HitPredict

Interactor 1: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Interactor 2: RHG30 (Q7Z6I6)
Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)
Gene: ARHGAP30

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	1.00	0.653

Property	Details
Experiments	21565175
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0051056 - regulation of small GTPase mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 258 Hs			1 1101
+	Hs
		64644 RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96		RHG32_HUMAN (3-654): 1.42e-83: 301: 32.95
+	Hs
		64679 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		RHG32_HUMAN (3-654): 1.42e-83: 301: 32.95
+	Hs
		64692 RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93		RHG32_HUMAN (3-654): 1.42e-83: 301: 32.95
+	Dm
		776916 RAC1_DROME (48-234): 3.68e-84: 251: 54.55		CDGAP_DROME (3-710): 1.19e-77: 283: 22.21
+	Hs
		253371 RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00		SRGP2_HUMAN (1-630): 9.15e-77: 276: 13.73
+	Dm
		776930 RAC1_DROME (48-234): 3.68e-84: 251: 54.55		RHGF_DROME (35-569): 1.29e-76: 275: 15.47
+	Hs
		253333 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		SRGP2_HUMAN (1-630): 9.15e-77: 276: 13.73
+	Hs
		436289 RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96		MYO9B_HUMAN (7-490): 8.28e-71: 261: 19.23
+	Hs
		70701 RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66		MYO9A_HUMAN (1-481): 5.28e-70: 259: 19.41
+	Hs
		892420 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		RHG21_HUMAN (4-688): 7.84e-71: 261: 18.62
+	Hs
		436280 RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96		RHG05_HUMAN (18-239): 7.93e-65: 242: 25.11
+	Hs
		1219673 RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66		RHG12_HUMAN (5-216): 3.76e-67: 244: 34.27
+	Hs
		892620 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		RHG35_HUMAN (10-241): 8.76e-68: 251: 24.89
+	Hs
		892343 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		RHG05_HUMAN (18-239): 7.93e-65: 242: 25.11
+	Hs
		436273 RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96		RHG01_HUMAN (1-222): 2.9e-63: 223: 27.47
+	Hs
		63072 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		RHG42_HUMAN (36-392): 6.35e-65: 238: 24.35
+	Dm
		776920 RAC1_DROME (48-234): 3.68e-84: 251: 54.55		RG68F_DROME (3-215): 4.73e-62: 221: 26.15
+	Hs
		892334 RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96		RHG01_HUMAN (1-222): 2.9e-63: 223: 27.47
+	Sp
		251348 CDC42_SCHPO (50-234): 9.09e-90: 265: 52.43		RGA4_SCHPO (33-216): 3.65e-19: 95.5: 30.32
+	Hs
		1071112 RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00		RBP1_HUMAN (22-220): 2.31e-18: 92.4: 30.00