HitPredict

Interactor 1: Q7JUX2 (Q7JUX2)
Deneddylase 1, isoform A (RE42624p)
Gene: Den1

Interactor 2: NEDD8 (Q9VJ33)
NEDD8 (Neddylin) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.80	0.743

Property	Details
Experiments	14605208, 18782863
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Peptidase_C48~ubiquitin
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 215 Dm			1 84
+	Hs
		924415 SENP2_HUMAN (3-206): 1.15e-71: 229: 23.15		RL40_HUMAN (1-81): 8.37e-36: 119: 54.32
+	Hs
		1079578 SENP8_HUMAN (8-214): 9.25e-65: 201: 36.49		NEDD8_HUMAN (1-76): 1.22e-39: 127: 93.42
+	Mm
		669127 SENP8_MOUSE (8-214): 1.14e-65: 203: 37.44		NEDD8_MOUSE (1-68): 2.75e-33: 111: 92.65
+	Sp
		141976 NEP2_SCHPO (9-211): 1.6e-48: 165: 27.10		UBL1_SCHPO (1-76): 4.36e-36: 118: 81.58
+	Sp
		145587 NESP1_SCHPO (6-213): 2.17e-48: 165: 25.11		UBL1_SCHPO (1-76): 4.36e-36: 118: 81.58
+	Ce
		1197285 Q86FN3_CAEEL (10-214): 2.85e-45: 151: 29.86		NEDD8_CAEEL (1-77): 2.45e-35: 116: 88.31