HitPredict

Interactor 1: PKS12 (I6XD69)
Mycoketide-CoA synthase (EC 2.3.1.295) (Polyketide synthase Pks12)
Gene: PKS12

Interactor 2: PKS12 (I6XD69)
Mycoketide-CoA synthase (EC 2.3.1.295) (Polyketide synthase Pks12)
Gene: PKS12

Species: Mycobacterium tuberculosis H37Rv

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.44 1.00 0.666

The method score is based on:

Property Details
Experiments 18613748
Identification Methods cosedimentation in solution, atomic force microscopy
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Acyl_transf_1~Acyl_transf_1, Acyl_transf_1~KAsynt_C_assoc, Acyl_transf_1~PP-binding, ADH_N~ADH_N, ADH_N~ADH_zinc_N_2, ADH_N~KR, ADH_N~PS-DH, ADH_zinc_N_2~ADH_zinc_N_2, ADH_zinc_N_2~KR, ADH_zinc_N_2~SpnB_Rossmann, KAsynt_C_assoc~KAsynt_C_assoc, KAsynt_C_assoc~ketoacyl-synt, KAsynt_C_assoc~Ketoacyl-synt_C, KAsynt_C_assoc~PP-binding, ketoacyl-synt~ketoacyl-synt, Ketoacyl-synt_C~ketoacyl-synt, KR~ketoacyl-synt, PKS_DH_N~ketoacyl-synt, PP-binding~ketoacyl-synt, PS-DH~ketoacyl-synt and 9 others

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Common GO terms GO:0004312 - fatty acid synthase activity
GO:0004315 - 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0006633 - fatty acid biosynthetic process
GO:0016491 - oxidoreductase activity
GO:0031177 - phosphopantetheine binding
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 4151
Mt

1 4151
+ Rn
+ Ss
+ Bs
+ Hs
+ Ec
+ Mt
+ Ec
+ Sc
+ Pa
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Sc
+ Mt
+ Bs

Service provided by Combinatics, Japan

Last updated: 11Aug2025