HitPredict

Interactor 1: SGK1 (O00141)
Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)
Gene: SGK1

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	12387817, 11751930
Identification Methods	pull down, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 431 Hs			1 337
+	Hs
		566396 KPCA_HUMAN (27-430): 1.24e-144: 429: 37.32		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153882 AKT1_HUMAN (25-426): 4.84e-154: 446: 41.57		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		153871 KPCA_HUMAN (27-430): 1.24e-144: 429: 37.32		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Dm
		397196 KPC1_DROME (27-430): 2.07e-151: 446: 36.98		Q9VX75_DROME (28-333): 2.4e-36: 141: 22.47
+	Dm
		54651 APKC_DROME (6-426): 5.06e-147: 433: 34.03		Q0KHR3_DROME (28-333): 3.13e-36: 141: 22.47
+	Dm
		54668 APKC_DROME (6-426): 5.06e-147: 433: 34.03		Q9VX75_DROME (28-333): 2.4e-36: 141: 22.47
+	Dm
		54675 APKC_DROME (6-426): 5.06e-147: 433: 34.03		X2JFU8_DROME (28-333): 2.24e-36: 141: 22.47
+	Hs
		153900 KS6A3_HUMAN (88-368): 4.35e-106: 331: 28.77		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Dm
		54646 APKC_DROME (6-426): 5.06e-147: 433: 34.03		DLG1_DROME (12-325): 4.79e-25: 108: 16.57
+	Mm
		554913 KPCE_MOUSE (6-423): 2.56e-151: 448: 34.91		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		681891 AKT1_HUMAN (25-426): 4.84e-154: 446: 41.57		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		682200 AKT2_HUMAN (25-426): 1.53e-155: 450: 40.52		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Dm
		54637 APKC_DROME (6-426): 5.06e-147: 433: 34.03		O96782_DROME (14-227): 3.94e-14: 75.3: 18.53
+	Mm
		934625 KPCB_MOUSE (27-430): 1.19e-145: 431: 37.53		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Rn
		404387 KPCA_RAT (27-430): 4.74e-145: 430: 37.32		DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48
+	Hs
		566353 KPCA_HUMAN (27-430): 1.24e-144: 429: 37.32		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		934628 KPCB_MOUSE (27-430): 1.19e-145: 431: 37.53		INADL_MOUSE (8-129): 5.85e-13: 71.9: 21.88
+	Hs
		566388 KPCA_HUMAN (27-430): 1.24e-144: 429: 37.32		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Rn
		404390 KPCA_RAT (27-430): 4.74e-145: 430: 37.32		DLG3_RAT (103-220): 4.99e-09: 59.6: 20.00
+	Mm
		1143553 KS6A2_MOUSE (56-403): 4.48e-109: 339: 28.41		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48