HitPredict

Interactor 1: EYA2 (O00167)
Eyes absent homolog 2 (EC 3.1.3.48)
Gene: EYA2

Interactor 2: SIX4 (Q9UIU6)
Homeobox protein SIX4 (Sine oculis homeobox homolog 4)
Gene: SIX4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	27880917, 10490620
Identification Methods	proximity labelling technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 538 Hs			1 781
+	Mm
		139225 EYA2_MOUSE (1-538): 0: 588: 87.92		SIX4_MOUSE (1-781): 0: 1084: 90.28
+	Mm
		956884 EYA1_MOUSE (3-538): 0: 522: 62.09		SIX4_MOUSE (1-781): 0: 1084: 90.28
+	Hs
		1304297 EYA1_HUMAN (3-538): 0: 523: 62.50		SIX4_HUMAN (1-781): 0: 1062: 100.00
+	Hs
		318748 EYA4_HUMAN (1-538): 2.16e-177: 515: 56.22		SIX4_HUMAN (1-781): 0: 1062: 100.00
+	Mm
		936193 EYA1_MOUSE (3-538): 0: 522: 62.09		SIX5_MOUSE (97-570): 4.47e-146: 447: 38.90
+	Hs
		118562 EYA2_HUMAN (1-538): 0: 616: 100.00		SIX1_HUMAN (100-396): 1.56e-114: 350: 47.48
+	Hs
		1230644 EYA1_HUMAN (3-538): 0: 523: 62.50		SIX5_HUMAN (86-570): 1.44e-143: 441: 36.21
+	Hs
		318670 EYA4_HUMAN (1-538): 2.16e-177: 515: 56.22		SIX5_HUMAN (86-570): 1.44e-143: 441: 36.21
+	Hs
		118611 EYA2_HUMAN (1-538): 0: 616: 100.00		SIX2_HUMAN (100-382): 3.15e-110: 339: 49.30
+	Mm
		936192 EYA3_MOUSE (9-538): 2.11e-172: 498: 46.08		SIX5_MOUSE (97-570): 4.47e-146: 447: 38.90
+	Hs
		1074456 EYA1_HUMAN (3-538): 0: 523: 62.50		SIX1_HUMAN (100-396): 1.56e-114: 350: 47.48
+	Mm
		956885 EYA1_MOUSE (3-538): 0: 522: 62.09		SIX1_MOUSE (100-400): 6.2e-114: 348: 46.84
+	Hs
		318622 EYA4_HUMAN (1-538): 2.16e-177: 515: 56.22		SIX1_HUMAN (100-396): 1.56e-114: 350: 47.48
+	Mm
		956886 EYA1_MOUSE (3-538): 0: 522: 62.09		SIX2_MOUSE (100-358): 6.06e-111: 341: 51.35
+	Hs
		1304296 EYA1_HUMAN (3-538): 0: 523: 62.50		SIX2_HUMAN (100-382): 3.15e-110: 339: 49.30
+	Hs
		318733 EYA4_HUMAN (1-538): 2.16e-177: 515: 56.22		SIX2_HUMAN (100-382): 3.15e-110: 339: 49.30
+	Hs
		92587 E9PLN6_HUMAN (1-538): 6.08e-173: 504: 54.41		SIX1_HUMAN (100-396): 1.56e-114: 350: 47.48
+	Mm
		956578 EYA3_MOUSE (9-538): 2.11e-172: 498: 46.08		SIX1_MOUSE (100-400): 6.2e-114: 348: 46.84
+	Hs
		92588 E9PLN6_HUMAN (1-538): 6.08e-173: 504: 54.41		SIX2_HUMAN (100-382): 3.15e-110: 339: 49.30
+	Mm
		956887 EYA1_MOUSE (3-538): 0: 522: 62.09		SIX3_MOUSE (95-350): 7.96e-96: 303: 42.69