HitPredict

Interactor 1: MIER3 (Q7Z3K6)
Mesoderm induction early response protein 3 (Mi-er3)
Gene: MIER3

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	33961781, 35271311, 21258344
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 550 Hs			1 488
+	Hs
		1038488 MIER3_HUMAN (1-550): 1.73e-165: 483: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1231960 MIER2_HUMAN (2-550): 3.12e-128: 387: 36.41		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270415 MTA3_HUMAN (81-484): 5.68e-112: 347: 18.31		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270546 NCOR2_HUMAN (13-524): 1.73e-104: 347: 12.88		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1229946 MIER1_HUMAN (1-511): 1.94e-106: 330: 43.64		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038533 MIER2_HUMAN (2-550): 3.12e-128: 387: 36.41		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1031919 MTA1_HUMAN (102-511): 9.79e-99: 316: 16.63		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936419 MTA1_MOUSE (100-511): 3.05e-97: 312: 16.32		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		296092 MTA2_HUMAN (78-493): 5.53e-94: 302: 16.21		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936428 MTA2_MOUSE (78-493): 1.05e-94: 304: 15.98		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1038676 MTA3_HUMAN (81-484): 5.68e-112: 347: 18.31		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038852 NCOR2_HUMAN (13-524): 1.73e-104: 347: 12.88		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		91458 E7EQY4_HUMAN (81-484): 4.99e-112: 344: 18.31		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038525 MIER1_HUMAN (1-511): 1.94e-106: 330: 43.64		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1031849 MTA1_HUMAN (102-511): 9.79e-99: 316: 16.63		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140302 MTA1_MOUSE (100-511): 3.05e-97: 312: 16.32		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Mm
		140317 MTA2_MOUSE (78-493): 1.05e-94: 304: 15.98		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		296017 MTA2_HUMAN (78-493): 5.53e-94: 302: 16.21		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177416 NCOR2_HUMAN (13-524): 1.73e-104: 347: 12.88		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		1260208 NCOR2_HUMAN (13-524): 1.73e-104: 347: 12.88		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37