HitPredict

Interactor 1: NT2NA (Q7Z3S9)
Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)
Gene: NOTCH2NLA

Interactor 2: PCSK5 (Q92824)
Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)
Gene: PCSK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 236 Hs			1 1860
+	Hs
		132268 DLL1_HUMAN (43-236): 1.42e-21: 94.7: 25.56		NOTC3_HUMAN (774-1769): 3.87e-55: 215: 11.22
+	Hs
		804372 NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94		NOTC3_HUMAN (774-1769): 3.87e-55: 215: 11.22
+	Hs
		1357251 JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86		NOTC3_HUMAN (774-1769): 3.87e-55: 215: 11.22
+	Hs
		980576 NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84		NOTC3_HUMAN (774-1769): 3.87e-55: 215: 11.22
+	Hs
		132252 DLL1_HUMAN (43-236): 1.42e-21: 94.7: 25.56		NOTC1_HUMAN (1034-1739): 1.2e-38: 161: 11.49
+	Hs
		804163 NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94		NOTC1_HUMAN (1034-1739): 1.2e-38: 161: 11.49
+	Hs
		804379 JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86		NOTC1_HUMAN (1034-1739): 1.2e-38: 161: 11.49
+	Dr
		804160 Q1A5L1_DANRE (8-142): 3.07e-20: 91.2: 39.86		NOTC1_DANRE (1177-1750): 1.27e-27: 125: 12.25
+	Dr
		804161 Q1A5L2_DANRE (106-226): 3.35e-15: 76.2: 26.67		NOTC1_DANRE (1177-1750): 1.27e-27: 125: 12.25
+	Dm
		422713 DL_DROME (12-201): 4.43e-17: 81.6: 33.33		NOTCH_DROME (528-1138): 2.12e-23: 111: 10.54
+	Mm
		966325 DLL1_MOUSE (9-236): 1.7e-22: 97.4: 27.16		NOTC1_MOUSE (1347-1740): 2.45e-17: 91.3: 10.47
+	Dm
		422709 NOTCH_DROME (10-236): 6.06e-15: 75.8: 21.99		NOTCH_DROME (528-1138): 2.12e-23: 111: 10.54
+	Hs
		132255 DLL1_HUMAN (43-236): 1.42e-21: 94.7: 25.56		NOTC2_HUMAN (572-1007): 8.87e-11: 69.7: 11.79
+	Dm
		246736 TENM_DROME (2-124): 1.24e-14: 74.7: 17.71		FUR2_DROME (1471-1769): 4.87e-13: 77: 18.13
+	Hs
		804213 NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94		NOTC2_HUMAN (572-1007): 8.87e-11: 69.7: 11.79
+	Hs
		980578 JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86		NOTC2_HUMAN (572-1007): 8.87e-11: 69.7: 11.79
+	Dm
		422742 NOTCH_DROME (10-236): 6.06e-15: 75.8: 21.99		LAMA_DROME (656-870): 9.08e-09: 62.9: 17.26
+	Dm
		246859 TENM_DROME (2-124): 1.24e-14: 74.7: 17.71		Q8IP51_DROME (967-1163): 9.4e-09: 63.1: 18.09
+	Dm
		246764 TENM_DROME (2-124): 1.24e-14: 74.7: 17.71		LAMA_DROME (656-870): 9.08e-09: 62.9: 17.26