Protein: ATN1
Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)

Gene: ATN1
Organism: Homo sapiens
Interactions: 186
UniProt ID: P54259

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001906 - cell killing
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

928254

WDR5
WD repeat-containing protein 5

7

17

High-throughput

0.750

High

928267

MTG8
Protein CBFA2T1

3

10

Small-scale

0.671

High

928359

RERE
Arginine-glutamic acid dipeptide repeats protein

3

18

Small-scale

0.653

High

928367

BAIP2
BAR/IMD domain-containing adapter protein 2

2

9

Small-scale

0.653

High

131854

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

14

Small-scale

0.629

High

928262

EWS
RNA-binding protein EWS

2

18

High-throughput

0.614

High

928323

LENG8
Leukocyte receptor cluster member 8

2

9

High-throughput

0.613

High

928274

RBBP5
Retinoblastoma-binding protein 5

2

20

High-throughput

0.601

High

928299

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

4

High-throughput

0.595

High

928343

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

15

Small-scale

0.595

High

861948

YAP1
Transcriptional coactivator YAP1

2

20

High-throughput

0.595

High

928361

ZN608
Zinc finger protein 608

2

11

Small-scale

0.595

High

928371

NR2E1
Nuclear receptor subfamily 2 group E member 1

2

20

Small-scale

0.594

High

928277

TRIP6
Thyroid receptor-interacting protein 6

1

4

High-throughput

0.582

High

928355

RFOX1
RNA binding protein fox-1 homolog 1

1

14

High-throughput

0.573

High

928334

RHXF2
Rhox homeobox family member 2

1

20

High-throughput

0.552

High

180498

PLS1
Phospholipid scramblase 1

1

2

High-throughput

0.541

High

222043

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.541

High

899794

FXR1
RNA-binding protein FXR1

1

16

High-throughput

0.541

High

900257

FXR2
RNA-binding protein FXR2

1

16

High-throughput

0.541

High

928253

PSME3
Proteasome activator complex subunit 3

1

3

High-throughput

0.541

High

928308

TSC1
Hamartin

1

10

High-throughput

0.541

High

928312

RBPMS
RNA-binding protein with multiple splicing

1

1

High-throughput

0.541

High

928335

EFC4B
EF-hand calcium-binding domain-containing protein 4B

1

1

High-throughput

0.541

High

928306

AUTS2
Autism susceptibility gene 2 protein

1

18

Small-scale

0.536

High

928322

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

11

High-throughput

0.536

High

928298

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

17

Small-scale

0.527

High

928319

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

15

Small-scale

0.527

High

928324

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

11

Small-scale

0.527

High

928329

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

895427

SPB8
Serpin B8

1

1

High-throughput

0.515

High

928272

BECN1
Beclin-1

1

0

Small-scale

0.513

High

159578

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

5

High-throughput

0.508

High

211294

RFOX2
RNA binding protein fox-1 homolog 2

1

15

High-throughput

0.508

High

211552

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

6

High-throughput

0.508

High

216168

MTG8R
Protein CBFA2T2

1

4

High-throughput

0.508

High

681304

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.508

High

856604

BAG6
Large proline-rich protein BAG6

1

19

High-throughput

0.508

High

875597

PRC2A
Protein PRRC2A

1

20

High-throughput

0.508

High

928246

ATN1
Atrophin-1

1

15

High-throughput

0.508

High

928252

ARF3
ADP-ribosylation factor 3

1

1

High-throughput

0.508

High

928260

LRP2
Low-density lipoprotein receptor-related protein 2

1

1

High-throughput

0.508

High

928261

RBM10
RNA-binding protein 10

1

6

High-throughput

0.508

High

928268

TLE5
TLE family member 5

1

7

High-throughput

0.508

High

928279

MA7D1
MAP7 domain-containing protein 1

1

11

High-throughput

0.508

High

928296

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

20

High-throughput

0.508

High

928297

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

High-throughput

0.508

High

928307

KAT6B
Histone acetyltransferase KAT6B

1

20

High-throughput

0.508

High

928309

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.508

High

928311

NELL1
Protein kinase C-binding protein NELL1

1

13

High-throughput

0.508

High

928325

SPAG5
Sperm-associated antigen 5

1

12

High-throughput

0.508

High

928326

NELL2
Protein kinase C-binding protein NELL2

1

17

High-throughput

0.508

High

928330

TEP1
Telomerase protein component 1

1

15

High-throughput

0.508

High

928350

CPAP
Centrosomal P4.1-associated protein

1

6

High-throughput

0.508

High

928360

FBLN5
Fibulin-5

1

14

High-throughput

0.508

High

928363

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

20

High-throughput

0.508

High

928368

JAG2
Protein jagged-2

1

5

High-throughput

0.508

High

928372

ARIP4
Helicase ARIP4

1

18

High-throughput

0.508

High

928349

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.506

High

928313

GCC1
GRIP and coiled-coil domain-containing protein 1

1

11

High-throughput

0.494

High

928332

KR412
Keratin-associated protein 4-12

1

7

High-throughput

0.494

High

928341

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

15

High-throughput

0.494

High

388058

MBP
Myelin basic protein

1

0

High-throughput

0.486

High

928321

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.486

High

169487

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

8

High-throughput

0.481

High

273988

CREST
Calcium-responsive transactivator

1

19

High-throughput

0.481

High

288381

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

8

High-throughput

0.481

High

331982

KAT7
Histone acetyltransferase KAT7

1

8

High-throughput

0.481

High

335277

TFIP8
Tumor necrosis factor alpha-induced protein 8

1

1

High-throughput

0.481

High

347597

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.481

High

408760

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.481

High

474572

VIME
Vimentin

1

9

High-throughput

0.481

High

912821

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

15

High-throughput

0.481

High

928255

CSK21
Casein kinase II subunit alpha

1

15

High-throughput

0.481

High

928257

PITX1
Pituitary homeobox 1

1

20

High-throughput

0.481

High

928265

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.481

High

928271

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.481

High

928290

OLIG3
Oligodendrocyte transcription factor 3

1

15

High-throughput

0.481

High

928294

SAXO4
Stabilizer of axonemal microtubules 4

1

1

High-throughput

0.481

High

928295

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.481

High

928318

ZN503
Zinc finger protein 503

1

1

High-throughput

0.481

High

928320

RBM14
RNA-binding protein 14

1

13

High-throughput

0.481

High

928327

PITX2
Pituitary homeobox 2

1

20

High-throughput

0.481

High

928328

LYST
Lysosomal-trafficking regulator

1

15

Small-scale

0.481

High

928331

RBM4B
RNA-binding protein 4B

1

13

High-throughput

0.481

High

928333

HINFP
Histone H4 transcription factor

1

10

Small-scale

0.481

High

928339

TEKT3
Tektin-3

1

2

High-throughput

0.481

High

928340

DGC6L
Protein DGCR6L

1

1

High-throughput

0.481

High

928352

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

1

High-throughput

0.481

High

928354

EKI2
Ethanolamine kinase 2

1

1

High-throughput

0.481

High

928366

CTND2
Catenin delta-2

1

13

Small-scale

0.481

High

928370

NOC2L
Nucleolar complex protein 2 homolog

1

1

High-throughput

0.481

High

71435

P20L1
PHD finger protein 20-like protein 1

1

5

High-throughput

0.479

High

128885

MEN1
Menin

1

6

High-throughput

0.479

High

142911

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

174330

ZN609
Zinc finger protein 609

1

15

High-throughput

0.479

High

175863

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.479

High

181495

TBXT
T-box transcription factor T

1

16

High-throughput

0.479

High

209973

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

284814

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.479

High

316793

MTA2
Metastasis-associated protein MTA2

1

18

High-throughput

0.479

High

341541

EYA4
Protein phosphatase EYA4

1

20

High-throughput

0.479

High

378483

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.479

High

519873

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

538378

EGR2
E3 SUMO-protein ligase EGR2

1

9

High-throughput

0.479

High

639694

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

725224

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

905362

HCFC1
Host cell factor 1

1

15

High-throughput

0.479

High

928247

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.479

High

928248

FOXA1
Hepatocyte nuclear factor 3-alpha

1

16

High-throughput

0.479

High

928249

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

928250

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.479

High

928256

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

928264

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.479

High

928266

TLE3
Transducin-like enhancer protein 3

1

19

High-throughput

0.479

High

928276

TERF2
Telomeric repeat-binding factor 2

1

4

High-throughput

0.479

High

928286

GGYF2
GRB10-interacting GYF protein 2

1

11

Small-scale

0.479

High

928291

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

928292

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

928300

ZZZ3
ZZ-type zinc finger-containing protein 3

1

1

High-throughput

0.479

High

928302

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

928303

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

928304

NUP35
Nucleoporin NUP35

1

5

High-throughput

0.479

High

928305

SP7
Transcription factor Sp7

1

18

High-throughput

0.479

High

928314

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.479

High

928316

SGF29
SAGA-associated factor 29

1

1

High-throughput

0.479

High

928317

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

928337

PHF20
PHD finger protein 20

1

14

High-throughput

0.479

High

928338

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.479

High

928345

KAT8
Histone acetyltransferase KAT8

1

8

High-throughput

0.479

High

928346

CSR2B
Cysteine-rich protein 2-binding protein

1

10

High-throughput

0.479

High

928348

KANL2
KAT8 regulatory NSL complex subunit 2

1

2

High-throughput

0.479

High

928353

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

928356

WWOX
WW domain-containing oxidoreductase

1

5

High-throughput

0.479

High

928357

CXXC1
CXXC-type zinc finger protein 1

1

19

High-throughput

0.479

High

928358

KANL3
KAT8 regulatory NSL complex subunit 3

1

2

High-throughput

0.479

High

928362

YETS2
YEATS domain-containing protein 2

1

20

High-throughput

0.479

High

928364

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.479

High

928365

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

928369

KDM2A
Lysine-specific demethylase 2A

1

6

Small-scale

0.479

High

928374

HCFC2
Host cell factor 2

1

13

High-throughput

0.479

High

64295

MEG11
Multiple epidermal growth factor-like domains protein 11

1

6

High-throughput

0.464

High

136858

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

7

High-throughput

0.464

High

270498

SLIT1
Slit homolog 1 protein

1

6

High-throughput

0.464

High

270523

MEGF6
Multiple epidermal growth factor-like domains protein 6

1

9

High-throughput

0.464

High

281298

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.464

High

351522

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

12

High-throughput

0.464

High

608854

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

1

High-throughput

0.464

High

654482

FBLN1
Fibulin-1

1

16

High-throughput

0.464

High

915889

CRIP2
Cysteine-rich protein 2

1

5

High-throughput

0.464

High

928258

FBLN2
Fibulin-2

1

16

High-throughput

0.464

High

928259

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

9

High-throughput

0.464

High

928269

DMPK
Myotonin-protein kinase

1

10

High-throughput

0.464

High

928270

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

15

High-throughput

0.464

High

928273

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

14

High-throughput

0.464

High

928275

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.464

High

928278

ECM1
Extracellular matrix protein 1

1

1

High-throughput

0.464

High

928284

PRC2B
Protein PRRC2B

1

19

High-throughput

0.464

High

928288

STXB4
Syntaxin-binding protein 4

1

7

High-throughput

0.464

High

928289

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

1

High-throughput

0.464

High

928301

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

11

High-throughput

0.464

High

928310

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

8

High-throughput

0.464

High

928315

RNF31
E3 ubiquitin-protein ligase RNF31

1

10

High-throughput

0.464

High

928344

CHRD
Chordin

1

7

High-throughput

0.464

High

928351

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

14

High-throughput

0.464

High

928373

RN115
E3 ubiquitin-protein ligase RNF115

1

0

Small-scale

0.460

High

244426

ZN862
Zinc finger protein 862

1

3

High-throughput

0.457

High

270236

MTG16
Protein CBFA2T3

1

4

Small-scale

0.457

High

277086

PROP1
Homeobox protein prophet of Pit-1

1

20

Small-scale

0.457

High

928347

Q9H9J5
cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186

1

1

High-throughput

0.457

High

61166

SSPO
SCO-spondin

1

6

High-throughput

0.439

High

159332

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

7

Small-scale

0.439

High

928251

KR122
Keratin-associated protein 12-2

1

6

High-throughput

0.439

High

928280

KR192
Keratin-associated protein 19-2

1

1

High-throughput

0.439

High

928281

KRA62
Keratin-associated protein 6-2

1

2

High-throughput

0.439

High

928282

KR195
Keratin-associated protein 19-5

1

1

High-throughput

0.439

High

928283

KR151
Keratin-associated protein 15-1

1

1

High-throughput

0.439

High

928287

S2548
Solute carrier family 25 member 48

1

6

High-throughput

0.439

High

928293

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

4

High-throughput

0.439

High

928342

KRA93
Keratin-associated protein 9-3

1

6

High-throughput

0.439

High

67466

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.265

Low

705285

GRN
Progranulin

1

0

High-throughput

0.265

Low

928263

CACB1
Voltage-dependent L-type calcium channel subunit beta-1

1

0

High-throughput

0.265

Low

928336

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.249

Low

928285

Q5ZEY4
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025