughput

0.437

High

1247557

ZN474
Zinc finger protein 474

1

10

High-throughput

0.437

High

1255247

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

1286764

CROL1
Putative ciliary rootlet coiled-coil protein-like 1 protein

1

3

High-throughput

0.437

High

1324063

RHG24
Rho GTPase-activating protein 24

1

15

High-throughput

0.437

High

1403222

MA7D2
MAP7 domain-containing protein 2

1

20

High-throughput

0.437

High

1408070

TENN
Tenascin-N

1

20

High-throughput

0.437

High

1408074

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

4

High-throughput

0.437

High

87530

OSCRI
SCRIB overlapping open reading frame protein

1

1

High-throughput

0.407

High

124462

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.347

High


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Last updated: 11Aug2025