Protein: SPP
Signal peptide peptidase (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Minor histocompatibility antigen H13) (Presenilin-like protein 3) (Signal peptide peptidase-like 1)

Gene: SPP, HM13
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q8TCT9

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005791 - rough endoplasmic reticulum
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1350114

RN139
E3 ubiquitin-protein ligase RNF139

2

1

Small-scale

0.612

High

1350132

DERL1
Derlin-1

2

2

Small-scale

0.612

High

1178957

TM266
Transmembrane protein 266

2

0

High-throughput

0.602

High

218520

TGON2
Trans-Golgi network integral membrane protein 2

2

1

High-throughput

0.584

High

905762

CAV2
Caveolin-2

2

1

High-throughput

0.571

High

1350130

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.549

High

354147

CLPT1
Putative lipid scramblase CLPTM1

1

2

High-throughput

0.536

High

698927

CALX
Calnexin

1

3

High-throughput

0.536

High

907041

CCR6
C-C chemokine receptor type 6

1

4

High-throughput

0.536

High

1292846

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.536

High

1322194

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

1

High-throughput

0.536

High

1350122

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

High-throughput

0.536

High

1350127

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

1

High-throughput

0.536

High

1350136

LMA2L
VIP36-like protein

1

3

High-throughput

0.536

High

1350141

GHITM
Growth hormone-inducible transmembrane protein

1

3

High-throughput

0.536

High

1350149

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

3

High-throughput

0.536

High

1350152

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

1

High-throughput

0.536

High

1350158

AGRG1
Adhesion G-protein coupled receptor G1

1

3

High-throughput

0.536

High

608980

XBP1
X-box-binding protein 1

1

1

Small-scale

0.534

High

1350137

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.515

High

690318

STOM
Stomatin

1

0

High-throughput

0.513

High

1067030

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.513

High

1157004

NTRK3
NT-3 growth factor receptor

1

0

High-throughput

0.513

High

1211178

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.513

High

1333676

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.513

High

1350150

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.513

High

1350157

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.513

High

350393

ABHGA
Phosphatidylserine lipase ABHD16A

1

1

Small-scale

0.508

High

48715

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

174007

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.479

High

242366

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

291449

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

374087

RASN
GTPase NRas

1

3

High-throughput

0.479

High

374797

RASH
GTPase HRas

1

2

High-throughput

0.479

High

375755

RASK
GTPase KRas

1

3

High-throughput

0.479

High

404253

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

452343

PDIA1
Protein disulfide-isomerase

1

1

Small-scale

0.479

High

581185

RAC2
Ras-related C3 botulinum toxin substrate 2

1

2

High-throughput

0.479

High

774516

BASI
Basigin

1

1

High-throughput

0.479

High

880623

LMAN1
Protein ERGIC-53

1

3

High-throughput

0.479

High

901961

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

904029

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.479

High

934894

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

962298

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

1015622

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1058540

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

1094295

PDIA2
Protein disulfide-isomerase A2

1

1

Small-scale

0.479

High

1095721

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.479

High

1150600

TRAM1
Translocating chain-associated membrane protein 1

1

1

Small-scale

0.479

High

1324148

PLD6
Mitochondrial cardiolipin hydrolase

1

2

High-throughput

0.479

High

1330323

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

1350113

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

1350118

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

1350125

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.479

High

1350131

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1350138

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

1350140

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

1350144

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1350153

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

1350156

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

179989

BET1
BET1 homolog

1

0

High-throughput

0.458

High

189731

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

246303

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

Small-scale

0.458

High

342975

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

401187

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

414269

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

417615

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418294

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

589228

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

611245

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

634546

LMNB1
Lamin-B1

1

0

High-throughput

0.458

High

642984

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

696011

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

715687

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

820698

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

847616

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

861231

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

887699

PSB2
Proteasome subunit beta type-2

1

0

Small-scale

0.458

High

894922

EMD
Emerin

1

0

High-throughput

0.458

High

900944

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.458

High

951289

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

959218

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1027102

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

1111619

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1145028

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1163383

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1204878

MKS3
Meckelin

1

0

High-throughput

0.458

High

1249044

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1252142

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1294217

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.458

High

1322908

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

1333914

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1350115

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1350120

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1350121

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

1350128

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1350129

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1350135

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1350142

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1350148

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1350151

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1350154

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

170887

CLGN
Calmegin

1

3

High-throughput

0.445

High

779721

MOT8
Monocarboxylate transporter 8

1

1

High-throughput

0.445

High

870273

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.445

High

870390

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

3

High-throughput

0.445

High

1131577

MFS10
Major facilitator superfamily domain-containing protein 10

1

4

High-throughput

0.445

High

1157181

S15A2
Solute carrier family 15 member 2

1

1

High-throughput

0.445

High

1179009

S35G1
Solute carrier family 35 member G1

1

2

High-throughput

0.445

High

1236238

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1316656

S38A6
Solute carrier family 38 member 6

1

1

High-throughput

0.445

High

1350146

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

3

High-throughput

0.445

High

125535

LEG9
Galectin-9

1

1

High-throughput

0.437

High

1238750

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1254764

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1312562

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.437

High

1350124

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1350133

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.437

High

1350155

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1113785

CUL3
Cullin-3

1

0

High-throughput

0.426

High

1175881

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

1209425

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1249745

S49A3
Solute carrier family 49 member A3

1

0

High-throughput

0.426

High

1350134

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1350143

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.426

High

1308909

S22A9
Organic anion transporter 7

1

4

High-throughput

0.407

High

622467

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

1310259

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1350145

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.279

Low

294072

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

519170

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

567452

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.249

Low

630900

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.249

Low

768710

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

965103

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

970818

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1004875

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1118102

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

1178270

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1229580

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1240663

CDC73
Parafibromin

1

0

High-throughput

0.249

Low

1293085

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1350116

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.249

Low

1350117

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.249

Low

1350119

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1350126

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1350139

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.249

Low

1103282

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low

1350123

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.232

Low

1350147

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025