Protein: EIF3G
Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)

Gene: EIF3G
Organism: Homo sapiens
Interactions: 238
UniProt ID: O75821

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

295124

EIF3B
Eukaryotic translation initiation factor 3 subunit B

18

9

Small-scale

0.987

High

295092

IF4B
Eukaryotic translation initiation factor 4B

2

15

Small-scale

0.789

High

295158

G3BP1
Ras GTPase-activating protein-binding protein 1

2

20

High-throughput

0.789

High

295166

EIF3A
Eukaryotic translation initiation factor 3 subunit A

11

8

Small-scale

0.758

High

295159

EIF3I
Eukaryotic translation initiation factor 3 subunit I

12

5

Small-scale

0.757

High

187837

EIF3H
Eukaryotic translation initiation factor 3 subunit H

8

12

Small-scale

0.751

High

295229

EIF3C
Eukaryotic translation initiation factor 3 subunit C

8

4

Small-scale

0.751

High

131257

EIF3F
Eukaryotic translation initiation factor 3 subunit F

8

4

Small-scale

0.748

High

295127

EIF3E
Eukaryotic translation initiation factor 3 subunit E

6

2

Small-scale

0.733

High

295197

EIF3M
Eukaryotic translation initiation factor 3 subunit M

6

1

Small-scale

0.733

High

295259

EIF3L
Eukaryotic translation initiation factor 3 subunit L

5

2

High-throughput

0.718

High

187603

EIF3D
Eukaryotic translation initiation factor 3 subunit D

8

0

Small-scale

0.718

High

295249

EIF3K
Eukaryotic translation initiation factor 3 subunit K

4

1

Small-scale

0.696

High

295091

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.691

High

295147

RACK1
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.691

High

295216

PSPC1
Paraspeckle component 1

1

17

High-throughput

0.691

High

295232

RBM42
RNA-binding protein 42

1

20

High-throughput

0.691

High

295257

G3BP2
Ras GTPase-activating protein-binding protein 2

1

20

High-throughput

0.691

High

295128

IF4A1
Eukaryotic initiation factor 4A-I

3

14

High-throughput

0.667

High

72400

MI4GD
MIF4G domain-containing protein

3

18

Small-scale

0.658

High

295178

PKN2
Serine/threonine-protein kinase N2

1

8

High-throughput

0.656

High

295136

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.656

High

295167

IF4A2
Eukaryotic initiation factor 4A-II

3

12

High-throughput

0.656

High

295048

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

17

Small-scale

0.647

High

240307

PRKN
E3 ubiquitin-protein ligase parkin

3

14

High-throughput

0.640

High

295151

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

3

19

Small-scale

0.640

High

295058

HERC2
E3 ubiquitin-protein ligase HERC2

3

9

Small-scale

0.633

High

295074

IF4E
Eukaryotic translation initiation factor 4E

2

5

High-throughput

0.628

High

295182

CERKL
Ceramide kinase-like protein

2

1

High-throughput

0.628

High

295187

PRC2B
Protein PRRC2B

2

17

High-throughput

0.628

High

295109

HD
Huntingtin

2

6

High-throughput

0.621

High

295087

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.618

High

295113

TISD
mRNA decay activator protein ZFP36L2

1

5

High-throughput

0.618

High

295148

CSK21
Casein kinase II subunit alpha

1

13

High-throughput

0.618

High

295149

SRSF3
Serine/arginine-rich splicing factor 3

1

19

Small-scale

0.618

High

295154

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

12

High-throughput

0.618

High

295169

RBM39
RNA-binding protein 39

1

17

High-throughput

0.618

High

295183

LARP7
La-related protein 7

1

19

High-throughput

0.618

High

295184

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

10

High-throughput

0.618

High

295213

CSK23
Casein kinase II subunit alpha 3

1

11

High-throughput

0.618

High

295218

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

18

High-throughput

0.618

High

295240

RC3H2
Roquin-2

1

12

High-throughput

0.618

High

295251

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

295264

RBM8A
RNA-binding protein 8A

1

17

High-throughput

0.618

High

295123

IF5
Eukaryotic translation initiation factor 5

2

4

Small-scale

0.611

High

295231

PELO
Protein pelota homolog

1

3

Small-scale

0.600

High

295059

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

Small-scale

0.592

High

295080

EPB41
Protein 4.1

1

1

Small-scale

0.586

High

295153

EP300
Histone acetyltransferase p300

2

4

High-throughput

0.584

High

295215

BICD2
Protein bicaudal D homolog 2

2

6

Small-scale

0.584

High

295049

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

Small-scale

0.576

High

295065

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.575

High

295188

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.575

High

295208

FAM9B
Protein FAM9B

1

1

High-throughput

0.573

High

295064

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

295089

RAB5A
Ras-related protein Rab-5A

2

3

High-throughput

0.571

High

295079

TAU
Microtubule-associated protein tau

2

13

High-throughput

0.552

High

81664

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

4

High-throughput

0.536

High

141237

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.536

High

271384

ATG13
Autophagy-related protein 13

1

2

High-throughput

0.536

High

295050

SRP72
Signal recognition particle subunit SRP72

1

2

High-throughput

0.536

High

295072

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

2

High-throughput

0.536

High

295077

SRP19
Signal recognition particle 19 kDa protein

1

1

High-throughput

0.536

High

295083

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

12

High-throughput

0.536

High

295084

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.536

High

295088

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

4

High-throughput

0.536

High

295094

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

295100

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.536

High

295103

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

295107

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

9

High-throughput

0.536

High

295110

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

295111

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.536

High

295112

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

295114

PRC2A
Protein PRRC2A

1

15

High-throughput

0.536

High

295116

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

295119

MAP2
Methionine aminopeptidase 2

1

3

High-throughput

0.536

High

295120

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.536

High

295131

ABCE1
ATP-binding cassette sub-family E member 1

1

2

High-throughput

0.536

High

295132

RS7
Small ribosomal subunit protein eS7

1

2

High-throughput

0.536

High

295133

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.536

High

295134

RS16
Small ribosomal subunit protein uS9

1

6

High-throughput

0.536

High

295137

RS18
Small ribosomal subunit protein uS13

1

2

High-throughput

0.536

High

295138

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.536

High

295139

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.536

High

295142

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.536

High

295143

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.536

High

295164

CUL3
Cullin-3

1

20

High-throughput

0.536

High

295168

CAPR1
Caprin-1

1

5

High-throughput

0.536

High

295170

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

High-throughput

0.536

High

295171

CND2
Condensin complex subunit 2

1

2

High-throughput

0.536

High

295181

LSM12
Protein LSM12

1

4

High-throughput

0.536

High

295185

PDCD4
Programmed cell death protein 4

1

6

High-throughput

0.536

High

295194

DHX57
Putative ATP-dependent RNA helicase DHX57

1

14

High-throughput

0.536

High

295199

NUFP2
FMR1-interacting protein NUFIP2

1

3

High-throughput

0.536

High

295202

KTN1
Kinectin

1

6

High-throughput

0.536

High

295210

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

11

High-throughput

0.536

High

295227

DNJC2
DnaJ homolog subfamily C member 2

1

2

High-throughput

0.536

High

295230

ATX2
Ataxin-2

1

15

High-throughput

0.536

High

295234

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

6

High-throughput

0.536

High

295237

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

18

Small-scale

0.536

High

295252

SRP68
Signal recognition particle subunit SRP68

1

2

High-throughput

0.536

High

295260

DRG1
Developmentally-regulated GTP-binding protein 1

1

3

High-throughput

0.536

High

295262

EMC9
ER membrane protein complex subunit 9

1

3

High-throughput

0.536

High

295263

PRC2C
Protein PRRC2C

1

15

High-throughput

0.536

High

295265

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

295152

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.523

High

254496

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.515

High

278787

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.513

High

295102

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

295108

EIF2D
Eukaryotic translation initiation factor 2D

1

0

High-throughput

0.513

High

295144

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.513

High

295145

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

295146

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

295175

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.513

High

295205

ERI1
3'-5' exoribonuclease 1

1

0

High-throughput

0.513

High

295054

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.508

High

295104

SYUA
Alpha-synuclein

1

2

High-throughput

0.508

High

295122

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.508

High

295160

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.508

High

295180

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

185299

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

295071

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

295057

KLF8
Krueppel-like factor 8

1

10

High-throughput

0.500

High

295256

CAN11
Calpain-11

1

0

High-throughput

0.493

High

295078

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

295117

CTCF
Transcriptional repressor CTCF

1

3

High-throughput

0.489

High

295212

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.489

High

295241

ENY2
Transcription and mRNA export factor ENY2

1

3

High-throughput

0.489

High

295066

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

295063

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.481

High

295118

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

295165

TRI14
Tripartite motif-containing protein 14

1

8

High-throughput

0.481

High

295200

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

Small-scale

0.480

High

131628

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

216037

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

20

High-throughput

0.479

High

295051

RECQ4
ATP-dependent DNA helicase Q4

1

12

High-throughput

0.479

High

295052

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

295053

HEXI1
Protein HEXIM1

1

4

High-throughput

0.479

High

295055

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.479

High

295060

SNAI1
Zinc finger protein SNAI1

1

5

High-throughput

0.479

High

295061

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.479

High

295062

RASK
GTPase KRas

1

3

High-throughput

0.479

High

295068

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.479

High

295070

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

295075

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

295081

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.479

High

295086

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

295090

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

295093

DDX6
Probable ATP-dependent RNA helicase DDX6

1

13

High-throughput

0.479

High

295096

PML
Protein PML

1

14

High-throughput

0.479

High

295097

1433S
14-3-3 protein sigma

1

8

Small-scale

0.479

High

295098

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

295105

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

295106

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

295121

TTC3
E3 ubiquitin-protein ligase TTC3

1

8

High-throughput

0.479

High

295126

CD81
CD81 antigen

1

1

High-throughput

0.479

High

295129

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

295130

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

295135

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

295140

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

295141

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.479

High

295155

NFX1
Transcriptional repressor NF-X1

1

5

High-throughput

0.479

High

295156

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.479

High

295161

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

3

High-throughput

0.479

High

295162

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

3

High-throughput

0.479

High

295172

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

295173

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

295174

PCBP1
Poly(rC)-binding protein 1

1

20

Small-scale

0.479

High

295176

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

295177

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

295189

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

295190

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

295196

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

295201

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

295203

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

295204

ZCH18
Zinc finger CCCH domain-containing protein 18

1

7

High-throughput

0.479

High

295207

DDX60
Probable ATP-dependent RNA helicase DDX60

1

11

High-throughput

0.479

High

295209

CMTR1
Cap-specific mRNA

1

2

High-throughput

0.479

High

295211

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

295217

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

295220

CSN5
COP9 signalosome complex subunit 5

1

10

High-throughput

0.479

High

295223

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

295236

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

295238

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.479

High

295242

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

4

High-throughput

0.479

High

295243

ANLN
Anillin

1

6

High-throughput

0.479

High

295244

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

295246

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

295250

DUX4
Double homeobox protein 4

1

9

High-throughput

0.479

High

295253

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

295255

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

295258

ANGE1
Protein angel homolog 1

1

4

High-throughput

0.479

High

295261

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.479

High

295191

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

295056

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

295099

GCYA2
Guanylate cyclase soluble subunit alpha-2

1

0

High-throughput

0.458

High

295179

NREP
Neuronal regeneration-related protein

1

0

Small-scale

0.458

High

295233

KLF16
Krueppel-like factor 16

1

5

High-throughput

0.457

High

295254

KLF15
Krueppel-like factor 15

1

5

High-throughput

0.457

High

295082

TCTP
Translationally-controlled tumor protein

1

3

Small-scale

0.445

High

295163

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.445

High

295186

ODFP2
Outer dense fiber protein 2

1

2

High-throughput

0.445

High

295192

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

295226

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.445

High

295266

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

1

High-throughput

0.445

High

295228

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.438

High

104970

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

259226

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

276020

NIPS2
Protein NipSnap homolog 2

1

1

Small-scale

0.437

High

295067

MYCN
N-myc proto-oncogene protein

1

14

High-throughput

0.437

High

295069

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.437

High

295073

ICAM1
Intercellular adhesion molecule 1

1

7

High-throughput

0.437

High

295085

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

295095

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

295101

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

295115

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

295125

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.437

High

295150

RUNX1
Runt-related transcription factor 1

1

2

High-throughput

0.437

High

295157

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.437

High

295193

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.437

High

295198

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

295214

TIP
T-cell immunomodulatory protein

1

4

High-throughput

0.437

High

295219

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

295221

IGSF8
Immunoglobulin superfamily member 8

1

5

High-throughput

0.437

High

295225

CIC
Protein capicua homolog

1

13

High-throughput

0.437

High

295235

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

295248

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

87285

OSCRI
SCRIB overlapping open reading frame protein

1

3

High-throughput

0.407

High

295206

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

295222

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.299

High

295195

PKHG7
Pleckstrin homology domain-containing family G member 7

2

0

High-throughput

0.298

High

295245

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

248547

FADS1
Acyl-CoA

1

0

High-throughput

0.279

Low

295247

PALS2
Protein PALS2

1

0

High-throughput

0.251

Low

295076

5HT1A
5-hydroxytryptamine receptor 1A

1

0

Small-scale

0.249

Low

295224

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low

295239

GHC1
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025