HitPredict

Interactor 1: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Interactor 2: DOT1L (Q8TEK3)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	22373577, 21726816, 20203130
Identification Methods	affinity chromatography technology, enzymatic study, methyltransferase assay
Interaction Type	physical association, direct interaction, methylation reaction

Property	Details
Interacting Pfam domains	DOT1~Histone
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 1537
+	Hs
		1086235 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		952487 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		828312 CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Sc
		902044 H3_YEAST (1-136): 7.77e-56: 172: 88.97		DOT1_YEAST (34-358): 8.07e-120: 390: 28.05