HitPredict

Interactor 1: HECW1 (Q76N89)
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Gene: HECW1

Interactor 2: FXL15 (Q9H469)
F-box/LRR-repeat protein 15 (F-box only protein 37)
Gene: FBXL15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21572392
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1606 Hs			1 300
+	Hs
		1330595 HECW2_HUMAN (22-1606): 0: 955: 55.12		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1294860 ITCH_HUMAN (865-1606): 0: 695: 30.78		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		808271 NEDD4_HUMAN (307-1604): 0: 656: 21.43		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1330593 SMUF2_HUMAN (1017-1606): 0: 646: 35.34		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1330594 SMUF1_HUMAN (1034-1606): 0: 611: 33.82		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		808329 NEDD4_HUMAN (307-1604): 0: 656: 21.43		KDM2A_HUMAN (24-284): 2.19e-35: 137: 15.88
+	Hs
		1336111 SMUF1_HUMAN (1034-1606): 0: 611: 33.82		FBXL2_HUMAN (5-249): 1.36e-30: 120: 22.05
+	Hs
		983275 UBE3A_HUMAN (1151-1605): 1.17e-159: 509: 28.39		KDM2A_HUMAN (24-284): 2.19e-35: 137: 15.88
+	Hs
		125710 WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1327912 WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00
+	Hs
		1299633 NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96		FXL15_HUMAN (1-300): 3.34e-68: 215: 100.00