HitPredict

Interactor 1: PDLI1 (O00151)
PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36)
Gene: PDLIM1

Interactor 2: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.695

Property	Details
Experiments	10861853, 26186194, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0005925 - focal adhesion GO:0030018 - Z disc GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 329 Hs			1 894
+	Hs
		117245 PDLI1_HUMAN (1-329): 5.63e-65: 210: 100.00		ACTN1_HUMAN (8-894): 0: 658: 79.48
+	Hs
		117270 PDLI1_HUMAN (1-329): 5.63e-65: 210: 100.00		ACTN3_HUMAN (25-894): 0: 633: 81.03
+	Hs
		117234 PDLI1_HUMAN (1-329): 5.63e-65: 210: 100.00		ACTN4_HUMAN (18-894): 0: 619: 77.89
+	Hs
		521502 PDLI4_HUMAN (4-328): 8.42e-49: 168: 43.43		ACTN1_HUMAN (8-894): 0: 658: 79.48
+	Hs
		725662 PDLI3_HUMAN (5-329): 1.3e-45: 160: 39.72		ACTN2_HUMAN (1-894): 0: 652: 100.00
+	Rn
		1149817 PDLI2_RAT (5-316): 7.57e-42: 150: 29.97		ACTN1_RAT (8-894): 0: 660: 79.48
+	Hs
		254383 LDB3_HUMAN (84-320): 1.46e-30: 123: 18.14		ACTN1_HUMAN (8-894): 0: 658: 79.48
+	Mm
		1337461 LDB3_MOUSE (84-320): 2.04e-30: 123: 18.57		ACTN2_MOUSE (1-894): 0: 655: 99.22
+	Hs
		254385 LDB3_HUMAN (84-320): 1.46e-30: 123: 18.14		ACTN2_HUMAN (1-894): 0: 652: 100.00
+	Hs
		725714 SYNP2_HUMAN (6-174): 4.49e-30: 122: 24.56		ACTN2_HUMAN (1-894): 0: 652: 100.00
+	Rn
		1149816 PDLI2_RAT (5-316): 7.57e-42: 150: 29.97		ACTN4_RAT (18-894): 0: 615: 77.44
+	Mm
		49891 DLG4_MOUSE (1-87): 1e-19: 91.8: 25.53		A1BN54_MOUSE (8-894): 0: 660: 80.16
+	Hs
		725643 DLG4_HUMAN (1-87): 9.22e-20: 92.2: 25.53		ACTN2_HUMAN (1-894): 0: 652: 100.00
+	Hs
		521616 SYP2L_HUMAN (6-258): 2.63e-16: 81.9: 20.16		ACTN1_HUMAN (8-894): 0: 658: 79.48
+	Hs
		725700 SYP2L_HUMAN (6-258): 2.63e-16: 81.9: 20.16		ACTN2_HUMAN (1-894): 0: 652: 100.00
+	Mm
		885081 DLG4_MOUSE (1-87): 1e-19: 91.8: 25.53		ACTN4_MOUSE (18-894): 0: 615: 77.66
+	Ce
		104996 G5EC72_CAEEL (1-314): 3.86e-28: 114: 19.24		Q23158_CAEEL (150-893): 1.52e-11: 70.5: 14.61
+	Ce
		103987 G5EC72_CAEEL (1-314): 3.86e-28: 114: 19.24		G5EBH3_CAEEL (210-831): 7.89e-10: 65.4: 9.81
+	Mm
		57232 A2AKD7_MOUSE (4-256): 2.21e-25: 107: 13.16		SPTB1_MOUSE (254-833): 1.62e-11: 70.9: 11.88
+	Mm
		1143324 DLG4_MOUSE (1-87): 1e-19: 91.8: 25.53		SPTB2_MOUSE (232-802): 1.8e-09: 63.9: 9.98