Protein: HG2A
HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]

Gene: HG2A, CD74
Organism: Homo sapiens
Interactions: 171
UniProt ID: P04233

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001516 - prostaglandin biosynthetic process
GO:0001540 - amyloid-beta binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0001961 - positive regulation of cytokine-mediated signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

407022

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

3

8

High-throughput

0.861

High

380242

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

9

Small-scale

0.789

High

380394

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

2

9

Small-scale

0.754

High

407136

COPG2
Coatomer subunit gamma-2

4

1

High-throughput

0.699

High

407146

COPG1
Coatomer subunit gamma-1

4

1

High-throughput

0.699

High

407075

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

8

High-throughput

0.691

High

407098

T4S20
Transmembrane 4 L6 family member 20

3

0

High-throughput

0.638

High

129952

PGRC1
Membrane-associated progesterone receptor component 1

2

1

High-throughput

0.628

High

380605

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

6

Small-scale

0.618

High

407033

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

9

Small-scale

0.618

High

407112

CLD19
Claudin-19

2

5

High-throughput

0.606

High

407128

CLC7A
C-type lectin domain family 7 member A

2

2

High-throughput

0.606

High

407139

LPAR3
Lysophosphatidic acid receptor 3

2

1

High-throughput

0.606

High

407031

CD44
CD44 antigen

2

1

Small-scale

0.595

High

74149

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

139168

UPK2
Uroplakin-2

2

0

High-throughput

0.580

High

179793

BET1
BET1 homolog

2

0

High-throughput

0.580

High

407027

PEPA4
Pepsin A-4

2

0

High-throughput

0.580

High

407047

FDFT
Squalene synthase

2

0

High-throughput

0.580

High

407065

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.580

High

407074

S35B1
Solute carrier family 35 member B1

2

0

High-throughput

0.580

High

407086

PTC1
Protein patched homolog 1

2

0

High-throughput

0.580

High

407099

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

407102

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.580

High

407104

PLPP4
Phospholipid phosphatase 4

2

0

High-throughput

0.580

High

407110

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.580

High

407113

NRAC
Nutritionally-regulated adipose and cardiac enriched protein homolog

2

0

High-throughput

0.580

High

407115

TM254
Transmembrane protein 254

2

0

High-throughput

0.580

High

407116

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

2

0

High-throughput

0.580

High

407122

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

0

High-throughput

0.580

High

407127

TM243
Transmembrane protein 243

2

0

High-throughput

0.580

High

407130

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.580

High

407131

TMM60
Transmembrane protein 60

2

0

High-throughput

0.580

High

407142

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

76448

B4DUJ2
cDNA FLJ54063, highly similar to Homo sapiens CD74 antigen, transcript variant 2, mRNA

1

1

High-throughput

0.575

High

380511

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

8

High-throughput

0.575

High

407020

HG2A
HLA class II histocompatibility antigen gamma chain

1

10

Small-scale

0.575

High

407038

DMA
HLA class II histocompatibility antigen, DM alpha chain

1

9

Small-scale

0.575

High

407048

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

1

High-throughput

0.560

High

407042

CCR1
C-C chemokine receptor type 1

1

4

High-throughput

0.541

High

407030

MIF
Macrophage migration inhibitory factor

1

0

Small-scale

0.537

High

131279

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

High-throughput

0.536

High

158755

AP3D1
AP-3 complex subunit delta-1

1

2

High-throughput

0.536

High

181228

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.536

High

187855

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

1

High-throughput

0.536

High

325644

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

High-throughput

0.536

High

407029

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.536

High

407036

1433T
14-3-3 protein theta

1

4

High-throughput

0.536

High

407041

1433B
14-3-3 protein beta/alpha

1

4

High-throughput

0.536

High

407045

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

407051

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.536

High

407052

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.536

High

407053

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.536

High

407055

PRC2A
Protein PRRC2A

1

2

High-throughput

0.536

High

407057

DGKE
Diacylglycerol kinase epsilon

1

1

High-throughput

0.536

High

407058

COPB
Coatomer subunit beta

1

1

High-throughput

0.536

High

407059

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

407071

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.536

High

407072

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

2

High-throughput

0.536

High

407078

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

High-throughput

0.536

High

407079

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.536

High

407081

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

2

High-throughput

0.536

High

407083

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.536

High

407087

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.536

High

407094

CND1
Condensin complex subunit 1

1

1

High-throughput

0.536

High

407097

PDCD4
Programmed cell death protein 4

1

2

High-throughput

0.536

High

407100

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

High-throughput

0.536

High

407103

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.536

High

407109

DDX60
Probable ATP-dependent RNA helicase DDX60

1

1

High-throughput

0.536

High

407114

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

1

High-throughput

0.536

High

407125

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.536

High

407133

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.536

High

407135

DJB12
DnaJ homolog subfamily B member 12

1

1

High-throughput

0.536

High

407143

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.536

High

407145

PRC2C
Protein PRRC2C

1

2

High-throughput

0.536

High

407035

CXCR2
C-X-C chemokine receptor type 2

1

3

Small-scale

0.515

High

407068

CXCR4
C-X-C chemokine receptor type 4

1

3

Small-scale

0.515

High

61396

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.513

High

158087

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

164996

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

187625

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

210833

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.513

High

228946

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.513

High

318105

IPO13
Importin-13

1

0

High-throughput

0.513

High

407024

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.513

High

407026

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.513

High

407032

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

407037

CALX
Calnexin

1

0

High-throughput

0.513

High

407039

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.513

High

407046

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.513

High

407049

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

0

High-throughput

0.513

High

407054

COPD
Coatomer subunit delta

1

0

High-throughput

0.513

High

407061

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.513

High

407063

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

407066

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

407067

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.513

High

407069

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

407070

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.513

High

407073

GTF2I
General transcription factor II-I

1

0

High-throughput

0.513

High

407080

CAF1B
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.513

High

407084

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.513

High

407085

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

0

High-throughput

0.513

High

407088

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.513

High

407089

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.513

High

407090

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

407107

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.513

High

407108

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.513

High

407111

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

0

High-throughput

0.513

High

407120

ROP1L
Ropporin-1-like protein

1

0

High-throughput

0.513

High

407121

ASTRA
Protein Aster-A

1

0

High-throughput

0.513

High

407137

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

407138

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.513

High

407140

ZO2
Tight junction protein 2

1

0

High-throughput

0.513

High

407141

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.513

High

407144

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

407023

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

407082

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

1

Small-scale

0.501

High

407093

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.489

High

407096

UBE3C
Ubiquitin-protein ligase E3C

1

1

High-throughput

0.489

High

407101

PRC2B
Protein PRRC2B

1

3

High-throughput

0.489

High

407028

HS71A
Heat shock 70 kDa protein 1A

1

0

Small-scale

0.480

High

295068

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

High-throughput

0.479

High

407021

K2C1
Keratin, type II cytoskeletal 1

1

3

High-throughput

0.479

High

407034

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.479

High

407040

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.479

High

407044

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

407050

EIF1
Eukaryotic translation initiation factor 1

1

1

High-throughput

0.479

High

407076

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

407077

IRF8
Interferon regulatory factor 8

1

1

Small-scale

0.479

High

407092

CND2
Condensin complex subunit 2

1

1

High-throughput

0.479

High

407105

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.479

High

407129

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.479

High

407134

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

219115

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.460

High

407025

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

407043

C2TA
MHC class II transactivator

1

0

Small-scale

0.458

High

407091

CUL7
Cullin-7

1

0

High-throughput

0.458

High

91694

C9JI87
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.445

High

97215

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.445

High

114497

H0YCQ8
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.445

High

116424

H6VRG2
Keratin, type II cytoskeletal 1

1

3

High-throughput

0.445

High

143521

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

2

High-throughput

0.445

High

158613

IF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal

1

1

High-throughput

0.445

High

407118

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

High-throughput

0.445

High

407117

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

Small-scale

0.438

High

407106

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.437

High

407064

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

91560

C9J470
Condensin complex subunit 2

1

1

High-throughput

0.407

High

91862

C9JW96
Prohibitin

1

1

High-throughput

0.407

High

107293

F8VRU2
DNA-directed RNA polymerase

1

1

High-throughput

0.407

High

107298

F8VUA7
Oxysterol-binding protein

1

2

High-throughput

0.407

High

116782

I3L4P8
Heme oxygenase 2

1

1

High-throughput

0.407

High

117257

K7EL20
Eukaryotic translation initiation factor 3 subunit G

1

1

High-throughput

0.407

High

254502

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.407

High

49619

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

407062

EP3B
Epididymal secretory protein E3-beta

2

0

High-throughput

0.316

High

407123

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.316

High

407147

SERP1
Stress-associated endoplasmic reticulum protein 1

2

0

High-throughput

0.316

High

177160

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.279

Low

295274

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.279

Low

317773

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

337667

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

407056

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

407060

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

407095

RCN1
Reticulocalbin-1

1

0

High-throughput

0.279

Low

407119

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.279

Low

407124

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.279

Low

407132

RWDD1
RWD domain-containing protein 1

1

0

High-throughput

0.279

Low

407126

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

117797

M0QYT0
RRM domain-containing protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025