Protein: ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]

Gene: ATF6A, ATF6
Organism: Homo sapiens
Interactions: 124
UniProt ID: P18850

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

617269

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

5

17

Small-scale

0.912

High

608955

XBP1
X-box-binding protein 1

2

19

High-throughput

0.778

High

617340

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

2

18

Small-scale

0.767

High

593017

CREB1
Cyclic AMP-responsive element-binding protein 1

1

17

High-throughput

0.698

High

617334

ERLEC
Endoplasmic reticulum lectin 1

3

5

High-throughput

0.667

High

617309

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

18

Small-scale

0.665

High

617348

FBX6
F-box only protein 6

3

2

High-throughput

0.633

High

163375

GBRD
Gamma-aminobutyric acid receptor subunit delta

2

1

High-throughput

0.628

High

617275

CADH5
Cadherin-5

2

5

High-throughput

0.628

High

617296

OS9
Protein OS-9

2

5

High-throughput

0.628

High

617322

STK40
Serine/threonine-protein kinase 40

2

20

High-throughput

0.628

High

617327

COP1
E3 ubiquitin-protein ligase COP1

2

7

High-throughput

0.628

High

617273

TYY1
Transcriptional repressor protein YY1

2

9

Small-scale

0.624

High

617299

NFYC
Nuclear transcription factor Y subunit gamma

2

1

Small-scale

0.619

High

617279

CEBPD
CCAAT/enhancer-binding protein delta

1

20

Small-scale

0.618

High

617307

CRTC2
CREB-regulated transcription coactivator 2

1

8

Small-scale

0.618

High

568034

HLAE
HLA class I histocompatibility antigen, alpha chain E

2

1

High-throughput

0.611

High

617358

FBX2
F-box only protein 2

2

2

High-throughput

0.601

High

288164

CLC3A
C-type lectin domain family 3 member A

2

3

High-throughput

0.574

High

617323

PCD20
Protocadherin-20

2

5

High-throughput

0.574

High

617342

PCDC1
Protocadherin alpha-C1

2

5

High-throughput

0.574

High

617291

SRBP2
Sterol regulatory element-binding protein 2

1

15

Small-scale

0.561

High

617339

SEC62
Translocation protein SEC62

2

0

High-throughput

0.559

High

617337

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

Small-scale

0.552

High

459832

PMGE
Bisphosphoglycerate mutase

1

4

High-throughput

0.541

High

617270

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

High-throughput

0.541

High

617286

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

2

High-throughput

0.541

High

617321

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.537

High

617283

DAPK1
Death-associated protein kinase 1

1

20

High-throughput

0.536

High

276207

LRRN2
Leucine-rich repeat neuronal protein 2

1

3

High-throughput

0.536

High

380404

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.536

High

423735

APOD
Apolipoprotein D

1

5

High-throughput

0.536

High

539693

ACHB
Acetylcholine receptor subunit beta

1

2

High-throughput

0.536

High

617274

CALX
Calnexin

1

6

High-throughput

0.536

High

617298

FHL3
Four and a half LIM domains protein 3

1

8

High-throughput

0.536

High

617302

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

1

High-throughput

0.536

High

617303

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

617329

KCNG4
Voltage-gated potassium channel regulatory subunit KCNG4

1

1

High-throughput

0.536

High

617338

TRIB1
Tribbles homolog 1

1

15

High-throughput

0.536

High

617346

CP26B
Cytochrome P450 26B1

1

3

High-throughput

0.536

High

617349

PCDBG
Protocadherin beta-16

1

4

High-throughput

0.536

High

617356

CLC2D
C-type lectin domain family 2 member D

1

6

High-throughput

0.536

High

617363

PCDBB
Protocadherin beta-11

1

4

High-throughput

0.536

High

549279

SRF
Serum response factor

1

1

Small-scale

0.527

High

617271

DDC
Aromatic-L-amino-acid decarboxylase

1

0

High-throughput

0.518

High

617276

NNMT
Nicotinamide N-methyltransferase

1

0

High-throughput

0.518

High

617280

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.513

High

617284

ACLY
ATP-citrate synthase

1

0

High-throughput

0.513

High

617293

LMAN2
Vesicular integral-membrane protein VIP36

1

0

High-throughput

0.513

High

617306

CLM2
CMRF35-like molecule 2

1

0

High-throughput

0.513

High

617316

DET1
DET1 homolog

1

0

High-throughput

0.513

High

617318

PARG
Poly(ADP-ribose) glycohydrolase

1

0

High-throughput

0.513

High

617328

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

617332

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

617353

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

1

0

High-throughput

0.513

High

421468

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

617345

SAR1A
Small COPII coat GTPase SAR1A

1

5

Small-scale

0.500

High

561005

IL7
Interleukin-7

1

1

High-throughput

0.489

High

617285

EP3B
Epididymal secretory protein E3-beta

1

1

High-throughput

0.489

High

617300

KCNC3
Voltage-gated potassium channel KCNC3

1

3

High-throughput

0.489

High

617314

BTNL3
Butyrophilin-like protein 3

1

10

High-throughput

0.489

High

617319

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

617330

S3TC1
SH3 domain and tetratricopeptide repeat-containing protein 1

1

4

High-throughput

0.489

High

617357

BTNL2
Butyrophilin-like protein 2

1

5

High-throughput

0.489

High

617364

PCDGM
Protocadherin gamma-C5

1

3

High-throughput

0.489

High

617365

PCDG7
Protocadherin gamma-A7

1

4

High-throughput

0.489

High

617272

NFYA
Nuclear transcription factor Y subunit alpha

1

4

Small-scale

0.481

High

214382

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

Small-scale

0.479

High

617335

DNJC1
DnaJ homolog subfamily C member 1

1

5

High-throughput

0.479

High

217809

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

282564

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

17

Small-scale

0.479

High

417255

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

507509

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

534609

BIP
Endoplasmic reticulum chaperone BiP

1

5

Small-scale

0.479

High

617278

SOX2
Transcription factor SOX-2

1

12

Small-scale

0.479

High

617281

EMD
Emerin

1

1

High-throughput

0.479

High

617282

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

617287

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

617288

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

617290

PO5F1
POU domain, class 5, transcription factor 1

1

11

Small-scale

0.479

High

617292

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

617301

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

617305

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.479

High

617313

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

617317

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

6

Small-scale

0.479

High

617331

RN139
E3 ubiquitin-protein ligase RNF139

1

5

High-throughput

0.479

High

617343

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.479

High

617352

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

17

Small-scale

0.479

High

617355

SEC63
Translocation protein SEC63 homolog

1

4

High-throughput

0.479

High

617359

DJC16
DnaJ homolog subfamily C member 16

1

6

High-throughput

0.479

High

278807

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

301332

WFS1
Wolframin

1

0

Small-scale

0.458

High

617277

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

617289

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

617297

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

617324

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

617333

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

617336

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

617341

DERL1
Derlin-1

1

0

High-throughput

0.458

High

617344

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

617347

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

617351

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

617362

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

138448

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.457

High

170655

CLGN
Calmegin

1

6

High-throughput

0.445

High

617294

DNJC3
DnaJ homolog subfamily C member 3

1

2

High-throughput

0.445

High

617295

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

2

High-throughput

0.445

High

617304

SL9A5
Sodium/hydrogen exchanger 5

1

4

High-throughput

0.445

High

617308

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

617311

S27A4
Long-chain fatty acid transport protein 4

1

8

High-throughput

0.445

High

617312

S27A1
Long-chain fatty acid transport protein 1

1

8

High-throughput

0.445

High

617326

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

617354

SL9A2
Sodium/hydrogen exchanger 2

1

4

High-throughput

0.445

High

617360

S27A6
Long-chain fatty acid transport protein 6

1

8

High-throughput

0.445

High

617361

S27A5
Long-chain fatty acid transport protein 5

1

8

High-throughput

0.445

High

617320

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

617325

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.426

High

379335

IGHG2
Immunoglobulin heavy constant gamma 2

1

2

High-throughput

0.407

High

379453

IGHG4
Immunoglobulin heavy constant gamma 4

1

2

High-throughput

0.407

High

617310

SL9A4
Sodium/hydrogen exchanger 4

1

4

High-throughput

0.407

High

351815

BY55
CD160 antigen

1

0

High-throughput

0.279

Low

617315

ZY11A
Protein zyg-11 homolog A

1

0

High-throughput

0.279

Low

617350

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025