Protein: GUAA
GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase)

Gene: GUAA, GMPS
Organism: Homo sapiens
Interactions: 143
UniProt ID: P49915

Gene Ontology (top 5):
GO:0003921 - GMP synthase activity
GO:0003922 - GMP synthase (glutamine-hydrolyzing) activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006177 - GMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

892485

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

10

5

Small-scale

0.756

High

241098

PRKN
E3 ubiquitin-protein ligase parkin

3

7

High-throughput

0.640

High

623196

RO52
E3 ubiquitin-protein ligase TRIM21

3

2

Small-scale

0.640

High

892444

GUAA
GMP synthase [glutamine-hydrolyzing]

1

7

High-throughput

0.618

High

708934

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

259633

BRD4
Bromodomain-containing protein 4

3

5

High-throughput

0.585

High

413419

P53
Cellular tumor antigen p53

2

2

Small-scale

0.584

High

300122

GLRX3
Glutaredoxin-3

1

2

Small-scale

0.552

High

619614

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.549

High

892457

CUL3
Cullin-3

1

2

High-throughput

0.536

High

892519

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

1

High-throughput

0.536

High

892520

AGO2
Protein argonaute-2

1

2

High-throughput

0.536

High

892529

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

892462

HAPR1
HUWE1-associated protein modifying stress responses 1

2

1

Small-scale

0.533

High

685129

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.513

High

892448

MTPN
Myotrophin

1

0

High-throughput

0.513

High

892468

KIF7
Kinesin-like protein KIF7

1

0

High-throughput

0.513

High

892517

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

187033

PPM1G
Protein phosphatase 1G

1

2

High-throughput

0.489

High

892491

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

143591

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.479

High

170020

AURKA
Aurora kinase A

1

4

High-throughput

0.479

High

315290

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

319529

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

411586

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

487092

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

519848

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

536760

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

731086

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

830349

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

883174

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

887841

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

891381

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

892446

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

892449

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

892451

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

892452

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

892454

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

892455

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.479

High

892459

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

892461

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

892464

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

892469

DCAF6
DDB1- and CUL4-associated factor 6

1

3

High-throughput

0.479

High

892475

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

892482

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.479

High

892484

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

892487

FBX32
F-box only protein 32

1

1

Small-scale

0.479

High

892489

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

892490

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

892494

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

892502

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

892510

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

892514

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

892518

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

892523

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

1

High-throughput

0.479

High

141376

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

720092

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

791186

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

892453

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

892471

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

892472

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

892476

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

892481

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

892500

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

892521

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

892526

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

892503

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

Small-scale

0.457

High

125319

LEG9
Galectin-9

1

1

High-throughput

0.445

High

142307

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.445

High

273836

CNOT3
CCR4-NOT transcription complex subunit 3

1

3

High-throughput

0.445

High

765257

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

892450

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

1

High-throughput

0.445

High

892470

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

892492

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

892506

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

7

High-throughput

0.445

High

892508

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

7

High-throughput

0.445

High

892512

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

892515

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

892524

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

178540

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

1

High-throughput

0.439

High

176041

KDM6B
Lysine-specific demethylase 6B

1

1

Small-scale

0.437

High

371483

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

376762

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.437

High

379949

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

520786

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.437

High

565235

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

588211

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

606434

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.437

High

612941

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

642723

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

694935

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

767705

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

798850

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.437

High

878782

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

892447

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.437

High

892460

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

892466

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

892473

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

892474

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

892477

MGDP1
Magnesium-dependent phosphatase 1

1

1

High-throughput

0.437

High

892478

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.437

High

892483

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.437

High

892486

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.437

High

892496

CIC
Protein capicua homolog

1

2

High-throughput

0.437

High

892505

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

892507

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.437

High

892509

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

892513

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.437

High

892516

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

892522

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.437

High

892525

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

892527

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

326883

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.426

High

369167

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

397915

ANGI
Angiogenin

1

0

High-throughput

0.426

High

892479

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

892499

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.426

High

330079

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

429532

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

689810

CD27
CD27 antigen

1

2

High-throughput

0.407

High

892480

TTC9C
Tetratricopeptide repeat protein 9C

1

4

High-throughput

0.407

High

892504

PCGF6
Polycomb group RING finger protein 6

1

4

High-throughput

0.407

High

892511

ZN331
Zinc finger protein 331

1

1

High-throughput

0.407

High

886638

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

892465

TCAL1
Transcription elongation factor A protein-like 1

2

0

High-throughput

0.313

High

66877

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

389159

FINC
Fibronectin

1

0

High-throughput

0.279

Low

892497

GPX7
Glutathione peroxidase 7

1

0

High-throughput

0.279

Low

892498

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.279

Low

892501

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

105581

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

892445

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.249

Low

892463

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.249

Low

892467

CRY1
Cryptochrome-1

1

0

High-throughput

0.249

Low

892493

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

892495

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.249

Low

599976

ZNF16
Zinc finger protein 16

1

0

Small-scale

0.238

Low

598706

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

892456

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

892458

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

High-throughput

0.232

Low

892488

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

892528

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025