Protein: CERS6
Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)

Gene: CERS6
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q6ZMG9

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005789 - endoplasmic reticulum membrane
GO:0006954 - inflammatory response
GO:0014003 - oligodendrocyte development
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1251752

CERS4
Ceramide synthase 4

1

7

High-throughput

0.691

High

1251721

RETR3
Reticulophagy regulator 3

3

2

High-throughput

0.667

High

1251733

LPAR1
Lysophosphatidic acid receptor 1

3

12

High-throughput

0.667

High

1251748

P2Y12
P2Y purinoceptor 12

3

17

High-throughput

0.667

High

1251750

SG196
Protein O-mannose kinase

3

4

High-throughput

0.667

High

1251718

CERS6
Ceramide synthase 6

1

7

Small-scale

0.647

High

1251735

CERS2
Ceramide synthase 2

1

7

Small-scale

0.647

High

669015

FPR2
N-formyl peptide receptor 2

2

20

High-throughput

0.628

High

1159070

C3AR
C3a anaphylatoxin chemotactic receptor

2

20

High-throughput

0.628

High

604834

HXB9
Homeobox protein Hox-B9

1

4

High-throughput

0.618

High

665622

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

1

High-throughput

0.611

High

702794

5HT2C
5-hydroxytryptamine receptor 2C

3

13

High-throughput

0.604

High

1251755

GPR84
G-protein coupled receptor 84

3

13

High-throughput

0.604

High

443846

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

3

High-throughput

0.601

High

722500

CTR1
High affinity cationic amino acid transporter 1

2

8

High-throughput

0.601

High

832422

OPRX
Nociceptin receptor

2

5

High-throughput

0.591

High

720676

AGTR1
Type-1 angiotensin II receptor

1

19

High-throughput

0.582

High

280233

SC22B
Vesicle-trafficking protein SEC22b

2

0

High-throughput

0.580

High

1251722

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.578

High

466924

ACM4
Muscarinic acetylcholine receptor M4

2

14

High-throughput

0.574

High

835303

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

8

High-throughput

0.574

High

1251741

GPR21
Probable G-protein coupled receptor 21

2

6

High-throughput

0.574

High

1251751

IPPK
Inositol-pentakisphosphate 2-kinase

2

3

High-throughput

0.574

High

1251745

B2L13
Bcl-2-like protein 13

1

1

Small-scale

0.561

High

617536

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

2

1

High-throughput

0.549

High

1154490

STXB2
Syntaxin-binding protein 2

2

2

High-throughput

0.549

High

132612

UPK1A
Uroplakin-1a

1

5

High-throughput

0.536

High

336545

PIGN
GPI ethanolamine phosphate transferase 1

1

1

High-throughput

0.536

High

630166

ACM3
Muscarinic acetylcholine receptor M3

1

13

High-throughput

0.536

High

698793

CALX
Calnexin

1

2

High-throughput

0.536

High

719802

V2R
Vasopressin V2 receptor

1

8

High-throughput

0.536

High

784645

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.536

High

878043

AGRE5
Adhesion G protein-coupled receptor E5

1

4

High-throughput

0.536

High

1053807

KDSR
3-ketodihydrosphingosine reductase

1

3

High-throughput

0.536

High

1251725

AGRG5
Adhesion G-protein coupled receptor G5

1

3

High-throughput

0.536

High

1251726

AGRG2
Adhesion G-protein coupled receptor G2

1

3

High-throughput

0.536

High

1251730

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

1251731

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

1

High-throughput

0.536

High

1251734

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

1251736

BSCL2
Seipin

1

3

High-throughput

0.536

High

1251737

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.536

High

1251740

SEC62
Translocation protein SEC62

1

3

High-throughput

0.536

High

1251742

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

1

High-throughput

0.536

High

1251743

CML1
Chemerin-like receptor 1

1

19

High-throughput

0.536

High

1251749

TTYH1
Protein tweety homolog 1

1

3

High-throughput

0.536

High

1251757

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

3

High-throughput

0.536

High

1251764

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

13

High-throughput

0.536

High

226335

SNG1
Synaptogyrin-1

1

0

High-throughput

0.513

High

851147

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.513

High

922737

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.513

High

947901

T2R19
Taste receptor type 2 member 19

1

0

High-throughput

0.513

High

1251720

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.513

High

1251732

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

0

High-throughput

0.513

High

1251738

TM169
Transmembrane protein 169

1

0

High-throughput

0.513

High

1251744

EFC4B
EF-hand calcium-binding domain-containing protein 4B

1

0

High-throughput

0.513

High

1251747

LMA2L
VIP36-like protein

1

0

High-throughput

0.513

High

1251756

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.513

High

1251766

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.513

High

349457

TSN15
Tetraspanin-15

1

4

High-throughput

0.489

High

351915

S1PR4
Sphingosine 1-phosphate receptor 4

1

15

High-throughput

0.489

High

438893

CD1A
T-cell surface glycoprotein CD1a

1

1

High-throughput

0.489

High

638204

S1PR1
Sphingosine 1-phosphate receptor 1

1

14

High-throughput

0.489

High

723691

NTR1
Neurotensin receptor type 1

1

7

High-throughput

0.489

High

746210

STX2
Syntaxin-2

1

1

High-throughput

0.489

High

771159

APJ
Apelin receptor

1

15

High-throughput

0.489

High

855336

5HT3A
5-hydroxytryptamine receptor 3A

1

1

High-throughput

0.489

High

867636

GPR12
G-protein coupled receptor 12

1

14

High-throughput

0.489

High

868299

P2RY1
P2Y purinoceptor 1

1

15

High-throughput

0.489

High

880164

PTH2R
Parathyroid hormone 2 receptor

1

8

High-throughput

0.489

High

907024

CCR6
C-C chemokine receptor type 6

1

14

High-throughput

0.489

High

940664

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

1

High-throughput

0.489

High

963431

STXB1
Syntaxin-binding protein 1

1

2

High-throughput

0.489

High

1101544

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

15

High-throughput

0.489

High

1157453

PKN1
Serine/threonine-protein kinase N1

1

3

High-throughput

0.489

High

1197801

S39AC
Zinc transporter ZIP12

1

8

High-throughput

0.489

High

1244725

KLD10
Kelch domain-containing protein 10

1

1

High-throughput

0.489

High

1249492

VSTM1
V-set and transmembrane domain-containing protein 1

1

1

High-throughput

0.489

High

1251723

S22A9
Organic anion transporter 7

1

7

High-throughput

0.489

High

1251727

MACOI
Macoilin

1

1

High-throughput

0.489

High

1251746

S22A4
Solute carrier family 22 member 4

1

7

High-throughput

0.489

High

1251753

LPAR2
Lysophosphatidic acid receptor 2

1

14

High-throughput

0.489

High

1251754

GPR35
G-protein coupled receptor 35

1

17

High-throughput

0.489

High

1251758

SC5A4
Probable glucose sensor protein SLC5A4

1

2

High-throughput

0.489

High

1251760

FZD4
Frizzled-4

1

3

High-throughput

0.489

High

1251761

FZD10
Frizzled-10

1

3

High-throughput

0.489

High

1251762

TNF18
Tumor necrosis factor ligand superfamily member 18

1

1

High-throughput

0.489

High

1251763

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

2

High-throughput

0.489

High

1251765

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.489

High

417517

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

1248958

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1139466

S39AE
Metal cation symporter ZIP14

1

8

High-throughput

0.445

High

218358

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

1042757

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

8

High-throughput

0.437

High

1251719

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

251311

NEMF
Ribosome quality control complex subunit NEMF

1

1

High-throughput

0.407

High

704028

5HT1E
5-hydroxytryptamine receptor 1E

1

10

High-throughput

0.407

High

907091

CCR9
C-C chemokine receptor type 9

1

14

High-throughput

0.407

High

1204980

RABL3
Rab-like protein 3

1

1

High-throughput

0.407

High

1239503

ZNT6
Zinc transporter 6

1

6

High-throughput

0.407

High

1246079

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

3

High-throughput

0.407

High

1251759

ATIF1
ATPase inhibitor, mitochondrial

1

1

High-throughput

0.407

High

1251739

TXD15
Thioredoxin domain-containing protein 15

3

0

High-throughput

0.347

High

1032600

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

0

High-throughput

0.328

High

1251724

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.279

Low

1251728

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

1251729

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

588979

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695764

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025