Protein: NFYB
Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB)

Gene: NFYB
Organism: Homo sapiens
Interactions: 45
UniProt ID: P25208

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

659655

NFYA
Nuclear transcription factor Y subunit alpha

10

11

Small-scale

0.978

High

670077

NFYC
Nuclear transcription factor Y subunit gamma

9

20

Small-scale

0.977

High

670087

DPOE4
DNA polymerase epsilon subunit 4

4

20

High-throughput

0.904

High

670078

NC2A
Dr1-associated corepressor

2

20

High-throughput

0.834

High

628700

TBP
TATA-box-binding protein

1

4

Small-scale

0.724

High

670074

EP300
Histone acetyltransferase p300

3

3

Small-scale

0.667

High

413218

P53
Cellular tumor antigen p53

3

1

Small-scale

0.656

High

186704

P73
Tumor protein p73

2

1

Small-scale

0.584

High

371194

MYC
Myc proto-oncogene protein

1

1

Small-scale

0.561

High

670070

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.541

High

670086

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.518

High

670082

Q6FHY5
MEOX2 protein

1

4

High-throughput

0.515

High

670073

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

Small-scale

0.504

High

670080

TAF11
Transcription initiation factor TFIID subunit 11

1

3

Small-scale

0.501

High

670069

MEOX2
Homeobox protein MOX-2

1

4

High-throughput

0.481

High

629504

PO3F2
POU domain, class 3, transcription factor 2

1

0

Small-scale

0.480

High

670068

TAF6
Transcription initiation factor TFIID subunit 6

1

0

Small-scale

0.480

High

670081

TAF12
Transcription initiation factor TFIID subunit 12

1

0

Small-scale

0.480

High

464818

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

573752

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.479

High

606244

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

629062

CCNA2
Cyclin-A2

1

1

Small-scale

0.479

High

666941

CCNE1
G1/S-specific cyclin-E1

1

2

Small-scale

0.479

High

667530

CDK2
Cyclin-dependent kinase 2

1

7

Small-scale

0.479

High

670075

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

670076

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.479

High

670079

BRD3
Bromodomain-containing protein 3

1

9

High-throughput

0.479

High

670084

CBP
CREB-binding protein

1

2

Small-scale

0.479

High

670085

KAT2B
Histone acetyltransferase KAT2B

1

9

Small-scale

0.479

High

295457

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

Small-scale

0.458

High

403833

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

463342

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.458

High

593023

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

608957

XBP1
X-box-binding protein 1

1

0

Small-scale

0.458

High

380693

HBAZ
Hemoglobin subunit zeta

1

1

Small-scale

0.437

High

670071

HBA
Hemoglobin subunit alpha

1

1

Small-scale

0.437

High

670083

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

670065

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.282

High

670067

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

441525

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

561902

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

670088

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low

551732

COBA1

1

0

Small-scale

0.249

Low

670066

TGFR2
TGF-beta receptor type-2

1

0

Small-scale

0.249

Low

670072

GCYB1
Guanylate cyclase soluble subunit beta-1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025